DRSC/TRiP Functional Genomics Resources

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Protein Alignment eys and crb2a

DIOPT Version :9

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:NP_001038764.1 Gene:crb2a / 723994 ZFINID:ZDB-GENE-060612-1 Length:1466 Species:Danio rerio


Alignment Length:1923 Identity:401/1923 - (20%)
Similarity:573/1923 - (29%) Gaps:833/1923 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 CLSNPCVFG-VCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEG 211
            |.|:||..| :|:||:| .|.|:|:.||.|..|:.:.:||.|.||.|.|||::|...|.|.|..|
Zfish   178 CDSHPCQNGAICLDGVN-KYQCFCVPGYQGHNCEIDINECASRPCWNNGTCINGKDRYLCDCLLG 241

  Fly   212 FSGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGEC 276
            ::|.|||..:|||.|||||||..|.|....|.|.|..|:.||.||:::..||:|.   ||:||.|
Zfish   242 YTGVNCELEIDECESNPCQNGATCHDLVGLYTCDCVQGFEGSDCEINIDECESGP---CQNGGLC 303

  Fly   277 ---IEGPGLEFTCDCP-AGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEE 337
               |:    .:.|:|. .|:.|..|:|:|.||||.|||:||.|::.:..|.|:|..|:.|.|||.
Zfish   304 HDRID----SYECECEGTGYMGDHCEEDIPECASHPCQHGGTCLEGINHYNCSCWPGFEGGNCEV 364

  Fly   338 EILICADNPCQNNALCLMEEGVP-----------------TCYCVPDYHGEKCEFQYDECQLGPR 385
            :|..|||.||:|:..| .|:..|                 .|.|.|.|.||.|....:||...| 
Zfish   365 DIDECADAPCENDGEC-FEKSNPEHWETDWEFTYATAVGYVCQCQPGYTGENCSVNINECVSEP- 427

  Fly   386 CMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVR 450
            |.|||.|.|.|:.:.|.||...||:.||..:...||                             
Zfish   428 CHNGGSCKDLVNGYMCECPEGFTGVECEVNIDECES----------------------------- 463

  Fly   451 PVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGS 515
                                                :|..:....|:||:               
Zfish   464 ------------------------------------APCLNGGVCEDGVA--------------- 477

  Fly   516 HSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEES 580
                                   |.|.|.         .|.||.::|.                 
Zfish   478 -----------------------EYKCHC---------AEAEEGLLPW----------------- 493

  Fly   581 PSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITI 645
                       |.||                 .||......|.:.::|:        |..|.:  
Zfish   494 -----------GGPQ-----------------CTVQLLGCIGHECQNGA--------TCLPWL-- 520

  Fly   646 SVDITSSGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTF- 709
              |..:.|.:...          .|.|...|.:|:|:.|.           ::||...:..|:. 
Zfish   521 --DGETHGHTCLC----------PPGFYDDVCSIQTTFSF-----------SSPRFFLIELPSLE 562

  Fly   710 ------APEPPLDVVETTASTHHLWTEVPTTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVT 768
                  .||.||.|                 ...|.|..|..:|.  .|.:|..|.:::...|..
Zfish   563 RRRRETEPEHPLGV-----------------RLRFRTTLPDMLLF--FRGNAEFFLSLEIVGGEL 608

  Fly   769 TTSPT--EDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTT---- 827
            ....|  |:.|:|...|.    :|:..|.:|.|.::          :.|......:.:|..    
Zfish   609 RARATSKEEGSLEAQLPG----LVSDGDWHEAIVNI----------NEHDIRLVLQVKGANCNNQ 659

  Fly   828 ---LQPLEEDEHHHHHHHDEFT------TPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAE 883
               ::...:|.|....|||..|      .|   |...|..|..:..:|..|...|...       
Zfish   660 ACRVEDKLQDGHETFLHHDSLTKVYVGGVP---EEYIGLTLSGQGFLGCMEDLQVDGH------- 714

  Fly   884 TTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPP 948
                                                         |.||..|             
Zfish   715 ---------------------------------------------PVLPHDL------------- 721

  Fly   949 TIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVP 1013
                                                                     |.      
Zfish   722 ---------------------------------------------------------GH------ 723

  Fly  1014 EEKAGDVDCIKL--------GCYNGGTCVTTSEGSRCVCRFDRQGPLC--ELPIIIRNAAF---S 1065
            ||::.::.|:|.        .|...|.||......||.|.....|..|  ::|    ...|   :
Zfish   724 EEESVELGCVKTEWCQEDPQPCSQQGHCVDLWTSYRCDCYRPHYGQDCSKDMP----TWTFGHEN 784

  Fly  1066 GDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIM---LAAAQGTKGGHYMALFLQKGL 1127
            ..|:::..:..|.|.:.|:...|        |:..::||:.   .:..|||:...|..::|:.|.
Zfish   785 STSFLAFELLSDFGSNFSVSFFL--------RSLKSSGLLFQLRRSGVQGTEDEPYFTIYLEMGR 841

  Fly  1128 MQFQFSCGLQTMLLSELETP-------VNTGHEITIRAEL-DFSRNYTHCNASLLVNDTLAMSGD 1184
            :|          :.|..|:|       |:.|.:..::.:: |....:.|              |.
Zfish   842 LQ----------VTSMAESPILSSPVFVSNGEKPLLQVDIQDGQVFFNH--------------GG 882

  Fly  1185 QPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRI-------- 1241
            ....|.|||..    |.:....|::||.|.       |......|..|.|||..||:        
Zfish   883 YRYGLGLLPDL----EVLEGDLLYIGGVPG-------EEGATVWGGHFKGCLQDLRLDDVHLDVE 936

  Fly  1242 --NGQAREIFGDALDGFGITE-CGS-LACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTG 1302
              |....|....|.|...:.. |.| ..|...||.||.|| .:..||          :.|.||..
Zfish   937 DWNNTLSESIYIASDSENVLPGCTSDDTCKMEPCLNGGAC-TVTWND----------FICSCPKD 990

  Fly  1303 YMGPTCEISV-CEDNPCQYGGTCVQFPGSGYLCLC-------PLGKHGHYCEHNLEVALPSFSGS 1359
            :.|.|||..| |..:||..||.||... .|:.|:.       ||    ||          |..||
Zfish   991 FTGKTCETRVWCVSDPCINGGHCVDLL-DGFECIANATFDNTPL----HY----------SAKGS 1040

  Fly  1360 VNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQ---------SGYHDEKSDHLA-- 1413
            :              |:....::.|:..:..:.:.|.|:.|:         |..|.|  .|.|  
Zfish  1041 L--------------LDPVTNVTMKLRTRQENGVLLRAWRGEELLLIGLLDSSIHVE--IHTANS 1089

  Fly  1414 ---VSFIQGYIMLTWNLGAGPRRIF--TQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNIT 1473
               |.|            :|.|||.  ....:.|.:..|.        ....|.::.|||..:  
Zfish  1090 VEPVKF------------SGQRRIADGNWHRLLFAMAHPE--------HDASQWFVLVDGIID-- 1132

  Fly  1474 GRSPGSGSRMDVLPILYLGGHEIANF-NTLPHDLPLHSGFQGCIYDVQLKAGQVTVPL------- 1530
                ||.:     |:  |.|.  .|| ..:..::.|...|.||:..|  :.|.|.:|.       
Zfish  1133 ----GSSA-----PV--LAGS--LNFLKDISSEVALAETFTGCLGAV--RVGGVYLPFVDNTKSP 1182

  Fly  1531 QETRGVRGRG----VGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDS-- 1589
            |.||..|...    :|..|...|..|.|:..|.|:.....|.|.|..||.|.:|.:..:.|.|  
Zfish  1183 QTTRFWRRPDEHVHLGCFGAPVCRSHPCRRGGTCVDLFNKFGCKCPSGWEGNICEKEIDECISGP 1247

  Fly  1590 -FNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKL 1653
             .:.||.:.      :||::|.|..|..|..|.|.|                          |..
Zfish  1248 CLHGKCKDK------LNGFDCLCHPGYAGPTCSENI--------------------------DDC 1280

  Fly  1654 GAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFF 1718
            ...|.:                                                           
Zfish  1281 KGSRCK----------------------------------------------------------- 1286

  Fly  1719 IEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEW 1783
                                               .||..                         
Zfish  1287 -----------------------------------NGGTC------------------------- 1291

  Fly  1784 HKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCV 1848
                                                   :.|:.|.:                |:
Zfish  1292 ---------------------------------------VDGVNDFT----------------CI 1301

  Fly  1849 RGLVVSGTRIVLNETNIVESRNIRDCDGTACGGD-SCESGGHCWLDEKLQPHCICPEYAKGDRCE 1912
            .....||||...|...:            .|..| .||:.|.|. |.....:|.||....|:|||
Zfish  1302 CPPKYSGTRCQYNYPPL------------KCALDVECENDGVCH-DTPWGANCTCPPGFTGERCE 1353

  Fly  1913 YS-ETCKLIPCKNNGRCL-RSGR--CSCPNGWGGFYCE 1946
            .. :.|...||.|.|.|| |..|  |.||.|:.|.:||
Zfish  1354 REIDECASSPCLNGGSCLDRLNRFQCLCPAGFSGQFCE 1391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 16/33 (48%)
EGF_CA 220..256 CDD:238011 18/35 (51%)
EGF_CA <270..298 CDD:238011 10/31 (32%)
EGF_CA 301..336 CDD:238011 17/34 (50%)
EGF 342..371 CDD:278437 13/45 (29%)
EGF_CA 378..413 CDD:238011 15/34 (44%)
Laminin_G_2 1096..1244 CDD:280389 36/168 (21%)
EGF_CA 1314..1346 CDD:238011 12/38 (32%)
LamG 1355..1521 CDD:238058 37/182 (20%)
EGF 1549..1578 CDD:278437 10/28 (36%)
EGF_CA 1585..1621 CDD:238011 10/38 (26%)
Laminin_G_2 1723..1856 CDD:280389 6/132 (5%)
LamG 1956..2144 CDD:238058
crb2aNP_001038764.1 EGF_CA 32..69 CDD:238011
EGF_CA 97..133 CDD:238011
EGF_CA <144..172 CDD:238011
EGF_CA 174..210 CDD:238011 15/32 (47%)
EGF_CA 212..248 CDD:238011 16/35 (46%)
EGF_CA 251..286 CDD:238011 18/34 (53%)
EGF_CA 288..325 CDD:238011 13/43 (30%)
EGF_CA 327..363 CDD:238011 17/35 (49%)
EGF_CA 365..416 CDD:238011 16/51 (31%)
EGF_CA 419..455 CDD:238011 15/36 (42%)
Laminin_G_2 580..714 CDD:280389 32/152 (21%)
LamG 786..929 CDD:238058 40/185 (22%)
EGF_CA <969..997 CDD:238011 13/38 (34%)
LamG 1046..1168 CDD:238058 33/160 (21%)
EGF_CA <1208..1237 CDD:238011 10/28 (36%)
EGF_CA 1240..1273 CDD:238011 10/38 (26%)
EGF_CA 1276..1312 CDD:238011 12/235 (5%)
EGF_CA 1320..1353 CDD:238011 12/33 (36%)
EGF_CA 1356..1391 CDD:238011 14/34 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170581671
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.840

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