DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and KIF3A

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_001287720.1	Gene:	KIF3A / 11127	HGNCID:	6319	Length:	726	Species:	Homo sapiens

Alignment Length:	889	Identity:	218/889 - (24%)
Similarity:	365/889 - (41%)	Gaps:	218/889 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRP--------CEPGLTSLWQVKEGRSIQLADSHAEP---YVFDYVFDEGASNQ 57
            ::..:::|.::.||        |.....|:.:::...::...||..||   :.||.||...:...
Human    10 ESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQL 74

  Fly    58 EVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQIS-SET 118
            :|::..|:.|:.:.::|.||||||||||.:|||:||.|....|   |::..:...||..|: :|.
Human    75 DVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAEG 139

  Fly   119 ERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGN-GIVNVNCKESIVTSEDDLLRQLYMGNK 181
            :..||:||.|:|||||::.|||.| :.|.|::.|..: |:...:....:|.:.||:.|.:.:|:|
Human   140 DTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHK 204

  Fly   182 ERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS----- 241
            .|.||.|||||.||||||||.|.||..:.....|..|:...|.||||||||:........
Human   205 NRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKE 269

  Fly   242 ------SLMIFRNLVKSLSESVDSKPN--SFRDSKLPRIMLPSLGGNVLTSIICTITPS--FVEE 296
                  ||....|::.:|   ||.|..  .:|:|||.|::..|||||..|.:...|.|:  ..:|
Human   270 ATKINLSLSTLGNVISAL---VDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDE 331

  Fly   297 SSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQE----LE 357
            :.||:.:...||.|:.|.::.: |.:..::||..:.|..||.||.:.:..:.|.:...|    .|
Human   332 TISTLRYANRAKNIKNKARINE-DPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEE 395

  Fly   358 GRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPL 422
            |.:..|..|            :|:||.   ::|.|..|:....:.:|.:..||
Human   396 GEVGEDGEK------------RKKRRG---SSSSSSSDSTCSVIEKPLDKFLP------------ 433

  Fly   423 FQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQ 487
                                              .|.|::..|  |..|:
Human   434 ----------------------------------NQAGKKKVS--PDKMI--------------- 447

  Fly   488 TEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSS 552
             |:.|             |.:|:.|.|:..::..|.|..||          :|:.::.|::||.:
Human   448 -EMQA-------------KIDEERKALETKLDMEEEERNKA----------RAELEKREKDLLKA 488

  Fly   553 ISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLD 617
            ..|..    ||.:.|..|.:.|:....:                :..|..|.|:||. .|...|:
Human   489 QQEHQ----SLLEKLSALEKKVIVGGVD----------------LLAKAEEQEKLLE-ESNMELE 532

  Fly   618 SVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKY--- 679
            ....:.:|||.|:.....:...:...::....|...||...|::...:..|..:...||:::
Human   533 ERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQRE 597

  Fly   680 -----NNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEI 739
                 .|::.  .|::|.:..:.:| |.|.:.|.::.:.|.|..       :.:.:...|..|..
Human   598 IEGLLENIRQ--LSRELRLQMLIID-NFIPRDYQEMIENYVHWN-------EDIGEWQLKCVAYT 652

  Fly   740 GTLKERVEEIHSELLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNY--ECLSNELMSTI 802
            |....:         :.|.||             ||.....:.:...:.|.|  |.|...||..
Human   653 GNNMRK---------QTPVPD-------------KKEKDPFEVDLSHVYLAYTEESLRQSLMKL- 694

  Fly   803 QECDALREEHKQRTTNSDLESMKSSGVGTECSDPENELDTDLLQ 846
                       :|...|..::...:|.....:.||..:|: |||
Human   695 -----------ERPRTSKGKARPKTGRRKRSAKPETVIDS-LLQ 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	120/339 (35%)
		Motor_domain	8..310	CDD:277568	118/333 (35%)
		SMC_prok_B	<471..1270	CDD:274008	71/386 (18%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	118/334 (35%)
KIF3A	NP_001287720.1	SMC_prok_B	<450..>616	CDD:274008	40/211 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910