DRSC/TRiP Functional Genomics Resources

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Protein Alignment eys and Notch3

DIOPT Version :10

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:NP_064472.3 Gene:Notch3 / 56761 RGDID:620761 Length:2319 Species:Rattus norvegicus


Alignment Length:1903 Identity:347/1903 - (18%)
Similarity:458/1903 - (24%) Gaps:994/1903 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 SNPCV-FGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGFS 213
            :|||. .|.|:: ...|:.|.|..||||.:|:|:.:||.|.||:|..||:|.:..:.|.|..||:
  Rat   401 ANPCEHLGRCVN-TQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFT 464

  Fly   214 GSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIE 278
            |:.||.::|||.|:||.|||:|:||.||:.|||..|:.||.|:|||..|   ....|::|.:|::
  Rat   465 GTFCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDEC---ASTPCRNGAKCVD 526

  Fly   279 GP-GLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILIC 342
            .| |.|  |.|..|:.|.:|:..:::|:..||.:|. |||.:|:::|||..|||||.||.::..|
  Rat   527 QPDGYE--CRCAEGFEGTLCERNVDDCSPDPCHHGR-CVDGIASFSCACAPGYTGIRCESQVDEC 588

  Fly   343 ADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLL 407
            ...||:....||.......|.|.|...|..||...|:|...| | ..|||.||::.:.|.|.|..
  Rat   589 RSQPCRYGGKCLDLVDKYLCRCPPGTTGVNCEVNIDDCASNP-C-TFGVCRDGINRYDCVCQPGF 651

  Fly   408 TGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIV 472
            ||.||.                                                           
  Rat   652 TGPLCN----------------------------------------------------------- 657

  Fly   473 VTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQE 537
                  .|:.....||.....|..:|             |:|.|.:.                  
  Rat   658 ------VEINECASSPCGEGGSCVDG-------------ENGFHCLC------------------ 685

  Fly   538 PESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSES 602
                                          ||.|               ||||            
  Rat   686 ------------------------------PPGS---------------LPPL------------ 693

  Fly   603 SGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTT 667
                     ...|.|                   |.|....:..|...:.|......|       
  Rat   694 ---------CLPVNH-------------------PCAHKPCSHGVCHDAPGGFQCVCE------- 723

  Fly   668 PAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTAST---HHLWT 729
                                      |..:.||......|......|.....|..|.   .|   
  Rat   724 --------------------------PGWSGPRCSQSLAPDACESQPCQAGGTCTSDGIGFH--- 759

  Fly   730 EVPTTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILD 794
               .|.||.|..:..|||                                  :|.||.:.     
  Rat   760 ---CTCAPGFQGHQCEVL----------------------------------SPCTPSLC----- 782

  Fly   795 SNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPL 859
                                                    ||..|...|                
  Rat   783 ----------------------------------------EHGGHCESD---------------- 791

  Fly   860 QTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAP-----VPPATTTPPP 919
                                 |.:.||             .:.||....|     |.......|.
  Rat   792 ---------------------PDQLTV-------------CSCPPGWQGPRCQQDVDECAGASPC 822

  Fly   920 SPPSLATETPTLPPTLPPV-----TLPPVTQPPPTIPPTPP-------------STQSAQTLPPP 966
            .|....|   .||.:...:     |.|...|......|.|.             |.........|
  Rat   823 GPHGTCT---NLPGSFRCICHGGYTGPFCDQDIDDCDPNPCLNGGSCQDGVGSFSCSCLSGFAGP 884

  Fly   967 TSAINV---YTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCY 1028
            ..|.:|   .::|.||.|.:....|.|            .|...|.||...| ...:||....|:
  Rat   885 RCARDVDECLSSPCGPGTCTDHVASFT------------CTCPPGYGGFHCE-TDLLDCSPSSCF 936

  Fly  1029 NGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQ 1093
            ||||||.......|:||                ..::|                       .|.|
  Rat   937 NGGTCVDGVNSFSCLCR----------------PGYTG-----------------------THCQ 962

  Fly  1094 LKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRA 1158
            .||.                                   .|..:..|...:..|.::|.|.|.|.
  Rat   963 YKVD-----------------------------------PCFSRPCLHGGICNPTHSGFECTCRE 992

  Fly  1159 ELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIEL 1223
              .|:.|  .|.             :...|....|.:              .|......|.....
  Rat   993 --GFTGN--QCQ-------------NPVDWCSQAPCQ--------------NGGRCVQTGAYCIC 1026

  Fly  1224 PPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLAC----------LSSPCRNGAACI 1278
            ||..||.                           :.:..||.|          |...|:.|..||
  Rat  1027 PPEWSGP---------------------------LCDIPSLPCTEAAAHMGVRLEQLCQAGGQCI 1064

  Fly  1279 KIETNDLDENGEKAEKWKCKCPTGYMGPTC--EISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKH 1341
                       :|.....|.||.|.||..|  |:..|...|||:||||..:.| ||:|.||.|..
  Rat  1065 -----------DKDHSHYCVCPEGRMGSHCEQEVDPCTAQPCQHGGTCRGYMG-GYVCECPAGYS 1117

  Fly  1342 GHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHD 1406
            |..||.:::                                                        
  Rat  1118 GDSCEDDVD-------------------------------------------------------- 1126

  Fly  1407 EKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFN 1471
                                                                             
  Rat  1127 ----------------------------------------------------------------- 1126

  Fly  1472 ITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGV 1536
                                                                             
  Rat  1127 ----------------------------------------------------------------- 1126

  Fly  1537 RGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPC------DSFNNKCY 1595
                       ||....||:.|:|:...|.:.|.|..|..|.||....:.|      || ..:|.
  Rat  1127 -----------ECASQPCQNGGSCIDLVAHYLCSCPPGTLGVLCEINEDDCGPGPSLDS-GLRCL 1179

  Fly  1596 EDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQM 1660
            .:.|||.||.|:.|:||.|.||.:||..|...                                 
  Rat  1180 HNGTCVDLVGGFRCNCPPGYTGLHCEADINEC--------------------------------- 1211

  Fly  1661 VSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRP 1725
                         :|.|..::|                                           
  Rat  1212 -------------RPGTCHAAH------------------------------------------- 1220

  Fly  1726 LSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQ 1790
                       |.:..||....|..:.|.|      .:||                         
  Rat  1221 -----------TRDCLQDPGGHFRCICLPG------FTGP------------------------- 1243

  Fly  1791 RGRWLTLWVEGSASSALAPSAEVLVEP--------DSLLYIGGLKDVSKLPHNAISGFPIPFRG- 1846
                       ...:||.|...   :|        .||...|||........        ||.| 
  Rat  1244 -----------RCQTALFPCES---QPCQHGGQCRPSLGRGGGLTFTCHCVQ--------PFWGL 1286

  Fly  1847 -CVRGLVVSGTRIVLNETNIVESRNIRD--------CDGTACGGDSCESGGHCWLDEKLQPHCIC 1902
             |.|                 .:|:.|:        |..||.|                 |.|.|
  Rat  1287 RCER-----------------VARSCRELQCPVGIPCQQTARG-----------------PRCAC 1317

  Fly  1903 PEYAKGDRCEYSE---------TCKLIPCKNNGRCLRSG-----RCSCPNGWGGFYCEIAMSKPT 1953
            |....|..|..|.         :|...||.:.|.||...     ||.|..||||..||...:.|.
  Rat  1318 PPGLSGPSCRVSRASPSGATNTSCAATPCLHGGSCLPVQSVPFFRCVCAPGWGGPRCETPSAAPE 1382

  Fly  1954 TPSFRGNSYLILPPPRIP 1971
            .|.          .||.|
  Rat  1383 VPE----------EPRCP 1390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 14/33 (42%)
EGF_CA 220..256 CDD:238011 20/35 (57%)
EGF_CA <270..298 CDD:238011 10/28 (36%)
EGF_CA 301..336 CDD:238011 16/34 (47%)
EGF 342..371 CDD:394967 8/28 (29%)
EGF_CA 378..413 CDD:238011 15/34 (44%)
Laminin_G_2 1096..1244 CDD:460494 19/147 (13%)
EGF_CA 1314..1346 CDD:238011 15/31 (48%)
LamG 1355..1521 CDD:238058 0/165 (0%)
EGF 1549..1578 CDD:394967 9/28 (32%)
EGF_CA 1585..1621 CDD:238011 16/41 (39%)
Laminin_G_2 1723..1856 CDD:460494 22/142 (15%)
LamG 1956..2144 CDD:238058 3/16 (19%)
Notch3NP_064472.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
EGF_CA 160..197 CDD:238011
EGF_CA 238..274 CDD:238011
EGF_CA 276..313 CDD:238011
EGF_CA 316..351 CDD:238011
EGF_CA 393..431 CDD:238011 12/30 (40%)
EGF_CA 433..469 CDD:238011 14/35 (40%)
EGF_CA 471..507 CDD:238011 20/35 (57%)
EGF_CA 509..545 CDD:238011 13/40 (33%)
EGF_CA 547..582 CDD:238011 16/35 (46%)
EGF_CA 585..620 CDD:238011 9/34 (26%)
EGF_CA 622..656 CDD:238011 14/35 (40%)
EGF_CA 660..>688 CDD:238011 8/88 (9%)
EGF_CA 698..731 CDD:238011 8/84 (10%)
EGF_CA 738..772 CDD:238011 8/39 (21%)
EGF_CA 812..848 CDD:238011 8/38 (21%)
EGF_CA 851..886 CDD:238011 4/34 (12%)
EGF_CA 889..924 CDD:238011 11/46 (24%)
EGF_CA 931..962 CDD:238011 12/69 (17%)
EGF_CA 965..1000 CDD:238011 10/73 (14%)
EGF_CA 1087..1122 CDD:238011 16/35 (46%)
EGF_CA 1124..1160 CDD:238011 12/232 (5%)
EGF_CA 1173..1205 CDD:238011 15/32 (47%)
NL 1382..1419 CDD:197463 4/19 (21%)
LNR 1 1389..1429 1/2 (50%)
NL 1423..1460 CDD:197463
LNR 2 1430..1467
LNR 3 1469..1507
Notch 1476..1502 CDD:459658
NOD 1507..1562 CDD:462014
NODP 1579..1639 CDD:462229
JMTM_Notch3 1620..1711 CDD:411987
ANK repeat 1790..1838 CDD:293786
ANKYR 1820..2028 CDD:440430
ANK repeat 1840..1871 CDD:293786
ANK 1 1840..1869
ANK repeat 1873..1905 CDD:293786
ANK 2 1873..1903
ANK repeat 1907..1938 CDD:293786
ANK 3 1907..1936
ANK repeat 1940..1971 CDD:293786
ANK 4 1940..1969
ANK repeat 1973..2004 CDD:293786
ANK 5 1973..2002
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2026..2046
PHA03247 <2029..2316 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2059..2129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2197..2319
Blue background indicates that the domain is not in the aligned region.

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