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Protein Alignment eys and NOTCH1

DIOPT Version :10

Sequence 1:	NP_001027571.3	Gene:	eys / 3771890	FlyBaseID:	FBgn0031414	Length:	2176	Species:	Drosophila melanogaster
Sequence 2:	NP_060087.3	Gene:	NOTCH1 / 4851	HGNCID:	7881	Length:	2555	Species:	Homo sapiens

Alignment Length:	1991	Identity:	410/1991 - (20%)
Similarity:	598/1991 - (30%)	Gaps:	697/1991 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 LLLPALILAILVGSSQAGFACLSNP---CVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSS 189
            ||.|.|.||:|...:..|..| |.|   |:.|...:..|.:.:|.|...:.|.:|| :.:.|.|:
Human     4 LLAPLLCLALLPALAARGPRC-SQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPCLST 66

  Fly   190 PCQNGGTC--VD--GVAYYNCTCPEGFSGSNCEENVDE-CMSNPCQNGGLCRDRT-NGYICTCQP 248
            ||:|.|||  ||  |||.|.|:|..||||..|...:|. |::|||:|||.|...| ..|.|.|.|
Human    67 PCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPP 131

  Fly   249 GYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSP--CQN 311
            |:.|..|: ....|.:..   |.:||:|:.... .:.|.||..:||..|::::|||...|  |::
Human   132 GWSGKSCQ-QADPCASNP---CANGGQCLPFEA-SYICHCPPSFHGPTCRQDVNECGQKPGLCRH 191

  Fly   312 GGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPT------CYCVPDYHG 370
            ||.|.:::.:|.|.|...:||.|||...:.|:.:||||...|.     ||      |.|:|.:.|
Human   192 GGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCR-----PTGDVTHECACLPGFTG 251

  Fly   371 EKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQSPP 435
            :.||...|:|. |..|.|||.|:|||:|::|.|||..||..|.     |:..:|.
Human   252 QNCEENIDDCP-GNNCKNGGACVDGVNTYNCRCPPEWTGQYCT-----EDVDECQ---------- 300

  Fly   436 RRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVS 500
                                                              |.|::..:..
Human   301 --------------------------------------------------LMPNACQNGG----- 310

  Fly   501 VEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTT 565
                  |......|.:.:.|...|.           |..|:...:..||:.....|..:.:....
Human   311 ------TCHNTHGGYNCVCVNGWTG-----------EDCSENIDDCASAACFHGATCHDRVASFY 358

  Fly   566 ARPPTSRS-----------SSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFE 619
            ...|..|:           |:...|..:..|.  |:.||...:..|..:|...:.:    |....
Human   359 CECPHGRTGLLCHLNDACISNPCNEGSNCDTN--PVNGKAICTCPSGYTGPACSQD----VDECS 417

  Fly   620 VSGSKSES--------GSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQRV 676
            :..:..|.        ||.|...::....|...|.|:...|....:.:..::.......:.:...
Human   418 LGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGY 482

  Fly   677 TTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFFTE 741
            ..:...::.|                     ..|..|.|.........:....|.||.......:
Human   483 EGVHCEVNTD---------------------ECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQ 526

  Fly   742 YPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTT 806
            |..:...:|                     |.::.:..|..|:|              .:.:.|.
Human   527 YDVDECAST---------------------PCKNGAKCLDGPNT--------------YTCVCTE 556

  Fly   807 GSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEIT-------TGHPLQTEDL 864
            |...||..           ..:...:.|..|:....|...|     .|       |||..:|
Human   557 GYTGTHCE-----------VDIDECDPDPCHYGSCKDGVAT-----FTCLCRPGYTGHHCET--- 602

  Fly   865 IGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAP-------PATPAPVPPATTTPPPSPP 922
             .:.|    .:..|.....|..............||..|       ....:|....|........
Human   603 -NINE----CSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGY 662

  Fly   923 SLATETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYT--TPDG--PPTAS 983
            ..|.| |....::..:.:......|         ..:..|.   ...||.:|  .|:|  .||.
Human   663 ECACE-PGYTGSMCNINIDECAGNP---------CHNGGTC---EDGINGFTCRCPEGYHDPTC- 713

  Fly   984 QTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVD-----CIKLGCYNGGTCVTTSEGSRCV 1043
            .::.:...|:..|.|....|..|......|.....:.|     |....|.|||||...:.|..|.
Human   714 LSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCT 778

  Fly  1044 CRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLA 1108
            ||....||.|:..|   |...|...........|:.|:: .:.:||.       |.||..:::..
Human   779 CREGFSGPNCQTNI---NECASNPCLNQGTCIDDVAGYK-CNCLLPY-------TGATCEVVLAP 832

  Fly  1109 AAQG--TKGGHYMALFLQKGLMQFQFSCGLQTMLLSE-LETPVNT-----------------GHE 1153
            .|..  ..||.     .::......|||...|....: .|..:|.                 |:.
Human   833 CAPSPCRNGGE-----CRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYR 892

  Fly  1154 ITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIG 1218
            ...:|      .|:..|....::|.      :|.
Human   893 CHCQA------GYSGRNCETDIDDC------RPN------------------------------- 914

  Fly  1219 LIIELPPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGS--LACLSSPCRNGAACIKIE 1281
                  |..:|...|..::|         .|.|.|.||..|.|..  ..|.|.||||||.|
Human   915 ------PCHNGGSCTDGINT---------AFCDCLPGFRGTFCEEDINECASDPCRNGANC---- 960

  Fly  1282 TNDLDENGEKAEKWKCKCPTGYMGPTCEISV--CEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHY 1344
            |:.:|       .:.|.||.|:.|..||.:.  |.::.|..|||||....| :.||||.|..|.|
Human   961 TDCVD-------SYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINS-FTCLCPPGFTGSY 1017

  Fly  1345 CEHNLEV--ALPSFSGSV--NGLSSF-----VAYTVP--IPLEYSLELSFKILP--------QTM 1390
            |:|::..  :.|...|..  :|..|:     ..||.|  ..|.:..:.|    |        ||.
Human  1018 CQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSS----PCKNGGKCWQTH 1078

  Fly  1391 SQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKV 1455
            :|.......|.:|.:                                      .|.|.|..|:..
Human  1079 TQYRCECPSGWTGLY--------------------------------------CDVPSVSCEVAA 1105

  Fly  1456 GRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQG------ 1514
            .|.|                       :||..:...||..:...||  |.....:|:.|
Human  1106 QRQG-----------------------VDVARLCQHGGLCVDAGNT--HHCRCQAGYTGSYCEDL 1145

  Fly  1515 --------------CI-----YDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGAC 1560
                          |.     |..:..||...|...|.            ..||..|.||:.|.|
Human  1146 VDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEE------------IDECLSHPCQNGGTC 1198

  Fly  1561 LQHGATFTCICQEGWYGPLCAQPTNPCD------SFNNKCYEDATCVPLVNGYECDCPVGRTGKN 1619
            |....|:.|.|..|..|..|....:.|:      |.:.||:.:.|||..|.||.|.||.|..|:.
Human  1199 LDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGER 1263

  Fly  1620 CEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFV 1684
            ||                            ||
Human  1264 CE----------------------------GD--------------------------------- 1267

  Fly  1685 MKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFV 1749
               :||                                              .|:|..|.:
Human  1268 ---VNE----------------------------------------------CLSNPCDAR---- 1279

  Fly  1750 SLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWH-KIKMAQRGRWLTLWVEGSASSALAPSAEV 1813
                          |..|.|.        .:.::| :.:....||.....:.|....   |...
Human  1280 --------------GTQNCVQ--------RVNDFHCECRAGHTGRRCESVINGCKGK---PCKN- 1318

  Fly  1814 LVEPDSLLYIGGLKDVSKLPHNAISGF----PIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDC 1874
                      ||...|:.   |...||    |..|.|..                         |
Human  1319 ----------GGTCAVAS---NTARGFICKCPAGFEGAT-------------------------C 1345

  Fly  1875 --DGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLI---PCKNNGRCLRSG-- 1932
              |...||...|.:||.| :.....|.|:|.....|..|::..:...:   ||.|.|.|..:.
Human  1346 ENDARTCGSLRCLNGGTC-ISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSES 1409

  Fly  1933 ---RCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRI 1970
               ||.||..:.|..|.|     ...||.|.:...:|||.|
Human  1410 PFYRCLCPAKFNGLLCHI-----LDYSFGGGAGRDIPPPLI 1445

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.