DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif5b

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_476550.1	Gene:	Kif5b / 117550	RGDID:	621559	Length:	963	Species:	Rattus norvegicus

Alignment Length:	1153	Identity:	289/1153 - (25%)
Similarity:	490/1153 - (42%)	Gaps:	294/1153 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIQVCIKVRPCEPGLTSLWQVKEG----------RSIQLADSHAEPYVFDYVFDEGASNQEVFDR 62
            :|:|..:.||....     :|..|          .::.:|   ::||.||.||....|.::|::.
  Rat     8 NIKVMCRFRPLNES-----EVNRGDKYVAKFQGEDTVMIA---SKPYAFDRVFQSSTSQEQVYND 64

  Fly    63 MAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-DFL 123
            .||.||...::|.|||||||||||||||:||.|   |.:..|::....::||..|.|..|. :|.
  Rat    65 CAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFH 129

  Fly   124 LRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGE 187
            ::|.|.|||.:||.|||:....:|.:||..|.:..| .|.|..|.|.|:::..:..|...|.|..
  Rat   130 IKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAV 194

  Fly   188 TNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPA-------DHA----S 241
            |||||.|||||:||.|.:   |.:::..:......|.||||||||:|...       |.|    .
  Rat   195 TNMNEHSSRSHSIFLINV---KQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINK 256

  Fly   242 SLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFVEES--SSTISFG 304
            ||....|::.:|:|.....|  :||||:.||:..|||||..|:|:...:||...||  .||:.||
  Rat   257 SLSALGNVISALAEGSTYVP--YRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFG 319

  Fly   305 TCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNES-QLVLQELEGRIKRDMLKIV 368
            ..||.|  |..|| ::.|.|        ....|.|..|:|.||:: :..:|.||..:.|  .:..
  Rat   320 QRAKTI--KNTVC-VNVELT--------AEQWKKKYEKEKEKNKTLRNTIQWLENELNR--WRNG 371

  Fly   369 SSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLFQRRGIAPKAK 433
            .:..:|:...:::......||     |..|....:...:.:......|:.     :||....:..
  Rat   372 ETVPIDEQFDKEKANLEAFTA-----DKDVAITNDKPAAAIGMAGSFTDA-----ERRKCEEEIA 426

  Fly   434 GICKTLKEKRLQTDNMDTMPGRAK--QLGRETASRIPSVMMSKKYQESVPNCDAPQTEISALTAS 496
            .:.|.|.:|..:.:....:..:.|  .|.:|      .::.|.:..:     |..|.|::.|.|.
  Rat   427 KLYKQLDDKDEEINQQSQLVEKLKTQMLDQE------ELLASTRRDQ-----DNMQAELNRLQAE 480

  Fly   497 NQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLS-SISEKDSTI 560
            |..:|       |:||.:.:.:|.|      |||..:  ::.:.:.|..|.|||| .:::|.:|:
  Rat   481 NDASK-------EEVKEVLQALEEL------AVNYDQ--KSQEVEDKTKEYELLSDELNQKSATL 530

  Fly   561 VSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLDSV-----A 620
            .|:...|::|..  :.|.::.:...|...|             |:.|..:..|.|.:.|     .
  Rat   531 ASIDAELQKLKE--MTNHQKKRAAEMMASL-------------LKDLAEIGIAVGNNDVKQPEGT 580

  Fly   621 CQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHK 685
            ...|:   |....|:.:..|.|       ||......||:|.   ||         :..:|.|.:
  Rat   581 GMIDE---EFTVARLYISKMKS-------EVKTMVKRCKQLE---ST---------QTESNKKME 623

  Fly   686 WSSQKLAIDTMQVDYNTIQQK----YLQ-LQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLKER 745
            .:.::||...:::..:..:.|    ||| ::.:.|.||    |....|.:|..:|:|:
  Rat   624 ENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLE----ESVDSLGEELVQLRAQ------- 677

  Fly   746 VEEIHSELLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTI-QECDALR 809
             |::|              :||      |:.|:|:|            .:||:...: |:..:.|
  Rat   678 -EKVH--------------EME------KEHLNKVQ------------TANEVKQAVEQQIQSHR 709

  Fly   810 EEHKQRTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFIYNH 874
            |.|:::     :.|::..      .:.:.:|.|||
  Rat   710 ETHQKQ-----ISSLRDE------VEAKEKLITDL------------------------------ 733

  Fly   875 AEQDQSVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQN-LVKEEDRMRD 938
              |||   :.|:.||..:                    |:.:..::..::||:: .:.|...|:|
  Rat   734 --QDQ---NQKMVLEQER--------------------LRVEHERLKAVDQEKSRKLHELTVMQD 773

  Fly   939 IIFQLKQEVDGKKNLIEEEKEVINNLRAQITSLNQIETIKNQNAKTKI-LCEELQTKDTVQTANK 1002
            ...|.:|::.|.:..:.:|.:.::|||....          |:..|:: ...|:.:.||..:|
  Rat   774 RREQARQDLKGLEETVAKELQTLHNLRKLFV----------QDLATRVKKSAEVDSDDTGGSA-- 826

  Fly  1003 QESQEVLTLKTSLAHLKSKV------------CELQKKLEK--QSEDEKISELQSDIGEISECCL 1053
            .:.|::..|:.:|..| :||            ||| .||||  ::..|::..|:|.:.|..|..
  Rat   827 AQKQKISFLENNLEQL-TKVHKQLVRDNADLRCEL-PKLEKRLRATAERVKALESALKEAKENA- 888

  Fly  1054 SMELKLADIVNWQAEELRPLDQLQESGVELQHHSTTAEESLNVEKPIQ 1101
            |.:.|     .:|.|..|..:.::...:..:.||.      .:.|||:
  Rat   889 SRDRK-----RYQQEVDRIKEAVRSKNMARRGHSA------QIAKPIR 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	126/335 (38%)
		Motor_domain	8..310	CDD:277568	124/329 (38%)
		SMC_prok_B	<471..1270	CDD:274008	135/659 (20%)
		Mplasa_alph_rch	924..1647	CDD:275316	46/194 (24%)
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif5b	NP_476550.1	KISc_KHC_KIF5	6..325	CDD:276820	124/329 (38%)
		KISc	8..332	CDD:214526	128/339 (38%)
		DUF4337	<462..>538	CDD:290935	25/95 (26%)
		TACC	467..662	CDD:282818	57/255 (22%)
		TMPIT	598..>686	CDD:285135	28/138 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..963		5/24 (21%)
		Globular. /evidence=ECO:0000255	915..963		5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910