Protein Alignment eys and Egflam

DIOPT Version :10

• Sequence 1: NP_001027571.3
• Gene: eys / 3771890
• FlyBaseID: FBgn0031414
• Length: 2176
• Species: Drosophila melanogaster
• Sequence 2: XP_006232075.1
• Gene: Egflam / 365691
• RGDID: 1306592
• Length: 1013
• Species: Rattus norvegicus
• Alignment Length: 1196
• Identity: 266/1196 - (22%)
• Similarity: 429/1196 - (35%)
• Gaps: 354/1196 - (29%)

  Fly   740 TEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLIT 804
            |||...:...: :|..||.:.   |..|||.|  :||.:....||.|.::|       |..|.:.
  Rat   108 TEYRVSIAAYS-QTGKGRLSF---PRHVTTLS--QDSCLPPEAPHQPHVLV-------VSDSEVA 159

  Fly   805 TTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITT--GHPLQTEDLI-- 865
            .:..|           .|.||:.  |::.       :..||..|...:..|  ...||.:.::
  Rat   160 LSWRP-----------GENEGSA--PIQS-------YSVEFIRPDFDKSWTIIQERLQMDSMVIK 204

  Fly   866 GVQEPAVVTTESPFA--------------PAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTT 916
            |: :|   .|...||              |:.|.       .|:.|....:....|..:   |.|
  Rat   205 GL-DP---DTNYQFAVRAMNAYGFSLRSQPSNTI-------RTLGPGEAGSGRYGPGYI---TDT 255

  Fly   917 PPPSPPSLATETPTLPPTLPPVTLPPVTQ--PPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGP 979
            ........:.:...|..:...|...|.|:  ...:...:..:::....|..||||....||...|
  Rat   256 GVSEDDDASEDELDLDVSFEEVKPLPATKVGNKKSKKTSVSNSEMDSRLAQPTSASLPETTVAVP 320

  Fly   980 PTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSE--GSRC 1042
            ||.:|.|           |.|:|:...|         ..|:.|.:..|.....||....  ||||
  Rat   321 PTPAQRK-----------GKNSVAVMSR---------LFDMSCDETLCSADSFCVNDYAWGGSRC 365

  Fly  1043 VCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIML 1107
            .|...:.|..|...|.|:...|.|.|||:....|:     |..|   ..|.|:.|..|.:||::.
  Rat   366 HCNLGKGGEACSEDIFIQYPQFFGHSYVTFEPLKN-----SYQA---FQITLEFRAEAEDGLLLY 422

  Fly  1108 AAAQGTKGGHYMALFLQKGLMQFQFSCGL-QTMLLSELETPVNTGHEITIRAELDFSRNYTHCNA 1171
            ........|.:|:|.|.:..:.|:|:||. ..:::||.:..:...|.:|:..:        ..|.
  Rat   423 CGESEHGRGDFMSLALIRRSLHFRFNCGTGMAIIISETKIKLGAWHSVTLYRD--------GLNG 479

  Fly  1172 SLLVNDTLAMSG-DQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGC 1235
            .|.:|:...::| .|..:.|:   ...||       |:|||||.| ..|:   ....:..||.||
  Rat   480 LLQLNNGTPVTGQSQGQYSKI---TFRTP-------LYLGGAPSA-YWLV---RATGTNRGFQGC 530

  Fly  1236 LHTLRINGQAREI----FGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWK 1296
            :.:|.:||:..::    .|.||:|..:.||.|
  Rat   531 VQSLAVNGKKIDMRPWPLGKALNGADVGECSS--------------------------------- 562

  Fly  1297 CKCPTGYMGPTCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVN 1361
                          .:|::..|..||||.......|:||||||..|.:||....:.:|.|..|
  Rat   563 --------------GICDEASCINGGTCAAIKADSYICLCPLGFRGRHCEDAFTLTIPQFRES-- 611

  Fly  1362 GLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSG-------YHDEKSDHLAVSFIQG 1419
             |.|:.|  .|.|||....|||     |..:|:   |...||       |.....|.|::....|
  Rat   612 -LRSYAA--TPWPLEPQHYLSF-----TEFEIT---FRPDSGDGVLLYSYDTSSKDFLSIIMAAG 665

  Fly  1420 YIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMD 1484
            ::...::.|:|...:.::..:..     ...::::|.|..:...|.||.:..:.|.:.|..:::.
  Rat   666 HVEFRFDCGSGTGVLRSEDTLTL-----GQWHDLRVSRTAKNGILQVDKQKVVEGMAEGGFTQIK 725

  Fly  1485 VLPILYLGGHEIANFNTLPHDLPLHSG----FQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCG 1545
            ....:::||  :.|::    |:..:||    |.|.|..:.|....:.|....|.||......
  Rat   726 CNTDIFIGG--VPNYD----DVKKNSGILHPFSGSIQKIILNDRTIHVRHDFTSGVNVENAA--- 781

  Fly  1546 TRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECD 1610
                  |.|.  ||...||                                 .:|.|...|||||
  Rat   782 ------HPCV--GAPCAHG---------------------------------GSCRPRKEGYECD 805

  Fly  1611 CPVGRTGKNCEE---------VIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNF 1666
            ||:|..|.||::         :..::......| ||||.      ||..:
  Rat   806 CPLGFEGLNCQKECGNYCLNTITEAIEIPQFIG-RSYLT------YDNPN--------------- 848

  Fly  1667 TKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGL 1731
                                :|..|...||.:                   |:.|  :..::.||
  Rat   849 --------------------ILKRVSGSRSNA-------------------FMRF--KTTAKDGL 872

  Fly  1732 LLYFG--TLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRM---LAIGEWHKIKMAQR 1791
            ||:.|  .:..|.|    |:||.|:.|.:.|..:..|.    |.|:.:   .:.|.||::|..:.
  Rat   873 LLWRGDSPMRPNSD----FISLGLRDGALVFSYNLGSG----VASIMVNGSFSDGRWHRVKAVRD 929

  Fly  1792 GRWLTLWVEG-SASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSG 1855
            |:...:.|:. .|.:..:|.....:..:..||:||:|::: |..|         |..:||||...
  Rat   930 GQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIA-LHTN---------RQYMRGLVGCI 984

  Fly  1856 TRIVLNE-------TNIVESRNIRDC 1874
            :...|:.       .:.|:.:||..|
  Rat   985 SHFTLSTDYHISLVEDAVDGKNINTC 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eys	NP_001027571.3	EGF_CA	184..218	CDD:238011
		EGF_CA	220..256	CDD:238011
		EGF_CA	<270..298	CDD:238011
		EGF_CA	301..336	CDD:238011
		EGF	342..371	CDD:394967
		EGF_CA	378..413	CDD:238011
		Laminin_G_2	1096..1244	CDD:460494	38/149 (26%)
		EGF_CA	1314..1346	CDD:238011	13/31 (42%)
		LamG	1355..1521	CDD:238058	39/176 (22%)
		EGF	1549..1578	CDD:394967	6/28 (21%)
		EGF_CA	1585..1621	CDD:238011	12/35 (34%)
		Laminin_G_2	1723..1856	CDD:460494	36/138 (26%)
		LamG	1956..2144	CDD:238058
Egflam	XP_006232075.1	FN3	36..133	CDD:238020	8/28 (29%)
		FN3	142..236	CDD:238020	24/131 (18%)
		LamG	387..537	CDD:238058	47/179 (26%)
		EGF_CA	556..598	CDD:238011	17/88 (19%)
		LamG	614..761	CDD:238058	36/167 (22%)
		EGF_CA	786..816	CDD:238011	16/62 (26%)
		Laminin_G_2	864..989	CDD:460494	37/144 (26%)