DRSC/TRiP Functional Genomics Resources

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Protein Alignment eys and NOTCH2

DIOPT Version :10

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:NP_077719.2 Gene:NOTCH2 / 4853 HGNCID:7882 Length:2471 Species:Homo sapiens


Alignment Length:1942 Identity:386/1942 - (19%)
Similarity:553/1942 - (28%) Gaps:845/1942 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 LVGSSQA----GFA----------CLSNPCV-FGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECW 187
            |.||.|.    ||.          |..:||| .|.|....:.::.|.|:.|:.|..|:.|.|:|.
Human   201 LPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCP 265

  Fly   188 SSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNP--CQNGGLCRDRTNGYICTCQPGY 250
            :..|||||.|||||..|||.||..::|..|.|:||||:..|  |||||.|.:|..||.|.|..|:
Human   266 NHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGW 330

  Fly   251 LGSHCELDV-----AVCETGT------------------GARCQHGGECIEGP------------ 280
            .|..|..::     |.|..|:                  |..|.....||..|            
Human   331 SGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPL 395

  Fly   281 GLEFTCDCPAGWHGRICQEEINECA---SSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILIC 342
            ..::.|.||.|:.|..|.|:::|||   |:||::.|.||:...|:.|.|..||.|..||.:|..|
Human   396 NGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINEC 460

  Fly   343 ADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLL 407
            ..:||||:|.||.:.|..||.|:|.:.|..||.:.:|||..| |:|.|.|:|.|:.|.|.|||..
Human   461 HSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNP-CVNNGQCVDKVNRFQCLCPPGF 524

  Fly   408 TGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIV 472
            ||.:|:.     :..||:.|                                             
Human   525 TGPVCQI-----DIDDCSST--------------------------------------------- 539

  Fly   473 VTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQE 537
                                                 |..:|:..|.                  
Human   540 -------------------------------------PCLNGAKCID------------------ 549

  Fly   538 PESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSES 602
                 ||.                 |...:..|..:....||:.......|...|:.|....|  
Human   550 -----HPN-----------------GYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDS-- 590

  Fly   603 SGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTT 667
                     ||.:.:....|                                :..|.:..|.:::
Human   591 ---------YTCICNPGYMG--------------------------------AICSDQIDECYSS 614

  Fly   668 PAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVP 732
            |.         :.....||.|.                                           
Human   615 PC---------LNDGRCIDLVN------------------------------------------- 627

  Fly   733 TTAAPFFTEYPAEVLITTHRTSAGRFTTVQP-PAGVTTTSPTEDSSVELPTPHTPQIVVTILDSN 796
                                   |.....|| .:||......:|.:                   
Human   628 -----------------------GYQCNCQPGTSGVNCEINFDDCA------------------- 650

  Fly   797 EVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQT 861
                      .:|..|            |..:..:        :.:....:|.    .||.... 
Human   651 ----------SNPCIH------------GICMDGI--------NRYSCVCSPG----FTGQRCN- 680

  Fly   862 EDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLAT 926
               |.:.|.|    .:|.....|.:..|.....|.|.|                           
Human   681 ---IDIDECA----SNPCRKGATCINGVNGFRCICPEG--------------------------- 711

  Fly   927 ETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTE 991
                                                             |..|...||....:  
Human   712 -------------------------------------------------PHHPSCYSQVNECL-- 725

  Fly   992 SSEEVEGTNTVSTGGRGSGGVPEEK----AG------DVD---CIKLGCYNGGTCVTTSEGSRCV 1043
            |:..:.|..|        ||:...|    ||      :||   |:...|.|||||.....|.||.
Human   726 SNPCIHGNCT--------GGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCT 782

  Fly  1044 CRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLA 1108
            |:...:|..|::.|   :...|.........:.||.|: :...|||                   
Human   783 CKKGFKGYNCQVNI---DECASNPCLNQGTCFDDISGY-TCHCVLP------------------- 824

  Fly  1109 AAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASL 1173
                         :..|       :|  ||:|......|....   .:..|.....:||...|. 
Human   825 -------------YTGK-------NC--QTVLAPCSPNPCENA---AVCKESPNFESYTCLCAP- 863

  Fly  1174 LVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHT 1238
                  ...|.:.|        :...|.|....::.|.........:.|.||     ||:|.   
Human   864 ------GWQGQRCT--------IDIDECISKPCMNHGLCHNTQGSYMCECPP-----GFSGM--- 906

  Fly  1239 LRINGQAREIFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGY 1303
                 ...|...|              ||::||:||.:|:           :....:.|.|..|:
Human   907 -----DCEEDIDD--------------CLANPCQNGGSCM-----------DGVNTFSCLCLPGF 941

  Fly  1304 MGPTC--EISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPS--FSGS--VNG 1362
            .|..|  :::.|...||:.||||..:..| |.|.|..|..|.:||:|:.....|  |:|.  |:|
Human   942 TGDKCQTDMNECLSEPCKNGGTCSDYVNS-YTCKCQAGFDGVHCENNINECTESSCFNGGTCVDG 1005

  Fly  1363 LSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHD--EKSDHLAVSFIQGYIMLTW 1425
            ::||                        |.:..:.|.|....|:  |.|.|..::  :|    |.
Human  1006 INSF------------------------SCLCPVGFTGSFCLHEINECSSHPCLN--EG----TC 1040

  Fly  1426 NLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILY 1490
            ..|.|          .:|...|       :|..|:.....|    |:..|||.......|     
Human  1041 VDGLG----------TYRCSCP-------LGYTGKNCQTLV----NLCSRSPCKNKGTCV----- 1079

  Fly  1491 LGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQ 1555
               .:.|....|     ..||:.|...||.    .|:..:..:|    |||       ...|.||
Human  1080 ---QKKAESQCL-----CPSGWAGAYCDVP----NVSCDIAASR----RGV-------LVEHLCQ 1121

  Fly  1556 HDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNC 1620
            |.|.|:..|.|..|.|..|:.|..|.:..:.|.|  |.|...|||...:.||.|:|..|..|.||
Human  1122 HSGVCINAGNTHYCQCPLGYTGSYCEEQLDECAS--NPCQHGATCSDFIGGYRCECVPGYQGVNC 1184

  Fly  1621 E------------------EVIRSLSDVSLTGRRSYL-------AVRWPYLYDGG---DKLGAKR 1657
            |                  :::.........|.|..|       ..|.|:..:||   |::|   
Human  1185 EYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIG--- 1246

  Fly  1658 SQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQ 1722
                   .::.:.:|                                                  
Human  1247 -------GYSCRCLP-------------------------------------------------- 1254

  Fly  1723 LRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGP-------------SNHVTVVRS 1774
                                    ||.....:|.:.|. :|.|             ::::.|.||
Human  1255 ------------------------GFAGERCEGDINEC-LSNPCSSEGSLDCIQLTNDYLCVCRS 1294

  Fly  1775 VRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDV-SKLPHNAIS 1838
                          |..||....:|:              |.|......||...| |.:|...|.
Human  1295 --------------AFTGRHCETFVD--------------VCPQMPCLNGGTCAVASNMPDGFIC 1331

  Fly  1839 GFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDGTACGGDSCESGGHCWLDEKLQPHCICP 1903
            ..|..|         ||.|                |. ::||...|..|..| :.....|.|.||
Human  1332 RCPPGF---------SGAR----------------CQ-SSCGQVKCRKGEQC-VHTASGPRCFCP 1369

  Fly  1904 EYAKGDRCEYSETCKLIPCKNNGRCLRSGR-----CSCPNGWGGFYCEIAMSKPTTP 1955
            ....   ||  ..|...||::.|.|....:     |.|...:.|..||:..:.|:||
Human  1370 SPRD---CE--SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTP 1421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 18/33 (55%)
EGF_CA 220..256 CDD:238011 18/37 (49%)
EGF_CA <270..298 CDD:238011 9/39 (23%)
EGF_CA 301..336 CDD:238011 15/37 (41%)
EGF 342..371 CDD:394967 13/28 (46%)
EGF_CA 378..413 CDD:238011 17/34 (50%)
Laminin_G_2 1096..1244 CDD:460494 21/147 (14%)
EGF_CA 1314..1346 CDD:238011 12/31 (39%)
LamG 1355..1521 CDD:238058 35/171 (20%)
EGF 1549..1578 CDD:394967 11/28 (39%)
EGF_CA 1585..1621 CDD:238011 14/35 (40%)
Laminin_G_2 1723..1856 CDD:460494 24/146 (16%)
LamG 1956..2144 CDD:238058 386/1942 (20%)
NOTCH2NP_077719.2 EGF_CA 182..218 CDD:238011 6/16 (38%)
EGF_CA 260..296 CDD:238011 19/35 (54%)
EGF_CA 298..335 CDD:238011 18/36 (50%)
EGF_CA 415..454 CDD:238011 15/38 (39%)
EGF_CA 456..492 CDD:238011 15/35 (43%)
EGF_CA 495..530 CDD:238011 17/35 (49%)
EGF_CA 532..568 CDD:238011 10/157 (6%)
EGF_CA 570..604 CDD:238011 7/76 (9%)
EGF_CA 608..643 CDD:238011 10/109 (9%)
EGF_CA 645..679 CDD:238011 7/86 (8%)
EGF_CA 682..717 CDD:238011 10/114 (9%)
EGF_CA 757..793 CDD:238011 13/35 (37%)
EGF_CA 795..831 CDD:238011 10/80 (13%)
EGF_CA 873..909 CDD:238011 9/48 (19%)
EGF_CA 911..947 CDD:238011 12/60 (20%)
EGF_CA 949..985 CDD:238011 13/36 (36%)
EGF_CA 987..1022 CDD:238011 11/58 (19%)
EGF_CA 1026..1061 CDD:238011 11/57 (19%)
EGF_CA 1117..1147 CDD:238011 12/29 (41%)
EGF_CA 1151..1185 CDD:238011 14/35 (40%)
EGF_CA 1188..1223 CDD:238011 3/34 (9%)
EGF_CA 1225..1262 CDD:238011 9/120 (8%)
EGF_CA 1264..1302 CDD:238011 9/52 (17%)
EGF_CA <1312..1343 CDD:238011 11/55 (20%)
Notch 1423..1456 CDD:459658
Notch 1463..1497 CDD:459658
Notch 1501..1534 CDD:459658
NOD 1539..1594 CDD:462014
NODP 1618..1673 CDD:462229
JMTM_Notch2 1659..1740 CDD:411986
ANK repeat 1827..1874 CDD:293786
ANKYR <1851..2066 CDD:440430
ANK repeat 1877..1907 CDD:293786
ANK repeat 1943..1974 CDD:293786
ANK repeat 1976..2007 CDD:293786
ANK repeat 2009..2040 CDD:293786
DUF5585 2068..2422 CDD:465521
Blue background indicates that the domain is not in the aligned region.

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