DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eys and agrn

DIOPT Version :9

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:XP_021325504.1 Gene:agrn / 565373 ZFINID:ZDB-GENE-030131-1033 Length:2056 Species:Danio rerio


Alignment Length:2441 Identity:499/2441 - (20%)
Similarity:753/2441 - (30%) Gaps:854/2441 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PLTANGATTTG----LSVTLAPKDMQRNHLLKMPTATIEKPTITATIASSSSTSTSTTRKSVTAT 107
            |...:....||    ..|.|||:.|..||                                   .
Zfish   100 PHICDNQVATGDTRIFFVNLAPEYMWPNH-----------------------------------K 129

  Fly   108 RSLKLNPNILLPTLRIL-----------------------------ARGLL--LPALILAILVGS 141
            ..|.||.:::..|||.|                             .||.|  ..|:........
Zfish   130 NELMLNSSLMRITLRNLEEVEHCVEDHKMIIADKPVHFTPAPPPDGCRGKLCGFGAVCERDQADP 194

  Fly   142 SQAGFACLSNPC---VFGVCIDGLNSS-YSCYCIDGYTGIQCQTN-------------WDECWSS 189
            |:....|....|   |..||  |.:|| ||..|  .....||.|.             .|.|...
Zfish   195 SKGECVCKKIVCTSVVAPVC--GSDSSTYSNEC--ELEKAQCNTQRRIKVMRKGPCALKDPCSEV 255

  Fly   190 PCQNGGTCV---DGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYL 251
            .|..|.||:   ||:: ..|.||     .:| |||.:.:  .|.:.||...              
Zfish   256 TCSFGSTCIQSSDGLS-AKCMCP-----LSC-ENVPKHV--VCGSDGLDYQ-------------- 297

  Fly   252 GSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECA----------- 305
             |.|||::..|.|....|..|.|.|  .|                |.:.:|..:           
Zfish   298 -SECELNMKACATQKNIRVHHQGRC--DP----------------CSDTLNSLSTACRVNPKTYQ 343

  Fly   306 --------SSPCQNGGVCVDKLAAYACACPMGYTGI------------NCEEEILICADNPCQNN 350
                    |.|.....:|......|...|.|..|.:            :|:|:  ....|.|:.|
Zfish   344 QITFAPAESCPPDEMPICASDGHTYESMCQMERTALKNNLELKKVSLGSCKEK--GGCPNGCKFN 406

  Fly   351 ALCLMEEGVPTCYCVP---------------DYHGEKCEFQYDEC---------QLGP------- 384
            |:||::.|...|.|.|               ..:...||.:..||         |.||       
Zfish   407 AICLLDNGEFRCSCDPIQCDGTYKPLCGKDGKTYPNDCERKLQECRTQKDIPVKQQGPCDLNLES 471

  Fly   385 -----RCMNGGVCI------------------------DGVDTFSCSCPPLLTGMLCECLM---- 416
                 .|..|.||:                        || .|:|.||.....|    |.:    
Zfish   472 PCLKKTCEFGAVCVVKNSEAVCECSDACPQDQDPVCGSDG-HTYSSSCQMKAMG----CALQKQI 531

  Fly   417 --------VGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVV 473
                    ..|...:|::.|.......|.......:  .|.:||...:.|...:.....|:  ..
Zfish   532 QMQHKGPCADESCTNCSFGAICDAQTGRCVCPKGCL--ETRQPVCGSDGTTYDNECKLNVQ--AC 592

  Fly   474 TTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSIS----VEQTTAVPAQPEPES 534
            |.....:||.             .|   |.||........||..::    .:|.|..|.:|...|
Zfish   593 TKQLDLKVVA-------------HG---ECKTCGSTVCSWGSQCVNNKCECQQCTGQPVKPVCGS 641

  Fly   535 EQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSAS 599
            :                           |.|.........:|.::...|....|.:..:...|..
Zfish   642 D---------------------------GNTYNNDCELRLASCQKQRKIEVAKPGVCDEDCGSGG 679

  Fly   600 SESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEV 664
            |.|..|....:.....      |...:...|:...|.......:..|....|.|::.||...:  
Zfish   680 SGSGSETCEQDRCRRY------GGTWDDDMEDERCVCELNCQIVLHSPVCGSDGNTYSSDCEL-- 736

  Fly   665 FTTPAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWT 729
                      :.|..|..|.:...:..|.|...:|             ||    |..||.|...|
Zfish   737 ----------KKTRCEKQIDLSVQSQGPCPTIVSP-------------PP----ELVASQHCSQT 774

  Fly   730 -----EVPTTAA--------PFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSP--------- 772
                 |...|||        |...:       ..|..|.|  .|..|..|..:..|         
Zfish   775 VYGCCEDNKTAALGVGLAGCPSMCQ-------CNHYGSYG--GTCDPSTGQCSCKPGVGGLKCDR 830

  Fly   773 ------------TEDSSVELP---------------------------------TPHTPQIVVTI 792
                        ||:.|...|                                 .|...::.|..
Zfish   831 CEPGFWNFRGIVTENMSGCTPCNCDGVGSVRDDCEQMSGLCSCKPGVKGMKCNVCPDGSKMGVNG 895

  Fly   793 LDSNEVIP----SLITTTGSPTTHHHHHHH---PHHE-----------AEGTTLQPLEEDEHHHH 839
            .|.....|    .|:...||.....:...|   |..:           ::|.|            
Zfish   896 CDKGPKAPKSCAELVCHFGSSCVEVNGQAHCECPSPDCDEKNKTKVCGSDGVT------------ 948

  Fly   840 HHHDE-----FTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLG 899
             :.|.     ....|..||...|..|.::.|                 |.|..|...|.|    .
Zfish   949 -YADRCQLKTIACRQDKEIKVEHLGQCKESI-----------------ELTAKPTPFPTT----H 991

  Fly   900 TAAPPATPAPVPP-----ATTTPPPSPPSLATETPTLPPTLPPVTL-------PPVTQPPPTIPP 952
            ...||.....|..     .|||    |.|...|      .:||..|       .|.|...||.|.
Zfish   992 RTTPPTAHVKVTKQRHGHRTTT----PDSYVVE------AMPPPRLDGARKFSSPFTTHRPTTPY 1046

  Fly   953 TPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPS-VTESSEEVEGTNTVSTGGRGSGGVP-EE 1015
            .|..|.|     ||   ::...:..|.|:......| :.||.||..||...:|      .:| .|
Zfish  1047 KPLRTSS-----PP---LDFDESGSGEPSGDDEMVSGMEESGEEPLGTTVATT------TLPTAE 1097

  Fly  1016 KAGDVDCIKLGCY-NGGTCVTTSEGSRC--VCRF------------------DRQGPLCELPIII 1059
            :....|....||. :|.|....|||:.|  ..||                  :.:.|..||   .
Zfish  1098 ERSSCDNTAFGCCPDGKTAAVNSEGTNCPSTMRFSGFLHLDKVEGQEVFYTPEMEDPKSEL---F 1159

  Fly  1060 RNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQ 1124
            ...|.|.:| ..:.:::.....:...:|       :||..:.:..|:         .|:.|.|..
Zfish  1160 GETARSIES-AMNELFRKSDVQKDFQSV-------RVRNLSPSNSII---------AHFEAHFDP 1207

  Fly  1125 KGLMQFQFSCG-LQTMLLSELETPVNTG------HEITIRAELDFSRNYTHCNASLLVNDTLAMS 1182
                ..:|:.| ::..||.:|:...:||      .|..||.     .||...........|..::
Zfish  1208 ----DTRFNVGDIEGALLKQLKASKDTGIVVKKPEEENIRI-----NNYGLSTVPFFTTTTTTVA 1263

  Fly  1183 GDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQARE 1247
            .            :.||.....|        .:|......|.|..:...||              
Zfish  1264 S------------VTTPTTTTTT--------MSPSSAYTTLRPITTRRPFT-------------- 1294

  Fly  1248 IFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISV 1312
                            .....:|....|..:...|..|               ...:||... |.
Zfish  1295 ----------------RTTTPAPATTTAPHVPKTTVSL---------------MNRLGPHAH-SP 1327

  Fly  1313 CEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSG-SVNGLSSFVAY-TVPIPL 1375
            |:..||::||||.: ..:.:.|:||.|:.|..||..::..:|||.| |.....:..|| ||.|.:
Zfish  1328 CDSQPCRHGGTCEE-DDNDFTCICPAGRGGAVCEKVIKYFIPSFGGKSYMAFQTMKAYHTVRIAM 1391

  Fly  1376 EYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPI 1440
            |:          :......:|.:.||.    .|.|.|:::.::||:.|.:|.|:|     |...|
Zfish  1392 EF----------RASEMTGILLYNGQK----SKKDFLSLTLVEGYVELRFNTGSG-----TASVI 1437

  Fly  1441 DFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHD 1505
            ...|..|...:::.|.|..|.|.||||.:.::.|:||.....:::...|::||    ..:.:..|
Zfish  1438 SKVLVKPGRWHQLVVVRNRRNAMLSVDNEPSVEGQSPPGTDGLNLDTDLFIGG----VLDDMSAD 1498

  Fly  1506 L----PLHSGFQGCIYDVQLKAGQVTVPLQETRG--VRGRGVGQCGTRECHRHACQHDGAC-LQH 1563
            :    .:.:|..|||.  .|....:...|||..|  :.|..:|:||...|..:.|::..:| ::.
Zfish  1499 VKERTSVSAGLVGCIR--MLDVNNLVYNLQENGGSVLYGSAIGECGNNPCLPNPCKNGASCQVKE 1561

  Fly  1564 GATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPL-VNGYECDCPVGRTGKNCEEVIRSL 1627
            ...|.|.|..|:.||.||...||||.  |||:..:.|..| ..||:|:||:||.|::||:|    
Zfish  1562 AEIFHCKCVNGFSGPTCADAHNPCDP--NKCHPPSRCQVLPEGGYKCECPMGREGRHCEKV---- 1620

  Fly  1628 SDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLL---N 1689
                                  .||.||          |.       |..|..|...:|.|   |
Zfish  1621 ----------------------SDKGGA----------FI-------PYFTGDSFLELKGLHTYN 1646

  Fly  1690 EVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQ 1754
            :..:|:....:.|:.:.|                     :|::.|.|   ...|.|..|:||||.
Zfish  1647 QDLRQKFSMTIVLLANDS---------------------KGMIFYNG---QKTDGKGDFISLSLN 1687

  Fly  1755 GGVVEFRI---SGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEG-SASSALAPSAEVLV 1815
            .|::|||.   .||:    |:||...:.:.||:.:.:.:..|...:.:.| ......||.:....
Zfish  1688 DGILEFRYDLGKGPA----VIRSKEKIKLNEWNTVNLERASRKGEISINGKDPVRGEAPKSRKNQ 1748

  Fly  1816 EPD----SLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDG 1876
            ..|    ..|::||..|..|:...|  .....|:|.::.:.:.|..| |...|.:.|.::.....
Zfish  1749 HTDLNLKESLFVGGAPDFRKVARAA--AIKDGFKGAIQKITLMGIPI-LKADNALSSTDVSMYPN 1810

  Fly  1877 TACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLIPCKNNGRCLRSGRCSCPNGWG 1941
            ..|..|.||:||.|      .|.                             |.|..|:|.:|:.
Zfish  1811 HPCSKDVCENGGRC------NPQ-----------------------------LNSYECACRHGFS 1840

  Fly  1942 GFYCEIAMSKPTTP-----SFRGNSYLILP--------PPRIPMKDKRRGPSLYVRPREAIQVS- 1992
            |.:|:..:.:.:..     :|.|::::...        ...||..:....||  .:..:|:.|: 
Zfish  1841 GHHCQDTIFEKSAGDTEAIAFDGHTFIEYHNGVTKSQLTNEIPDPESLENPS--DQSEKALLVNK 1903

  Fly  1993 --LNFSTIEPDGLLLWSEH--ERSKFLGLGLEAGHLKLASNLLGS------------TNDTVRAP 2041
              |:..|....||:|||..  |||.::.|.:..|.:::..: |||            ||..:|..
Zfish  1904 FELSIRTEATHGLILWSGKGVERSDYIALAIVDGRVQMTYD-LGSKPVVLRSTVRVNTNHWIRIK 1967

  Fly  2042 ASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTI 2106
            ||..:.||:              ||:..|...|     |...|.:|                 .:
Zfish  1968 ASRALRDGS--------------LQVGNEAAVT-----GSSPLAAT-----------------QL 1996

  Fly  2107 SYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDI 2142
            ..:...:|||.... ||:||....:...|.||::|:
Zfish  1997 DTDGALWLGGLEEL-SVARRLPKAYSTGFIGCVKDV 2031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 11/36 (31%)
EGF_CA 220..256 CDD:238011 6/35 (17%)
EGF_CA <270..298 CDD:238011 4/27 (15%)
EGF_CA 301..336 CDD:238011 8/65 (12%)
EGF 342..371 CDD:278437 10/43 (23%)
EGF_CA 378..413 CDD:238011 16/79 (20%)
Laminin_G_2 1096..1244 CDD:280389 27/154 (18%)
EGF_CA 1314..1346 CDD:238011 11/31 (35%)
LamG 1355..1521 CDD:238058 45/171 (26%)
EGF 1549..1578 CDD:278437 7/29 (24%)
EGF_CA 1585..1621 CDD:238011 17/36 (47%)
Laminin_G_2 1723..1856 CDD:280389 34/140 (24%)
LamG 1956..2144 CDD:238058 48/212 (23%)
agrnXP_021325504.1 NtA 43..146 CDD:308653 16/80 (20%)
KAZAL 200..246 CDD:197624 14/49 (29%)
KAZAL 276..321 CDD:197624 18/67 (27%)
KAZAL_FS 353..393 CDD:238052 6/39 (15%)
KAZAL 422..465 CDD:197624 7/42 (17%)
KAZAL 494..539 CDD:197624 8/49 (16%)
KAZAL 561..606 CDD:197624 9/64 (14%)
KAZAL 626..671 CDD:197624 10/71 (14%)
KAZAL 709..755 CDD:197624 9/57 (16%)
Laminin_EGF 798..840 CDD:278482 7/50 (14%)
Laminin_EGF 852..>888 CDD:278482 1/35 (3%)
KAZAL 932..974 CDD:197624 7/54 (13%)
SEA 1145..1228 CDD:307516 18/106 (17%)
EGF 1328..1356 CDD:306513 11/28 (39%)
LamG 1369..1519 CDD:238058 46/174 (26%)
Laminin_G_1 1663..1794 CDD:278483 37/161 (23%)
EGF_CA 1814..1845 CDD:238011 13/65 (20%)
Laminin_G_1 1908..2039 CDD:278483 39/162 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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