DRSC/TRiP Functional Genomics Resources

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Protein Alignment eys and NOTCH3

DIOPT Version :10

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:NP_000426.2 Gene:NOTCH3 / 4854 HGNCID:7883 Length:2321 Species:Homo sapiens


Alignment Length:1990 Identity:391/1990 - (19%)
Similarity:539/1990 - (27%) Gaps:914/1990 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 SNPCV-FGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGFS 213
            :|||. .|.|:: ...|:.|.|..||||.:|:|:.:||.|.||:|..||:|.:..:.|.|..||:
Human   399 ANPCEHLGRCVN-TQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFT 462

  Fly   214 GSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIE 278
            |:.||.::|||.|:||.|||:|:||.||:.|||..|:.||.|:|||..|   ....|::|.:|::
Human   463 GTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDEC---ASTPCRNGAKCVD 524

  Fly   279 GP-GLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILIC 342
            .| |.|  |.|..|:.|.:|...:::|:..||.:|. |||.:|:::|||..||||..||.::..|
Human   525 QPDGYE--CRCAEGFEGTLCDRNVDDCSPDPCHHGR-CVDGIASFSCACAPGYTGTRCESQVDEC 586

  Fly   343 ADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLL 407
            ...||::...||.......|.|.....|..||...|:|...| | ..|||.||::.:.|.|.|..
Human   587 RSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNP-C-TFGVCRDGINRYDCVCQPGF 649

  Fly   408 TGMLC-----EC----------LMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPET 457
            ||.||     ||          .:.||....|                   :.||...|      
Human   650 TGPLCNVEINECASSPCGEGGSCVDGENGFRC-------------------LCPPGSLP------ 689

  Fly   458 TVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPP------ESGSH 516
                                                            |...||      |..||
Human   690 ------------------------------------------------PLCLPPSHPCAHEPCSH 706

  Fly   517 SISVE-----QTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSS 576
            .|..:     :....|....|...|.       .:..|.||:               |.....:.
Human   707 GICYDAPGGFRCVCEPGWSGPRCSQS-------LARDACESQ---------------PCRAGGTC 749

  Fly   577 SEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAP 641
            |.:......|.||                             .|.|.:.|               
Human   750 SSDGMGFHCTCPP-----------------------------GVQGRQCE--------------- 770

  Fly   642 SITISVDITSSGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYVTPTPLPE----TTTPRVV 702
                                   ..:|.                   ||.|...    .:.|..:
Human   771 -----------------------LLSPC-------------------TPNPCEHGGRCESAPGQL 793

  Fly   703 PV---PRPTFAPEPPLDVVETTASTHHLWTEVPTTAAP--FFTEYPAEVLITTHRTSAGRFTTVQ 762
            ||   |:....|....||.|...         |....|  ..|........|.|    |.:    
Human   794 PVCSCPQGWQGPRCQQDVDECAG---------PAPCGPHGICTNLAGSFSCTCH----GGY---- 841

  Fly   763 PPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTT 827
                   |.|:.|.                 |.|:..|:.....||                   
Human   842 -------TGPSCDQ-----------------DINDCDPNPCLNGGS------------------- 863

  Fly   828 LQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVP 892
                                             .:|.:|              ....:.:|    
Human   864 ---------------------------------CQDGVG--------------SFSCSCLP---- 877

  Fly   893 ATIAPLGTAAP-------PATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPPTI 950
                  |.|.|       .....|..|.|.|     ..:|:.|.|.||                 
Human   878 ------GFAGPRCARDVDECLSNPCGPGTCT-----DHVASFTCTCPP----------------- 914

  Fly   951 PPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEE 1015
                                                                     |.||...|
Human   915 ---------------------------------------------------------GYGGFHCE 922

  Fly  1016 KAGDV-DCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIG 1079
            :  |: ||....|:||||||.......|:||....|..|:                         
Human   923 Q--DLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ------------------------- 960

  Fly  1080 GHESLDAVLP---MHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLL 1141
             ||: |..|.   :|           |.:..||..|                 |:.:|       
Human   961 -HEA-DPCLSRPCLH-----------GGVCSAAHPG-----------------FRCTC------- 988

  Fly  1142 SELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTW 1206
              ||                   ::|......||:           |....|.:           
Human   989 --LE-------------------SFTGPQCQTLVD-----------WCSRQPCQ----------- 1010

  Fly  1207 LHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACLSSPC 1271
               .|......|.....||     |::|.|..:|                           |.||
Human  1011 ---NGGRCVQTGAYCLCPP-----GWSGRLCDIR---------------------------SLPC 1040

  Fly  1272 RNGAACIKIETNDLDENG----EKAEKWKCKCPTGYMGPTC--EISVCEDNPCQYGGTCVQFPGS 1330
            |..||.|.:....|.:.|    ::.....|.||.|..|..|  |:..|...|||:||||..:.| 
Human  1041 REAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMG- 1104

  Fly  1331 GYLCLCPLGKHGHYCEHNLE--VALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQI 1393
            ||:|.|..|.:|..||.:::  .:.|...|.                               |.|
Human  1105 GYMCECLPGYNGDNCEDDVDECASQPCQHGG-------------------------------SCI 1138

  Fly  1394 SLLAFF------GQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYE 1452
            .|:|.:      |..|...|.::.              :.|.||       |:|   ..||..: 
Human  1139 DLVARYLCSCPPGTLGVLCEINED--------------DCGPGP-------PLD---SGPRCLH- 1178

  Fly  1453 IKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIY 1517
                                      :|:.:|:     :||...    |.|   |.::|.: |..
Human  1179 --------------------------NGTCVDL-----VGGFRC----TCP---PGYTGLR-CEA 1204

  Fly  1518 DVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQH-GATFTCICQEGWYGPLCA 1581
            |                      :.:|.:..||   ..|...|||. |..|.|:|..|:.||.|.
Human  1205 D----------------------INECRSGACH---AAHTRDCLQDPGGGFRCLCHAGFSGPRCQ 1244

  Fly  1582 QPTNPCDSFNNKCYEDATCVPLVN-----GYECDCPVGRTGKNCEEVIRSLSDVSL-TGRRSYLA 1640
            ...:||:|  ..|.....|.|...     .:.|.|.....|..||.|.||..::.. .|......
Human  1245 TVLSPCES--QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQT 1307

  Fly  1641 VRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGS 1705
            .|.|                        :...|..::.||.             |||...|...|
Human  1308 PRGP------------------------RCACPPGLSGPSC-------------RSFPGSPPGAS 1335

  Fly  1706 KSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVT 1770
            .:            .....|                          .|.||              
Human  1336 NA------------SCAAAP--------------------------CLHGG-------------- 1348

  Fly  1771 VVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHN 1835
               |.|...:..:.:...||.      |. |....|.|.:.||..||             :.|..
Human  1349 ---SCRPAPLAPFFRCACAQG------WT-GPRCEAPAAAPEVSEEP-------------RCPRA 1390

  Fly  1836 AISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDGTACGGDSCESGGHCWLD------- 1893
            |..        ..||                :.|..|:|:...||.|    ||.|.|.       
Human  1391 ACQ--------AKRG----------------DQRCDRECNSPGCGWD----GGDCSLSVGDPWRQ 1427

  Fly  1894 -EKLQPHCICPEYAKGDRCE---YSETCKL--IPCKNNGR-----------C---LRSGRC--SC 1936
             |.||    |.......||:   .|..|..  ..|...||           |   ...|||  .|
Human  1428 CEALQ----CWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGC 1488

  Fly  1937 PN---GWGGFYCEIAMSKPTTPSFRGNSYLI----LPPPRIPMKDKRRGPSLYVRPREAIQVSLN 1994
            ..   ||.|..|     ....|:......|:    |||..:    .|.......|....::.||.
Human  1489 NTEECGWDGLDC-----ASEVPALLARGVLVLTVLLPPEEL----LRSSADFLQRLSAILRTSLR 1544

  Fly  1995 FSTIEPDGLLLWSEHERSKFLGLGLE-AGHLKLASNLLGS 2033
            |........:::..|..|.    |.| ....:||..::||
Human  1545 FRLDAHGQAMVFPYHRPSP----GSEPRARRELAPEVIGS 1580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 14/33 (42%)
EGF_CA 220..256 CDD:238011 20/35 (57%)
EGF_CA <270..298 CDD:238011 10/28 (36%)
EGF_CA 301..336 CDD:238011 15/34 (44%)
EGF 342..371 CDD:394967 7/28 (25%)
EGF_CA 378..413 CDD:238011 16/39 (41%)
Laminin_G_2 1096..1244 CDD:460494 21/147 (14%)
EGF_CA 1314..1346 CDD:238011 14/31 (45%)
LamG 1355..1521 CDD:238058 25/171 (15%)
EGF 1549..1578 CDD:394967 11/29 (38%)
EGF_CA 1585..1621 CDD:238011 9/40 (23%)
Laminin_G_2 1723..1856 CDD:460494 20/132 (15%)
LamG 1956..2144 CDD:238058 17/83 (20%)
NOTCH3NP_000426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
EGF_CA 158..195 CDD:238011
EGF_CA 236..272 CDD:238011
EGF_CA 274..311 CDD:238011
EGF_CA 314..349 CDD:238011
EGF_CA 391..429 CDD:238011 12/30 (40%)
EGF_CA 431..467 CDD:238011 14/35 (40%)
EGF_CA 469..505 CDD:238011 20/35 (57%)
EGF_CA 507..542 CDD:238011 13/39 (33%)
EGF_CA 545..580 CDD:238011 15/35 (43%)
EGF_CA 583..618 CDD:238011 8/34 (24%)
EGF_CA 620..654 CDD:238011 14/35 (40%)
EGF_CA 657..>686 CDD:214542 6/47 (13%)
EGF_CA 810..846 CDD:238011 11/59 (19%)
EGF_CA 849..884 CDD:238011 11/110 (10%)
EGF_CA 887..922 CDD:238011 12/113 (11%)
EGF_CA 929..960 CDD:238011 11/30 (37%)
EGF_CA 1085..1120 CDD:238011 15/35 (43%)
EGF_CA 1122..1158 CDD:238011 8/66 (12%)
EGF_CA 1171..1203 CDD:238011 11/74 (15%)
Notch 1384..1418 CDD:459658 14/74 (19%)
LNR 1 1387..1427 14/67 (21%)
Notch 1425..1458 CDD:459658 8/36 (22%)
LNR 2 1428..1458 8/33 (24%)
LNR 3 1467..1505 9/42 (21%)
Notch 1474..1500 CDD:459658 8/25 (32%)
NOD 1505..1560 CDD:462014 10/58 (17%)
NODP 1577..1637 CDD:462229 2/4 (50%)
JMTM_Notch3 1618..1709 CDD:411987
ANK repeat 1788..1836 CDD:293786
ANKYR 1818..2043 CDD:440430
ANK repeat 1838..1869 CDD:293786
ANK 1 1838..1867
ANK repeat 1871..1903 CDD:293786
ANK 2 1871..1901
ANK repeat 1905..1936 CDD:293786
ANK 3 1905..1934
ANK repeat 1938..1969 CDD:293786
ANK 4 1938..1967
ANK repeat 1971..2002 CDD:293786
ANK 5 1971..2000
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2120
PHA03247 <2045..2318 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2190..2321
Blue background indicates that the domain is not in the aligned region.

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