Protein Alignment cana and cenpe

DIOPT Version :9

• Sequence 1: NP_001027247.1
• Gene: cana / 3771934
• FlyBaseID: FBgn0040233
• Length: 1931
• Species: Drosophila melanogaster
• Sequence 2: XP_004911147.2
• Gene: cenpe / 100126678
• XenbaseID: XB-GENE-952286
• Length: 3358
• Species: Xenopus tropicalis
• Alignment Length: 2702
• Identity: 630/2702 - (23%)
• Similarity: 1028/2702 - (38%)
• Gaps: 928/2702 - (34%)

  Fly     1 MSTKNASSIQVCIKVRPC---EPG--LTSLWQVKEG-RSIQLADSHAEPYVFDYVFDEGASNQEV 59
            ||.::|  ::||::|||.   |.|  .|.||  |.| .:|...|. .:.:.||.||:...|..:|
 Frog     1 MSEEDA--VKVCVRVRPLIQREQGDQSTLLW--KAGSNTISQVDG-TKSFSFDRVFNSHESTSQV 60

  Fly    60 FDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLL 124
            :..:|..|:.:.:||.||||||||||||||||||||...:.|::..|.:|:|:.|.....|:|||
 Frog    61 YQEIAVPIIQSALQGYNGTIFAYGQTSSGKTYTMMGTPNSLGIIPQAIQEVFKIIQEIPNREFLL 125

  Fly   125 RVGYIEIYNEKIYDLL--NKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVG 186
            ||.|:|||||.:.|||  ::|.:.|:|.|..|..|.| :..|.:|...|.:::.:..|.|.|..|
 Frog   126 RVSYMEIYNETVKDLLCDDRKKKPLEIREDINRNVYVADLTEELVMVPDHVIQWIKKGEKNRHYG 190

  Fly   187 ETNMNERSSRSHAIFRIIIESRKSDHSDND-----TVKQSVLSLVDLAGSEQV-----------D 235
            ||.||:.|||||.|||:|:|||..:.|.|.     .|..|.|:||||||||:.           :
 Frog   191 ETKMNDHSSRSHTIFRMIVESRDRNDSANSENCDGAVMVSHLNLVDLAGSERASQTGAEGVRLKE 255

  Fly   236 PADHASSLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFVEESSST 300
            ..:...||.|...::|.||:.......::|||||.||:..|||||..|.|||||||...:|:.||
 Frog   256 GCNINRSLFILGQVIKKLSDGQAGGFINYRDSKLTRILQNSLGGNAKTVIICTITPVSFDETLST 320

  Fly   301 ISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKL----------AKKKIKNE-SQLVLQ 354
            :.|.:.||.:|..|.|.::..:..::::..:.|..||.:|          |:...|.| |||:.:
 Frog   321 LQFASTAKHMRNTPHVNEVLDDEALLKRYRKEILELKKQLEDLETSSEIKAQAMAKEEHSQLLAE 385

  Fly   355 ------ELEGRIKRDMLKIVSSA--SLDDYRLQKRRR-TW-------TLTASG-SEGDAPVLALP 402
                  |.|.||......:|:|:  |..|.|::::|| ||       :|..|. |:.|.|
 Frog   386 IKLLQKEREDRIWHLTNIVVASSQESQQDQRVKRKRRVTWAPGKIHSSLHGSSVSDFDMP----- 445

  Fly   403 EPEESRLP----RPSKLTNLPK-------------------PLFQRRGI---------------- 428
                ||||    :.:|.::||.                   .:....||
 Frog   446 ----SRLPGNFSKKAKFSDLPAFPEIDDSVCTEFSDFDDPISMIDNNGIDAEWNFASKVTRREKA 506

  Fly   429 ---------------------APKAKGICK--------TLKEKRLQ-----------------TD 447
                                 :.|....|:        |..:::||                 |:
 Frog   507 SLHQSMMDFEGRISDSVQFHDSSKEMAECRRASFEKEITSLQQQLQSKEEEKRQLVQSFELKITE 571

  Fly   448 NMDTMPGRAKQLGRETASRIPSV------------------------------------------ 470
            ....:..|||.|...|..|..|:
 Frog   572 LEGQLRDRAKNLEMVTDLREHSINAEVQVDFEKEVLRKEMSVLGDSGYNASSSGLQDSSIDRKRL 636

  Fly   471 --------------------------MMSKK------------YQESVPNCDA------------ 485
                                      .:|||            :.|||..|:|
 Frog   637 SSSHDECIEHKKMLEQKIADLEEFIKNLSKKSENDAQKSHEQDFMESVQLCEALIAEKANALEEL 701

  Fly   486 ----------------PQTEISALTAS---NQ-------VAKETIEKYEEQ----VKRLKETIER 520
                            .:.||:.|..|   ||       :.|||.:::|.|    :..||:.:|.
 Frog   702 ALMRDQFDGVILENETLKREIADLERSLKENQETNEFEILEKETQKEHEAQLIHEIGNLKKLVEN 766

  Fly   521 LEMENGKAVNLGEQFETHKAKSKQMEEELLS-----------------SISEKDS-----TIVSL 563
            .||.|   .:|.|..:|.....|:.|.:|..                 |:|..||     .:..|
 Frog   767 AEMYN---QSLEEDLDTKTKLLKEQEMQLAELRKHTDNLQKKVRNFDLSVSMGDSERLCEEVFQL 828

  Fly   564 QQSL---EELSRDVLR-----------------------NSKEDQ------------------MR 584
            :|||   |.::||..:                       |.||.:                  ..
 Frog   829 KQSLCDAEAVTRDAQKECAFLRSENLELKEKMEDTSAWYNQKEKEASLFEKQLETEKANYKKMQT 893

  Fly   585 SMCPELESSCERI----------------CNKCLE---------LERLLPLASA--------SGL 616
            .:..||:|:...|                |...||         ||:.|...:|        |..
 Frog   894 DLQKELQSAFNEINYLNGLMAGKVPKDLLCRVELEKKVSEYSKQLEKALEEKNALENEVTCLSEY 958

  Fly   617 DSVACQFDQLRSEI-----------------AATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQ 664
            .|:..:.|.|:.:|                 ::||.|.|.:|...|....|::.|.|..:...:|
 Frog   959 KSLPKEVDFLKDQISKASDEIMLLKHEGELSSSTRSKQEVILQEQSGQIVELTDKVTQTQSKVQQ 1023

  Fly   665 -------ISTAHDDFGQLQEKY---------------------NNLKH-------KWSSQKLAID 694
                   :...|||   |.||:                     .|||.       |.::.|..::
 Frog  1024 AEEQYLEMKKMHDD---LYEKFICTTEETTKNKREAEDLLREIENLKGTMETLEVKLAATKHELE 1085

  Fly   695 TMQVDYNTIQQK---YLQ----------LQDEYRHLELRSDEQCQQ-LQ-DENSK---------- 734
            ..|:|...:..|   .||          |.|....|....:|:.|. :| ||..|
 Frog  1086 ECQMDKEQLLNKKNFLLQAMQAAFSVASLSDSSPSLSTLVEEKSQDPIQTDEYHKLISLAKERTS 1150

  Fly   735 ----LQAEIGTLKERVEEIHSELLEVPNPDTHPEDMELQNQELKKR-------LSKLQWEFDEIQ 788
                |:.|..:|||:|.::.||:..:........|::.:.|:|:.:       :.:||.:..|.|
 Frog  1151 IMVCLETERNSLKEQVIDLTSEVQSLQAQGIGKSDLQKEKQDLEDKWVKLVSEMEQLQAQLTESQ 1215

  Fly   789 LNYECLSNELMSTIQECDALREEHKQRT-----TNSDLESMKSSGVGTECSDPENELDTDLLQQF 848
            |:.|.:..|.:...::..:|:||.|..|     ..::||.:|:     |....:.:|..::.|..
 Frog  1216 LSLEKMQLENLEVTEKQQSLQEEMKNITKERNDLQTNLEDLKA-----ERDSLKQDLSENIEQSI 1275

  Fly   849 ----------------TKLSKSIQQIELTDYSGG------------RRLFIYN---------HAE 876
                            .:|..|::| :|.|..||            .:|.::.         ..|
 Frog  1276 ETQDELRAAQEELGGQKQLVDSLRQ-QLVDCVGGVLSPNHDSAGEQEKLSLFKENLQECEMLRGE 1339

  Fly   877 QDQ-------SVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEED 934
            :|:       .|..|:|..|..|.:||:.          ::|   .|:..|:: |:.....:|.:
 Frog  1340 RDELQTSCKALVSELELLREHVKSVEGEN----------IEG---AQKLHILE-NEILGTSEERE 1390

  Fly   935 RMRDIIFQLKQEVDGKKNLIEEEKEVINNLRAQITSLNQIETIKNQNAKTKILCEELQTKDTVQT 999
            .::.::..:|:|.:..|...||....||.|..::...::.:...:..|:.|    :||.|.....
 Frog  1391 VLKPVLENVKEENNKLKEQAEEYCSKINELNEELQMFSERDLKNDGYAEVK----QLQEKMLATI 1451

  Fly  1000 ANKQESQEVL-TLKTSLAHLKSKVCELQKKLEK--QSEDE-------------KISELQSDIGEI 1048
            ..|:|.||:| :|:.....|:   |.||:.:|.  :::||             .:.||:|   ::
 Frog  1452 QEKEELQEILGSLRAERDELR---CNLQENIEMSIETQDELRNVLDELKRKTQLLDELKS---QV 1510

  Fly  1049 SECCLSMELKLADIVNWQAEELRPLDQLQESGVELQHHSTTAEESLNVEKPIQEQTERTLTTEYE 1113
            ::|....|..|.|..:.|.:|            .|:|||......|..|:...:|.:
 Frog  1511 NQCNTQDEQSLGDGDDIQNKE------------ALKHHSDQYSAELAEERANTQQLQ-------- 1555

  Fly  1114 RRIEQLEESLQRAQEELSILEKRKTDEN-KSLQLEYMAKIETSENENRSKFR-AYCLD-LKETQK 1175
               .||||.|::.:|:.::|  :...|| :....:|...:||.|.....|.: ...|| |:.|.:
 Frog  1556 ---NQLEEKLRKMEEQENLL--KSISENLQDTSSKYEKAVETLELVTMEKDQLLVTLDSLRLTTE 1615

  Fly  1176 RYEEQLQQTNEKLASVTTQCQVHLDVIKRSLQEKITQAEKERNELAVRHKAELE----KIRETLK 1236
            ...::|:...::....||      :..|...::..||.|:|.   |.:...|||    |..:.||
 Frog  1616 TLTKELESHKQEALHCTT------NQTKPETEQSNTQLEEEN---AAKKVEELEHQLSKTLDILK 1671

  Fly  1237 EKESSY---KEKLRQAEEERDKEISRLEVMR------------------------NTIAELHKTN 1274
            |:||.|   ||.|.....|:::.:|.||.::                        .|:.|:|:|:
 Frog  1672 EEESKYEMAKETLALVNGEKEQLLSELESLKLAHELVIKELDLYRQVRESKDQDMQTLDEVHRTD 1736

  Fly  1275 SDREVELEGVKMEKCQLKKLYDKSMLELEQLQCTADQKSSDLLPGSSNENIDDLQKKCDQYVQDL 1339
            . :||.|..:|:|..:.:   .:|...|:||                :..:|...::.:|..|.:
 Frog  1737 V-KEVALSPMKLEWSEAE---SRSQESLQQL----------------HNQLDSAIQEREQLQQLI 1781

  Fly  1340 ELLRGEKAELLSEIQKINGQHSNTIKKLEEI--------EAEMITLTTQKELERCEIAE------ 1390
            ..||.||::|.:::||.. ||.|..:..||.        |.|::....:...||.||.:
 Frog  1782 LSLREEKSQLTTDLQKYT-QHENRCRLEEEFSGSQKLVDEIEILKAQLKAAEERLEIKDRDYFEL 1845

  Fly  1391 -----------KLET--------------------------FKSKEADIKEALHCAQL------- 1411
                       ||||                          ..|:|..::|.|...|.
 Frog  1846 VQTTKTSLVEGKLETPVQDDSVEGSTDQHSVKVEQDRSDQGSVSEEKVLEEKLESNQYLLKRLQE 1910

  Fly  1412 -RLHAYDKLVCEYERLKGCLSDSNKLSENLQKKVERLHAEQLALQEGI-------SGRDSEIKQL 1468
             :|...:||    |.|:..:.:|..|.:|||:::|.|..|.:.|:|.|       |....::::.
 Frog  1911 EKLELSNKL----EILQQEMEESVLLKDNLQQRLECLLNENILLKENIETAVRHQSDTHGQLQKS 1971

  Fly  1469 RSELK----------DAID------ENKTVREAKVGLENSLKAVQENMSAQEGQFKQKIADIKGS 1517
            :.||:          |:.|      |.:|..|....||..:..:.|.:. |:...:||:...|..
 Frog  1972 QQELEYHLQLANLGGDSSDNSPVTQEKETSTECMHPLEEKILLLTEELH-QKNNEQQKLQHEKEE 2035

  Fly  1518 VDELQIKLKS----------------------------------------------LQEVRDHLE 1536
            :::.|:||||                                              ||:..|||.
 Frog  2036 LEQAQVKLKSEVEHLVNSMMELQSSLESLQHEKHDTEQQRLALKQQMQVVTQEKEELQQAYDHLT 2100

  Fly  1537 SRNEELKRKLKD--------AQELQNMVDKERKL---NSSLREDFDKLEQTKLDLEEQLRAKKVE 1590
            :..::||..||:        ..|:|...::|:.|   |..|.:...||   |.::||.:::.|
 Frog  2101 AEVDQLKGDLKENIEMGLNFKNEMQQKTNEEQCLLNQNKELEQSQHKL---KCEIEELMKSLK-- 2160

  Fly  1591 IDRRSKELG-EVTKDCE----NIRSDLEA----------------QTNDFLKE--RETLNLTI-- 1630
                .|||. |..|:.|    |:..::||                ...|.|:|  ||.:.::|
 Frog  2161 ----DKELALETLKESEQKVINLGQEMEALMLEMEELKNSQRTVMAERDQLQEDLRENVEMSIET 2221

  Fly  1631 -SDLRLHNEQLLETSKNYLSDITA-----ANNLNLEMKKNLHDLT--KECKSLRSDL-QSKEEYF 1686
             .|||...|: |:..|:.:..:|:     ...::|...:.||::|  ||..|.|.|| |||:..|
 Frog  2222 QDDLRRTQEE-LQQQKDKVQQLTSQISVLEEKISLLENQILHNVTTMKETLSERDDLDQSKQHLF 2285

  Fly  1687 ------------------QTQKQLLDET--ISNLKEENRKMEEKLSSGNKALKE----------- 1720
                              |.:|:..|..  |.:|.|:...:||:|......|||
 Frog  2286 SEIETLSLSLKEKDFALEQAEKEKADAATKIIDLTEKIATIEEQLLQNATNLKETLYEKESLIHS 2350

  Fly  1721 ------DCEKLRSTLESKELILQQNKQELEERLTVINEKNGKNALLDAQLKSNETAFTSLRKAWI 1779
                  |.|.||.||:||:|.|.:.:|:.:|.:..:.......:.|:.|:..|.|....:
 Frog  2351 KEQLALDTEHLRQTLKSKDLALGEMEQDRDEAVNKVIALTENISFLEEQISENATTLNKV----- 2410

  Fly  1780 KQSLAIEAANKRSLEMEQKVDKRTREYEELRSTLKTREINF-RSEKERMDGT---------ISSL 1834
                 |:.....||..:|    .:.:.||||.:|||::... ::|||..|..         ||||
 Frog  2411 -----IDENESFSLSRQQ----FSSQMEELRESLKTKDFQLEKAEKEIGDAVNNIKDLTAKISSL 2466

  Fly  1835 LED--------KRNLEEKLCTVTELLAKLKRELPALHTQKVNGGDVSIELNSSNGSPTPAAVPAT 1891
            .|:        ...|.||     |.|:..|::|.:...|      :::.|||.:     .|:...
 Frog  2467 EEEILQSADIVNETLSEK-----ENLSHCKQQLASELEQ------LALTLNSRD-----HALVQA 2515

  Fly  1892 KKPLDCNSAECVPKKSSSLETAERKNRRMTAYDENRK 1928
            |:..|    |...|.:|..:.....::.|..:.::::
 Frog  2516 KREKD----EAANKVASLTDEIRMLSKEMDEFRDSKE 2548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	141/332 (42%)
		Motor_domain	8..310	CDD:277568	139/326 (43%)
		SMC_prok_B	<471..1270	CDD:274008	234/1138 (21%)
		Mplasa_alph_rch	924..1647	CDD:275316	209/937 (22%)
		CENP-H	1204..>1266	CDD:283493	22/92 (24%)
		CALCOCO1	<1489..1850	CDD:285171	120/506 (24%)
cenpe	XP_004911147.2	KISc_CENP_E	6..330	CDD:276825	140/328 (43%)
		SMC_prok_B	551..1422	CDD:274008	165/896 (18%)
		Smc	1374..2246	CDD:224117	211/952 (22%)
		Smc	1905..2671	CDD:224117	159/693 (23%)
		SMC_prok_B	2429..>3078	CDD:274008	34/140 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1690
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48183
Panther	1	1.100	-	-	O	PTHR47968
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5166
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.150