DRSC/TRiP Functional Genomics Resources

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Protein Alignment His1:CG33834 and HP1BP3

DIOPT Version :9

Sequence 1:NP_001027334.1 Gene:His1:CG33834 / 3771911 FlyBaseID:FBgn0053834 Length:256 Species:Drosophila melanogaster
Sequence 2:NP_001358981.1 Gene:HP1BP3 / 50809 HGNCID:24973 Length:553 Species:Homo sapiens


Alignment Length:401 Identity:85/401 - (21%)
Similarity:130/401 - (32%) Gaps:173/401 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 EKKVGQKK-----ASGSAGTKAKKASATPSHPPTQQMGDA----SIKNLKERGGSSLLAIKKYIT 76
            ||||  ||     |:.||...|:....||.....:...||    :||...::.|:|::||:|||.
Human   126 EKKV--KKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYII 188

  Fly    77 ATY-KCDAQKLAPFIKKYLKSAVVNGKLIQTKGKGASGSF----KLSASAKKEKDPKAKSKVLSA 136
            ..| ..:.::....:|:.||..:..|.:.|.|||||||||    |...:.:|.::.|.:|..:..
Human   189 HKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDP 253

  Fly   137 EKKV-------------------------------------------------------QSKKVA 146
            |.:|                                                       |.:::.
Human   254 EPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQIT 318

  Fly   147 SK------KIGVSSKKTAVG------------AADKKPKAKKAVATKK-TAEN------------ 180
            .|      ::..|.:|..:|            ||..:||.....|.|| ..||            
Human   319 GKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHL 383

  Fly   181 -KKT---------------------------------------------------EKAKAKDAK- 192
             |||                                                   :::..:|:: 
Human   384 LKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSED 448

  Fly   193 -----KTGIIKSKPAATKAKVTAAK-------PKAVIAKASKAKPAVSAKPKKTVKKASVSATAK 245
                 |..:.|..||.:..|..:.|       ||...|:..||:|.    |||...||  ...||
Human   449 EEPPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPL----PKKAPPKA--KTPAK 507

  Fly   246 KPKAKTTAAKK 256
            |.:..:|..||
Human   508 KTRPSSTVIKK 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
His1:CG33834NP_001027334.1 Linker_histone 46..118 CDD:278939 27/80 (34%)
HP1BP3NP_001358981.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..134 6/9 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..159 5/18 (28%)
H15 155..245 CDD:238028 28/89 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..255 4/24 (17%)
H15 253..319 CDD:197772 3/65 (5%)
PxVxL motif. /evidence=ECO:0000303|PubMed:20042602 255..259 1/3 (33%)
Linker_histone 346..411 CDD:395429 12/64 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..553 24/103 (23%)
valS <455..531 CDD:237855 22/70 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4012
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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