DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif3a

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_006532388.1	Gene:	Kif3a / 16568	MGIID:	107689	Length:	725	Species:	Mus musculus

Alignment Length:	819	Identity:	208/819 - (25%)
Similarity:	345/819 - (42%)	Gaps:	191/819 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRP--------CEPGLTSLWQVKEGRSIQLADSHAEP---YVFDYVFDEGASNQ 57
            ::..:::|.::.||        |.....|:.:::...::...||..||   :.||.||...:...
Mouse    10 ESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQL 74

  Fly    58 EVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQIS-SET 118
            :|::..|:.|:.:.::|.||||||||||.:|||:||.|....|   ||:..:...||..|: :|.
Mouse    75 DVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEG 139

  Fly   119 ERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGN-GIVNVNCKESIVTSEDDLLRQLYMGNK 181
            :..||:||.|:|||||::.|||.| :.|.|::.|..: |:...:....:|.:.||:.|.:.:|:|
Mouse   140 DTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHK 204

  Fly   182 ERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS----- 241
            .|.||.|||||.||||||||.|.||..:.....|..|:...|.||||||||:........
Mouse   205 NRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKE 269

  Fly   242 ------SLMIFRNLVKSLSESVDSKPN--SFRDSKLPRIMLPSLGGNVLTSIICTITPS--FVEE 296
                  ||....|::.:|   ||.|..  .:|:|||.|::..|||||..|.:...|.|:  ..:|
Mouse   270 ATKINLSLSTLGNVISAL---VDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDE 331

  Fly   297 SSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQE---LEG 358
            :.||:.:...||.|:.|.::.: |.:..::||..:.|..||.||.:.:..:.|.:...|   .||
Mouse   332 TISTLRYANRAKNIKNKARINE-DPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEEG 395

  Fly   359 RIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLF 423
            .:..|..|            :|:||.   ::|.|..|:....:.:|.:..||.
Mouse   396 ELGEDGEK------------KKKRRG---SSSSSSSDSTCSVIEKPLDEFLPH------------ 433

  Fly   424 QRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQT 488
                                              |.|::..|  |..|:
Mouse   434 ----------------------------------QAGKKKVS--PDKMV---------------- 446

  Fly   489 EISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSSI 553
            |:.|             |.:|:.|.|:..::..|.|..||          :|:.::.|::||.:.
Mouse   447 EMQA-------------KIDEERKALETKLDMEEEERNKA----------RAELERREKDLLKAQ 488

  Fly   554 SEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLDS 618
            .|..    ||.:.|..|.:.|:....:                :..|..|.|:||. .|...|:.
Mouse   489 QEHQ----SLLEKLSALEKKVIVGGVD----------------LLAKAEEQEKLLE-ESNMELEE 532

  Fly   619 VACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKY---- 679
            ...:.:|||.|:.....:...:...::....|...||...|::...:..|..:...||:::
Mouse   533 RRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREI 597

  Fly   680 ----NNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDE---QCQQLQDENSKLQA 737
                .|::.  .|::|.:..:.:| |.|.|.|.::.:.|.|......|   :|......|.:.|.
Mouse   598 EGLLENIRQ--LSRELRLQMLIID-NFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQT 659

  Fly   738 EIGTLKER---------------VEEIHSELLEVPNPDT 761
            .:...|||               .|.:...|:::..|.|
Mouse   660 PVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRT 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	121/339 (36%)
		Motor_domain	8..310	CDD:277568	119/333 (36%)
		SMC_prok_B	<471..1270	CDD:274008	60/317 (19%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	119/334 (36%)
		SMC_N	<340..717	CDD:308206	91/486 (19%)
		SMC_prok_B	<449..>615	CDD:274008	40/211 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910