Protein Alignment cana and CENPE

DIOPT Version :10

• Sequence 1: NP_001027247.1
• Gene: cana / 3771934
• FlyBaseID: FBgn0040233
• Length: 1931
• Species: Drosophila melanogaster
• Sequence 2: NP_001804.2
• Gene: CENPE / 1062
• HGNCID: 1856
• Length: 2701
• Species: Homo sapiens
• Alignment Length: 2219
• Identity: 537/2219 - (24%)
• Similarity: 961/2219 - (43%)
• Gaps: 514/2219 - (23%)

  Fly     8 SIQVCIKVRPCEPGLTSL-------WQVKEGRSIQLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65
            ::.||::|||......||       |:.......|:..|  :.:.||.||....:.:.|::.:|.
Human     6 AVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS--KSFNFDRVFHGNETTKNVYEEIAA 68

  Fly    66 HIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIE 130
            .|:.:.:||.||||||||||:|||||||||.|.:.||:..|..:|||:|....:|:|||||.|:|
Human    69 PIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYME 133

  Fly   131 IYNEKIYDLL--NKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGETNMNE 192
            ||||.|.|||  .:|.:.|.|.|..|..|.| :..|.:|.:.:..|:.:..|.|.|..|||.||:
Human   134 IYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQ 198

  Fly   193 RSSRSHAIFRIIIESRKSDHSDN--DTVKQSVLSLVDLAGSEQVDPADHAS-----------SLM 244
            ||||||.|||:|:|||:.....|  .:||.|.|:||||||||:......|.           ||.
Human   199 RSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLF 263

  Fly   245 IFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFVEESSSTISFGTCAKK 309
            |...::|.||:.......::|||||.||:..|||||..|.|||||||...:|:.:.:.|.:.||.
Human   264 ILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKY 328

  Fly   310 IRCKPQVCKIDSETTMM-----------RQLD------RGISMLKDKLAK--------KKIKNE- 348
            ::..|.|.::.::..::           :||:      |..:|.||:||:        :|::||
Human   329 MKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEK 393

  Fly   349 -----------SQLVL-QELEGRIKRDML-------KIVSSASLDDYRLQKRRRTWTLTAS---- 390
                       |.|.| |||:.:.||.:.       |:.:|...|.:.:.....|.|...|
Human   394 IENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLL 458

  Fly   391 -------GSEGDAPVLALPEPEESRLPRPSKL---TNLPKPLFQRRG-----------IAPKAKG 434
                   .||.|.....|....|......:||   .|:...|...|.           :..:.:.
Human   459 REIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEE 523

  Fly   435 ICKTLKEKRLQTDNMDTMPGRAK-----QLGRETASRIPSVMMSKKYQESVPNCDAPQTEISALT 494
            :...||||. ..|..:.:..:.|     ||..|.::....|..::.|.:.:.|      |:|:..
Human   524 MELKLKEKN-DLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLEN------ELSSKV 581

  Fly   495 ASNQVAKETIEKYEEQVKRLKETIERLEMENGKA------------------------------- 528
                   |.:.:.|:|:|:|:|.|:..::||.|.
Human   582 -------ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639

  Fly   529 ---------VNLGEQFETHKAKSKQMEEEL---LSSISEKDSTIVSLQQSLE------------- 568
                     :.|.|:.:......||||.::   .|.:..|....|.|::.|:
Human   640 ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLI 704

  Fly   569 --ELSRDVLRNSK-EDQMRSMCPELESSCERICNKCLELERLLPLASASGLDSVACQFDQLRSEI 630
              ::.:|:|.|.: |.::..:..||....|.  |:.|..|.:|    .|.|.|:..:.::||.||
Human   705 DGKVPKDLLCNLELEGKITDLQKELNKEVEE--NEALREEVIL----LSELKSLPSEVERLRKEI 763

  Fly   631 AATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHKWSSQKLAIDT 695
            .....:|..:.|.......||..|.:..:.|.|:|....||....|..|.:...::.:.|    |
Human   764 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK----T 824

  Fly   696 MQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLKE----RVEEIHSELLEV 756
            :.:|:   :|||..:.:|..    |.:::...|..|..|..:.:|.||.    :.:|:..:..||
Human   825 LHMDF---EQKYKMVLEENE----RMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV 882

  Fly   757 PNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALREEHKQRTTNSDL 821
               .....:||...::|:.|.|.||    .::.....::.:|..|::|...|.:|      ..||
Human   883 ---QERLNEMEQLKEQLENRDSTLQ----TVEREKTLITEKLQQTLEEVKTLTQE------KDDL 934

  Fly   822 ESMKSS------GVGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFIYNHAEQDQS 880
            :.::.|      .:.::..|..| ::.|..:|.....:|::|                |.|...:
Human   935 KQLQESLQIERDQLKSDIHDTVN-MNIDTQEQLRNALESLKQ----------------HQETINT 982

  Fly   881 VPSLKLCLEPAKYL---EGDGKQHDASDSVFL----KGFLKCQRFQIVKINQEQNLVKEEDRMRD 938
            :.| |:..|.::.|   |..|:..|......:    |..|:.:..|.:..:.:.|.:.|:.|.
Human   983 LKS-KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK-- 1044

  Fly   939 IIFQLKQEVDGKKNLIE----EEKEVINNLRAQITSLNQIETIKNQNAKTKILCEELQTKDTVQT 999
             ||.|.||.:..:.::|    |::::..:|:..|..     ||:||. :.::|.:||:.:..:..
Human  1045 -IFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM-----TIENQE-ELRLLGDELKKQQEIVA 1102

  Fly  1000 ANKQESQEVLTLKTSLAHLKSKVCELQKKLEKQSEDEKISELQSDIGEISECCLSMELKLADIVN 1064
               ||....:..:..|:....::.|:::||:::|  :::.|.|..:..:.|....|:.|:.:|.|
Human  1103 ---QEKNHAIKKEGELSRTCDRLAEVEEKLKEKS--QQLQEKQQQLLNVQEEMSEMQKKINEIEN 1162

  Fly  1065 WQAEELRPLDQLQESGVELQHHSTTAEESLNVEKPIQEQTERTLTTEYERRI-EQLEESLQRAQE 1128
            .:       ::|:...:.|:|..|   |.|.:.:.:.|..|...:...||:: ::|::|.:..::
Human  1163 LK-------NELKNKELTLEHMET---ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERD 1217

  Fly  1129 ELSILEKRKTDENKSLQLEYMAKIETSENENRSKFRAYCLDLKETQKRYEEQLQQTNEKLASVT- 1192
            .|.               .|:.:||.:..:.:.:.:...:.|||.|:..:|..:..:||.|.:.
Human  1218 HLR---------------GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN 1267

  Fly  1193 --------TQCQVHLDVIKRSLQ-----EKITQAEKERNEL------------AVRHKAELEKIR 1232
                    |:.|..:.|:....:     :::::.::..|||            ....:.|:|::|
Human  1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332

  Fly  1233 ETLKEKESSYKEKLRQAEEERD--KEISR-LEV--------MRNTIAELHKTNSDREVEL----- 1281
              |.||....:|:::...:|||  |.|.. |||        :|.|:|::.::.|.:|..|
Human  1333 --LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395

  Fly  1282 --EGVK----MEKCQLKKLYDKSML--ELEQLQCTAD-QKSSDLLPGSSNENIDDLQKKCDQYVQ 1337
              |..|    ||:.:.|   |.::|  |:|.|..:.. |:|.|.:...:.|. ||||:     :|
Human  1396 DNETTKIVSEMEQFKPK---DSALLRIEIEMLGLSKRLQESHDEMKSVAKEK-DDLQR-----LQ 1451

  Fly  1338 DLELLRGEKAELLSEIQKINGQHSNTIKKLEEIEAEMITLTTQKELE--RCEIAEKLETFKSKEA 1400
              |:|:.|..:|...|::|..:|                |.|::||:  .|.:.|:.||......
Human  1452 --EVLQSESDQLKENIKEIVAKH----------------LETEEELKVAHCCLKEQEETINELRV 1498

  Fly  1401 DIKE---ALHCAQLRLHAYDKLVCEYERLKGCLSDSNKLSENLQKKVERLHAEQLALQEGISGRD 1462
            ::.|   .:...|.:|.|                    :::.||.|::.::.::         ..
Human  1499 NLSEKETEISTIQKQLEA--------------------INDKLQNKIQEIYEKE---------EQ 1534

  Fly  1463 SEIKQLRSELKDAIDENKTVREAKVGLENSLKAVQENMSAQEGQFKQKIADIKGSVDELQIKLKS 1527
            ..|||: ||:::.::|.|..:|.:...:::|::::..|.....:.::       |.:|:||.:|.
Human  1535 FNIKQI-SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE-------SQEEIQIMIKE 1591

  Fly  1528 LQEV----------RDHLESRNEELKRKLKDAQELQNMVDKERKLNSS---------LREDFDKL 1573
            .:|:          ||.|:...:|:..|:|::||.:....|...:|.:         |:|.|
Human  1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQF--- 1653

  Fly  1574 EQTKLDLE----EQLRAKKVEIDRRSKELGEVTKDCENIRSDLEAQTNDFLKERETLNLTISDLR 1634
            |..||:||    |.:|..:: :....:|:..|||:.:::||           ..|||.:....|:
Human  1654 ETQKLNLENIETENIRLTQI-LHENLEEMRSVTKERDDLRS-----------VEETLKVERDQLK 1706

  Fly  1635 LHNEQLLETSKNYLSDITAANNLNLEMKKNLHDLTKECKSLRSDLQSKEEYFQTQKQLLDETISN 1699
               |.|.||....|........:::.:|::...:.|    ||..:..|.......::.|:.:...
Human  1707 ---ENLRETITRDLEKQEELKIVHMHLKEHQETIDK----LRGIVSEKTNEISNMQKDLEHSNDA 1764

  Fly  1700 LKEENRKMEEKLSSGNKALKEDCE---KLRSTLESKELILQQNKQELEERLTVINEKNGKNALLD 1761
            ||.::.|::|:|...:..|||..|   |||..:..|...|...:::||.....:.||       .
Human  1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEK-------I 1822

  Fly  1762 AQLKSNETAFTSLR----------------KAWIK-QSLAIEAANKRSLEMEQKVDKRTREYEEL 1809
            .:||:||....:|:                |..|| |||.:......:|.:.||:.:   ..||:
Human  1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE---NLEEM 1884

  Fly  1810 RSTLKTREINFRSEKERM----DGTISSLLEDK-RNLE--EKLCTVTELLAKLKRELPALHTQKV 1867
            :|.:|.|: |.|..:|.:    |....||.|.| |:||  ::|.| ..:|:|..:|......:|:
Human  1885 KSVMKERD-NLRRVEETLKLERDQLKESLQETKARDLEIQQELKT-ARMLSKEHKETVDKLREKI 1947

  Fly  1868 NGGDVSIELNSSNGSPTPAAVPATKKPLDCNSAECVPKKSSSLETAE-----------RKNRRMT 1921
            :  :.:|:::.            .:|.|| .|.:.:.||...|:..|           ..::::.
Human  1948 S--EKTIQISD------------IQKDLD-KSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN 1997

  Fly  1922 AYDENRKQF 1930
            ..::.:|||
Human  1998 EMEQLKKQF 2006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	Motor_domain	8..310	CDD:473979	137/324 (42%)
		CCDC158	<505..>729	CDD:464943	58/282 (21%)
		SMC_prok_B	622..1285	CDD:274008	151/728 (21%)
		SMC_prok_B	1110..1875	CDD:274008	195/871 (22%)
CENPE	NP_001804.2	KISc_CENP_E	6..329	CDD:276825	137/324 (42%)
		SMC_prok_B	345..1131	CDD:274008	175/859 (20%)
		SMC_prok_B	828..1715	CDD:274008	223/1047 (21%)
		SMC_prok_B	1332..2129	CDD:274008	183/790 (23%)
		SMC_N	1730..>2573	CDD:481474	72/308 (23%)
		Kinetochore-binding domain	2126..2476
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2355..2376
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2508..2533
		Globular autoinhibitory domain. /evidence=ECO:0000250	2510..2698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2588..2701