DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif22

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_006507264.1	Gene:	Kif22 / 110033	MGIID:	109233	Length:	690	Species:	Mus musculus

Alignment Length:	682	Identity:	157/682 - (23%)
Similarity:	282/682 - (41%)	Gaps:	159/682 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRPCEPGLTSLWQVKEGRSIQLADS------------HAEPYVFDYVFDEGASNQEVFD 61
            ::|.:::||...|.|   :.||...::..||            ....|.||..:.|.::.|||:.
Mouse    39 VRVAVRLRPFMDGET---EAKELPCVRAIDSCSLEVANWKKYQETLKYQFDAFYGEKSTQQEVYV 100

  Fly    62 RMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETER----DF 122
            ...:.|:...::|.|.::.|||.|.:|||:||:|..:.|||:..|..::.|....|:..    |.
Mouse   101 GSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLAREESAEGRPWDV 165

  Fly   123 LLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNG-IVNVNCKESIVTSEDDLLRQLYMGNKERVVG 186
            .:.:.|:|||.||:.|||:..:.||.|.|...| |:.....:..:||..|..:.....::.|.||
Mouse   166 SVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFSDFEQHFLPASRNRAVG 230

  Fly   187 ETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQ-----------VDPADHA 240
            .|.:|:|||||||:..:.::.|  :.......::..|.|:||||||.           .:.....
Mouse   231 ATRLNQRSSRSHAVLLVKVDQR--ERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAIN 293

  Fly   241 SSLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPS--FVEESSSTISF 303
            :||.:...:|.:|::.:...|  :|||||.|::..||||:..:.:|..|.|.  |.:::.|.::|
Mouse   294 TSLFVLGKVVDALNQGLPRIP--YRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNF 356

  Fly   304 GTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQL----------------- 351
            ...:|::..:|    ..:|:....      ::...||::|::...|:.
Mouse   357 TARSKEVINRP----FTNESLQPH------ALAPVKLSQKELLGPSEAKKAKGPEEESTGSPEST 411

  Fly   352 -----------VLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPE 405
                       :||:|..         :..|.|::....:|    .|.:.||:| .|:|..|:.|
Mouse   412 AAPASASQKLSLLQKLSN---------MDPAMLENLLSMER----LLGSQGSQG-TPLLNTPKRE 462

  Fly   406 ESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTD--NMDTMPGRAKQLGRETASRIP 468
            ...|                          .||::||.|:.:  .|......||.|.:|..
Mouse   463 RMVL--------------------------MKTVEEKNLEIERLKMKQKELEAKVLAQEAP---- 497

  Fly   469 SVMMSKKYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGE 533
                ..:.:|:.|....|....|...|  :..|:.:....:::::.:|:..::::
Mouse   498 ----DPREKENTPTILQPPASYSGTVA--KPLKKAVVMPLQRIQKQRESSNQIQL---------- 546

  Fly   534 QFETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSR------DVLRNSKEDQMRSMCPELES 592
               ..|...:::|....|...|||.....:|.|.|.|:.      |:|......::||:
Mouse   547 ---LKKGPKRKLEPSPESEAVEKDEDYWEVQISPELLAHGRKKLLDLLNEGSARELRSL------ 602

  Fly   593 SCERICNKCLEL-----ERLLPLASASGLDSV 619
              :||..|..:|     |...|.:....|:.|
Mouse   603 --QRIGQKKAQLIVGWRELHGPFSEVEDLEQV 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	98/336 (29%)
		Motor_domain	8..310	CDD:277568	97/330 (29%)
		SMC_prok_B	<471..1270	CDD:274008	29/160 (18%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif22	XP_006507264.1	KISc_KID_like	38..361	CDD:276827	96/328 (29%)
Kif22	XP_006507264.1	ComEA	<591..641	CDD:393460	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900