DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eys and uif

DIOPT Version :10

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster


Alignment Length:1559 Identity:326/1559 - (20%)
Similarity:504/1559 - (32%) Gaps:547/1559 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 CLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGF 212
            |||.||..|.|:|.| ..:.|.|..|:||..|..|.|:|.:.||.|.|||||.|..|:|.|..|:
  Fly  2220 CLSEPCKHGTCVDRL-FDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGY 2283

  Fly   213 SGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECI 277
            :|.||:..:|:|.|||||:|..|.|:.:|:.|.|:|||:|..||.::              .||:
  Fly  2284 TGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEI--------------DECL 2334

  Fly   278 EGP----GLE--------FTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGY 330
            ..|    |.|        |.|.|..|:.|.:|..:|::|.:.||.|.|:|.|::..:.|.|..|:
  Fly  2335 SDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPGW 2399

  Fly   331 TGINCEEEILIC-ADNPCQNNALC--LMEE----------------------GVP---------- 360
            :|:.||:::..| |..||||:|.|  |.::                      |.|          
  Fly  2400 SGMRCEQQVTTCGAQAPCQNDASCIDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDF 2464

  Fly   361 ----TCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEES 421
                .|.|..||.|..|:::||.|: ...|.||..|:|....:||.|||..||..||     ::.
  Fly  2465 GSGLNCSCPADYSGIGCQYEYDACE-EHVCQNGATCVDNGAGYSCQCPPGFTGRNCE-----QDI 2523

  Fly   422 LDC--NYTAPATQ---------------------------------SPPRRTTTTSTMAPPT--- 448
            :||  |...|...                                 |.|.|:|....:..||   
  Fly  2524 VDCKDNSCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTGEA 2588

  Fly   449 ---------------VRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSE-- 496
                           .|.:......|..:|.:::..:::...|:..:|......|.:..|..|  
  Fly  2589 NSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSSGVQVSLFEDQPDAFLSFGEYT 2653

  Fly   497 --------------EGVSVEIKTPT----VAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPH 543
                          :|:|.:::..|    .:..|.|:.........||...|:|..    .|...
  Fly  2654 SVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLPGYLWAVLGLPQPYG----LSNEL 2714

  Fly   544 PESESASES-----------------------ETETEEEIIPGTTARPPTSRSSSSSEES--PSI 583
            ..|:|..:.                       :..:|..:.||..........:|...|.  ||:
  Fly  2715 AYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILNWAGYEVTSGGVERNVPSL 2779

  Fly   584 ---------FTTL----------PPL----PGKPQTSASSESSGEVVTSEEYTTVPHF------- 618
                     :|..          ||:    ||.....|.:.|:  ||:.:|    |||       
  Fly  2780 CGQRKCPVGYTGANCQQLVVDKEPPVVEHCPGDLWVIAKNGSA--VVSWDE----PHFSDNIGVT 2838

  Fly   619 ---EVSGSKSES----GSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQ-- 674
               |.:|.:|.:    |:.::|.:...||            |:::|.|..|.:.|...|....  
  Fly  2839 KIYERNGHRSGTTLLWGTYDITYIASDAA------------GNTASCSFKVSLLTDFCPALADPV 2891

  Fly   675 ---------------RVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTAST 724
                           :|..|..:..:.:  ..|:||..|.......|||..|..||  |..:.| 
  Fly  2892 GGSQVCKDWGAGGQFKVCEIACNAGLRF--SEPVPEFYTCGAEGFWRPTREPSMPL--VYPSCS- 2951

  Fly   725 HHLWTEVPTTAAPFFTE----YPAEVLITTHRTSAGRFTTVQPPA---------------GVTTT 770
                   |:..|.....    :|::||.    ..||:....|...               .:..|
  Fly  2952 -------PSKPAQRVFRIKMLFPSDVLC----NKAGQAVLRQKVTNSVNGLNRDWNFCSYAIEGT 3005

  Fly   771 SPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDE 835
            ...:|..:::...|                    ..|:      .::....:|:...:..:|.:.
  Fly  3006 RECKDIQIDVKCDH--------------------YRGT------QNNRVRRQAKDGGVYVMEAEL 3044

  Fly   836 HHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPA--VVTTESPFAPAETTVVPVVVPATIAPL 898
            ...:...|:.|       .||..       |.|:..  ..|.|..|                   
  Fly  3045 PVVNDDDDDLT-------LTGRQ-------GRQQTGGDTYTLEIAF------------------- 3076

  Fly   899 GTAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLP----PVTQPPPTIPPTPPSTQS 959
                 ||...||...:|          .|..|:...|..:.|.    .|.:..|...|.|.|.:.
  Fly  3077 -----PAANDPVVHTST----------GERSTVKQLLEKLILEDDQFAVQEILPNTVPDPASLEL 3126

  Fly   960 AQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIK 1024
            ......|..  .|...||..|.|..|   ..:|:.:        |....|.|..:.:||.:.|.|
  Fly  3127 GSEYACPVG--QVVMIPDCVPCAIGT---FYDSANK--------TCIACSRGTYQSEAGQLQCSK 3178

  Fly  1025 LGCYNGGTCVTTSEGSRCV--CR--------FDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIG 1079
            .....|...||...|:|..  |:        ||.:..||.              ...|..|:...
  Fly  3179 CPVIAGRPGVTAGPGARSAADCKERCPAGKYFDAETGLCR--------------SCGHGFYQPNE 3229

  Fly  1080 GHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGL-QTMLLSE 1143
            |..|.:.                                               ||| ||...:|
  Fly  3230 GSFSCEL-----------------------------------------------CGLGQTTRSTE 3247

  Fly  1144 LETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTW----LKLLPPRLHT------ 1198
            ..:......|.:...:|........|     ...|..:.|.||:.    |....|::..      
  Fly  3248 ATSRKECRDECSSGQQLGADGRCEPC-----PRGTYRLQGVQPSCAACPLGRTTPKVGASSVEEC 3307

  Fly  1199 --PEAILNTWLHLGGAPQAPIGLIIELPPA--QSGSGFTGCL-----HTLRINGQAREIFGDALD 1254
              |.....|:|:      |...:.||....  ||.|..|.||     |:.:|.|...:       
  Fly  3308 TLPVCSAGTYLN------ATQNMCIECRKGYYQSESQQTSCLQCPPNHSTKITGATSK------- 3359

  Fly  1255 GFGITECGSLACLSSPCRN----------GAACIKI-ETNDLDENGEKAEKWKCKCPTGY--MGP 1306
                :||      ::||.:          .|.||.: ||:|          :||:|..|:  .|.
  Fly  3360 ----SEC------TNPCEHIAEGKPHCDVNAYCIMVPETSD----------FKCECKPGFNGTGM 3404

  Fly  1307 TCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTV 1371
            .| ..|| |..|:..|.||:.......|.|.....|.:|....|.|.  .:|.:.|...|:...|
  Fly  3405 AC-TDVC-DGFCENSGACVKDLKGTPSCRCVGSFTGPHCAERSEFAY--IAGGIAGAVIFIIIIV 3465

  Fly  1372 PIPLEYSL---------ELSFKILPQTMSQISLLAFFG----------------QSGYHDEKSD 1410
            .:.....:         ::....:.||.||::.  ::|                .:.|:|::.|
  Fly  3466 LLIWMICVRSTKRRDPKKMLTPAIDQTGSQVNF--YYGAHTPYAESIAPSHHSTYAHYYDDEED 3527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 17/33 (52%)
EGF_CA 220..256 CDD:238011 17/35 (49%)
EGF_CA <270..298 CDD:238011 10/39 (26%)
EGF_CA 301..336 CDD:238011 12/34 (35%)
EGF 342..371 CDD:394967 15/67 (22%)
EGF_CA 378..413 CDD:238011 14/34 (41%)
Laminin_G_2 1096..1244 CDD:460494 29/167 (17%)
EGF_CA 1314..1346 CDD:238011 8/31 (26%)
LamG 1355..1521 CDD:238058 12/81 (15%)
EGF 1549..1578 CDD:394967
EGF_CA 1585..1621 CDD:238011
Laminin_G_2 1723..1856 CDD:460494
LamG 1956..2144 CDD:238058
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
PHA02639 697..>834 CDD:165022
FA58C 833..976 CDD:330301
FXa_inhibition 988..>1016 CDD:464251
CCP 1051..1106 CDD:153056
FA58C 1303..1443 CDD:330301
HYR 1463..1547 CDD:460572
HYR 1548..1631 CDD:460572
Ephrin_rec_like 1862..1909 CDD:429604
Ephrin_rec_like 1916..1966 CDD:429604
Ephrin_rec_like 1973..2020 CDD:429604
EGF 2025..2055 CDD:394967
EGF_CA 2059..2095 CDD:238011
EGF_CA 2138..2176 CDD:238011
EGF_CA 2178..2214 CDD:238011
EGF_CA 2253..2289 CDD:238011 18/35 (51%)
EGF_CA 2292..2327 CDD:238011 17/34 (50%)
EGF_CA 2369..2405 CDD:238011 12/35 (34%)
EGF_CA 2411..2444 CDD:238011 9/32 (28%)
EGF_CA 2486..2520 CDD:238011 14/34 (41%)
EGF_CA 2522..2557 CDD:238011 4/34 (12%)
LamG 2590..2735 CDD:473984 20/148 (14%)
HYR 2799..2877 CDD:460572 22/95 (23%)
Ephrin_rec_like 3149..3200 CDD:429604 14/61 (23%)
Ephrin_rec_like 3207..3254 CDD:429604 14/107 (13%)
Ephrin_rec_like 3268..3307 CDD:429604 7/43 (16%)
Ephrin_rec_like 3315..3362 CDD:429604 14/63 (22%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.