DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eys and EYS

DIOPT Version :9

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:NP_001278938.1 Gene:EYS / 346007 HGNCID:21555 Length:3165 Species:Homo sapiens


Alignment Length:2387 Identity:571/2387 - (23%)
Similarity:902/2387 - (37%) Gaps:571/2387 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 NPCVFGVCIDGLN-----SSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPE 210
            |.|....|:|..|     ..|:|.|..|||||.|:.|.|||.|.||.:.|.|:||:.:|.|.|..
Human   968 NKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKS 1032

  Fly   211 GFSGSNCEENVDECMSNPCQNG-------------------------------------GLCRDR 238
            ||.|::||.|.::|:||||.:|                                     |.|:..
Human  1033 GFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKS 1097

  Fly   239 TNGYICTCQPGYLGSHCELDVAVCETG--TGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEI 301
            .:|:.|.|..||.|::||..:..|...  ....|.:||.|::|||..|.|.|..|:.|:.|:..|
Human  1098 AHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEINI 1162

  Fly   302 NECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPTCYCVP 366
            |||:||||.:|..|.|.:..|.|.|..|::|.:||.| |.|..|.|.:. ||:..|...||.|.|
Human  1163 NECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENE-LECIPNSCVHE-LCMENEPGSTCLCTP 1225

  Fly   367 DYHGEKCEFQYDECQLGPRC---MNGGVCI-------DGVDTFSCSCPPLLTGMLCECLMVGEES 421
            .:.         .|.:|..|   :....|:       |.:.|.:.:.||      .|.|:....|
Human  1226 GFM---------TCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPP------SETLVSSFPS 1275

  Fly   422 LDCNY------TAPATQSPPRRTTTTSTMAP----PTVRPVTPPETTVSPSRASEEVEIIVVTTS 476
            :....      |.|..|.|.:.......:.|    .|:|..||.|:.:        ::.::||..
Human  1276 IKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYL--------LQELIVTRE 1332

  Fly   477 APAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSH------------------------- 516
            ..|:  .|:||.:..|||......:......|....|.||                         
Human  1333 LSAK--HSLLSSADVSSSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIM 1395

  Fly   517 ------------SISVE--QTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGT-TA 566
                        |:..|  ||.|:.|.|   :.....|.|..:.|...:|.......:|..: :|
Human  1396 SSLMSDFIFPTQSLLFENCQTVALSATP---TTSVIRSIPGADIELNRQSLLSRGFLLIAASISA 1457

  Fly   567 RPPTSRSSSSSEE-----------------SPSIFTTLPPLPGKP---------QTSASSESSGE 605
            .|..||.:....|                 |||:   .|..|.|.         .:||....|.:
Human  1458 TPVVSRGAQEDIEEYSADSLISRREHWRLLSPSM---SPIFPAKVIISKQVTILNSSALHRFSTK 1519

  Fly   606 VVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSI------TISVDITSSGSSSSSSESV-- 662
            .....||..:        ...|.::.:|.::..||.|:      ..:..:|...||...|:.|  
Human  1520 AFNPSEYQAI--------TEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLH 1576

  Fly   663 -------EVFTTPAPVF--------VQRVTTIETSISIDYVTPTPLPETTTPRVVP--------- 703
                   |.|...:.:.        .|.:|:..:..|...:||: :..|..|.:.|         
Human  1577 SKQSHFYETFWMNSAILASWYALMGAQTITSGHSFSSATEITPS-VAFTEVPSLFPSKKSAKRTI 1640

  Fly   704 ----------------------------VPRPTFAPE---------------------------- 712
                                        ||..|.:.:                            
Human  1641 LSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIR 1705

  Fly   713 ------PPLDV--------VETTASTHHLWTEVPTTAAPFF----TEYPAEVLITTHR--TSAGR 757
                  .|.:|        :|.:..:|.|:...|:.::..|    ..|| :|.:.|:.  |.|..
Human  1706 QYGITMGPTEVLNQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYP-DVTLKTYSEITHAND 1769

  Fly   758 FTTVQPP--------AGVTTT------------SPTEDSSVELPTPHTPQIV--VTILDSN---- 796
            |....||        :.|||.            |....||:.:..|..|...  :|.|...    
Human  1770 FKNNLPPLTGSVPDFSEVTTNVAFYTVSATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTS 1834

  Fly   797 ------EVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLE----------EDEHHHHHHHDEF 845
                  |:.|| :.....||...|...     ....||..||          .|.....::.|.:
Human  1835 SEWSKWELQPS-VQYQEFPTASRHLPF-----TRSLTLSSLESILAPQRLMISDFSCVRYYGDSY 1893

  Fly   846 TTPQPVEITTGHPLQTED--------LIGVQEPAVVTT---------------------ESPFAP 881
            ...|.|.:...:.:..|.        |:.|::.:.:..                     |:.|..
Human  1894 LEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKS 1958

  Fly   882 AETTV-------VPVVVPATIAPLG---TAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLP 936
            ..|||       ..:::...:.|..   |.....|............|.|.|.:......|....
Human  1959 INTTVRVDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHG 2023

  Fly   937 PVTLPPVTQPPPTIPPTPPSTQSAQTLP-------PPTSAINVY----TTPDG---PPTASQTKP 987
            .:.:|         .|....|...:.:.       .|:.|:..|    ....|   .|||     
Human  2024 KIQMP---------VPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQGFMLSPTA----- 2074

  Fly   988 SVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTC--VTTSEG---SRCVCRFD 1047
            |..::|:..:|.:|:.|....|...|.....||      |:|||||  :..|.|   .:|.|...
Human  2075 SFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDV------CHNGGTCHAIFLSSGIVSFQCDCPLH 2133

  Fly  1048 RQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQG 1112
            ..|..||....:...:|:|:||:.....|.:...|....|.   |.|.::|.:.||.|:.:....
Human  2134 FTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEKEHNRTVT---IYLTIKTNSLNGTILYSNGNN 2195

  Fly  1113 TKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVND 1177
            . |..::.|||.:|....::.||....:|:     |:..:.|...|....:..||....|..|..
Human  2196 C-GKQFLHLFLVEGRPSVKYGCGNSQNILT-----VSANYSINTNAFTPITIRYTTPVGSPGVVC 2254

  Fly  1178 TLAMSGD-QPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRI 1241
            .:.|:.| :|...|......|..:|...: :.||..| |.:.:..:..|..   ||.||:..|::
Human  2255 MIEMTADGKPPVQKKDTEISHASQAYFES-MFLGHIP-ANVQIHKKAGPVY---GFRGCILDLQV 2314

  Fly  1242 NGQAREIFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGP 1306
            |.:...|..:|..|..|..|....|....|||...||       .:|    |...|:||..|.|.
Human  2315 NNKEFFIIDEARHGKNIENCHVPWCAHHLCRNNGTCI-------SDN----ENLFCECPRLYSGK 2368

  Fly  1307 TCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGS-VNGLSSFVAYT 1370
            .|:.:.||:|||..|.|||...|:..:||||.|:.|..|...:.:..|.|||: ..|.:||:||:
Human  2369 LCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYS 2433

  Fly  1371 --VPIPLEYSLELSFKIL-PQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPR 1432
              ..|...|...|.|::. ..:..|.:|:.|.||.|:.....|.|||..:.|.::.::|||:|..
Human  2434 RISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIA 2498

  Fly  1433 RIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIA 1497
            .| ..:|::..|..    :.:.:|:..::.||.||...|.:..:||....::|....|:||:...
Human  2499 SI-RSEPLNLSLGV----HTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEY 2558

  Fly  1498 NFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGV--------RGRGVGQCGTRECHRHAC 1554
            ..:.||:.....:||||||:.:|::    |......||:        .||.||||....|....|
Human  2559 TPDLLPNGADFKNGFQGCIFTLQVR----TEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKC 2619

  Fly  1555 QHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFN---NKCYEDATCVPLVNGYECDCPVGRT 1616
            .:.|.|::.|.:..|.|..||.|..|.:..:.||..:   :.|...|||:.|.:||.|.||:|.|
Human  2620 GNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTT 2684

  Fly  1617 GKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSS 1681
            |..||:.:             .|.|                           .|..|||..    
Human  2685 GIYCEQAL-------------ILIV---------------------------ILEKPKPAE---- 2705

  Fly  1682 HFVMKLLNEVEKQRSFSPVPLMGSK-----SFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNN 1741
                   .:|:|:......|...|.     ||...|..:...|:.|.:||:..|:|.|  ...:.
Human  2706 -------RKVKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFY--AAQHL 2761

  Fly  1742 QDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAI--GEWHKIKMAQRGRWLTLWVEGSAS 1804
            :.:...|:.:||....|:.|.: ..:...::.:::.:.|  ..||.||..:.|....|.::|...
Human  2762 KAQSGDFLCISLVNSSVQLRYN-LGDRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINV 2825

  Fly  1805 SALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESR 1869
            :..|.:....::.::..||||:..::.:...||...|:.|:||:|.::::...:.|.|.......
Human  2826 TEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAKGGS 2890

  Fly  1870 NIRDCDGTACGGDSCESGGHCWLDEKLQPHCIC-PEYAKGDRCEYSETCKLIPCKNNGRCLR--- 1930
            |:.||||||||.::|.:||.|.::.... .|.| |::| |:.|..|.:|....|.:...|:.   
Human  2891 NVGDCDGTACGYNTCRNGGECTVNGTTF-SCRCLPDWA-GNTCNQSVSCLNNLCLHQSLCIPDQS 2953

  Fly  1931 -SGRCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKDKRRGPSLYVRPREAIQVSLN 1994
             |..|.|..||.|.|||...|. :|..|.||||:           |...|:..:|..:...:|||
Human  2954 FSYSCLCTLGWVGRYCENKTSF-STAKFMGNSYI-----------KYIDPNYRMRNLQFTTISLN 3006

  Fly  1995 FSTIEPDGLLLW---SEHERSKFLGLGLEAGHLKLASNLLGSTNDTVRAPAS---GFIADGAWHW 2053
            |||.:.:||::|   :::|.:.||.:||....||:|.||    .:.:..|.|   |......||.
Human  3007 FSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNL----GERISVPMSYNNGTFCCNKWHH 3067

  Fly  2054 TSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYLGGFP 2118
            ..|:.:::.::..::..:|.:|.:          .|.....          .::|:.:.|||||.
Human  3068 VVVIQNQTLIKAYINNSLILSEDI----------DPHKNFV----------ALNYDGICYLGGFE 3112

  Fly  2119 NSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAI----ISDFSTYQGE 2161
            ....|:..|:..|...|.|.::|:.|..||..|    :..::.|.|:
Human  3113 YGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIELIKLEGYNVYDGD 3159

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 16/33 (48%)
EGF_CA 220..256 CDD:238011 15/72 (21%)
EGF_CA <270..298 CDD:238011 12/27 (44%)
EGF_CA 301..336 CDD:238011 16/34 (47%)
EGF 342..371 CDD:278437 10/28 (36%)
EGF_CA 378..413 CDD:238011 8/44 (18%)
Laminin_G_2 1096..1244 CDD:280389 36/148 (24%)
EGF_CA 1314..1346 CDD:238011 15/31 (48%)
LamG 1355..1521 CDD:238058 50/169 (30%)
EGF 1549..1578 CDD:278437 9/28 (32%)
EGF_CA 1585..1621 CDD:238011 15/38 (39%)
Laminin_G_2 1723..1856 CDD:280389 30/134 (22%)
LamG 1956..2144 CDD:238058 48/193 (25%)
EYSNP_001278938.1 Plasmod_Pvs28 195..>283 CDD:283826
EGF_CA 681..731 CDD:238011
EGF_CA 733..769 CDD:238011
EGF_CA 773..806 CDD:238011
EGF_CA 810..846 CDD:238011
EGF_CA 890..926 CDD:238011
EGF_CA 929..964 CDD:238011
EGF_CA 966..1002 CDD:238011 13/33 (39%)
EGF_CA 1004..1040 CDD:238011 17/35 (49%)
EGF_CA 1080..1115 CDD:238011 8/34 (24%)
EGF_CA 1118..1159 CDD:238011 13/40 (33%)
EGF_CA 1161..1197 CDD:238011 16/35 (46%)
LamG 1886..2044 CDD:238058 21/166 (13%)
LamG 2149..2315 CDD:238058 44/179 (25%)
Laminin_G_2 2461..2582 CDD:280389 37/125 (30%)
EGF_CA 2657..2689 CDD:238011 13/31 (42%)
LamG 2740..2877 CDD:214598 32/139 (23%)
Laminin_G_2 3007..3138 CDD:280389 37/154 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I9952
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 549 1.000 Inparanoid score I1150
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D115967at2759
OrthoFinder 1 1.000 - - FOG0009101
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_111086
Panther 1 1.100 - - O PTHR24033
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R17395
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
99.000

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