DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eys and Agrn

DIOPT Version :9

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:XP_017448655.1 Gene:Agrn / 25592 RGDID:2067 Length:2066 Species:Rattus norvegicus


Alignment Length:1969 Identity:440/1969 - (22%)
Similarity:668/1969 - (33%) Gaps:617/1969 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 CLSNPCVFGVCIDGLNSSYSCYC-------------IDGYT-GIQCQTNWDECW---------SS 189
            |....|.||......|....|.|             .||.| |..|:.....|.         ..
  Rat   470 CHGVQCAFGAVCTVKNGKAECECQRVCSGIYDPVCGSDGVTYGSVCELESMACTLGREIQVARRG 534

  Fly   190 PCQNGGTCVDG----VAYYNCTCPE----------GFSG----SNCEENVDEC---------MSN 227
            ||...|.|..|    |....|.||.          |..|    |.||.:|..|         .:.
  Rat   535 PCDPCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAG 599

  Fly   228 PCQNGG--LCRDRTNGYICT--------CQ---PG---------YLGSHCELDVAVCETGTGARC 270
            .||..|  :|   |.|.:|:        |:   ||         || |.|||..|.|:.......
  Rat   600 HCQTCGEKVC---TFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYL-SACELREAACQQQVQIEE 660

  Fly   271 QHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSPC-QNGG--------------------- 313
            .|.|.|       ...:|.:|..|   ..|.:||....| |.||                     
  Rat   661 AHAGPC-------EPAECGSGGSG---SGEDDECEQELCRQRGGIWDEDSEDGPCVCDFSCQSVP 715

  Fly   314 ---VCVDKLAAYACACPMGYTGINCEEEILI---------------------CADNP---CQNNA 351
               ||......|...|.:.......::|:.:                     ||..|   ||:|.
  Rat   716 RSPVCGSDGVTYGTECDLKKARCESQQELYVAAQGACRGPTLAPLLPVAFPHCAQTPYGCCQDNF 780

  Fly   352 LCLMEEGV----PTCYCVPDYHGE---KCEFQYDECQLGP--------RCMNG-----GVCIDGV 396
            ......|:    .||:|.|  ||.   .|:....:|...|        ||..|     |:..||.
  Rat   781 TAAQGVGLAGCPSTCHCNP--HGSYSGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGH 843

  Fly   397 DTFS-CSCPP---------LLTGMLCECL--MVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTV 449
            ...: |||.|         .:|| ||.|.  :.|.:...|                         
  Rat   844 SGCTPCSCDPRGAVRDDCEQMTG-LCSCRPGVAGPKCGQC------------------------- 882

  Fly   450 RPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSV-LSPSSSSSSSEEGVSVEIKTPTVAPPES 513
                 |:..|......|         :.|...||.| :.....:|..|:....:...||:..||:
  Rat   883 -----PDGQVLGHLGCE---------ADPMTPVTCVEIHCEFGASCVEKAGFAQCICPTLTCPEA 933

  Fly   514 GSHSISVEQTTAVPAQPEPESEQEPESKP---HPESESASESETETEEEIIPGTTARPPTSRSSS 575
            .|        |.|..........|.:.|.   ....:.:::|....:|.:.||.:   |||.|.:
  Rat   934 NS--------TKVCGSDGVTYGNECQLKAIACRQRLDISTQSLGPCQESVTPGAS---PTSASMT 987

  Fly   576 S-----SEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTT----VPHFEVSGSKSESGSEE 631
            :     |:..|....:||..||.              |:.::.|    .||..||..:|.:.  .
  Rat   988 TPRHILSKTLPFPHNSLPLSPGS--------------TTHDWPTPLPISPHTTVSIPRSTAW--P 1036

  Fly   632 VTTVRPTAAPSITISVDITS--------SGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYV 688
            |.||.||||.|     |:||        |||::.|.:.                    .:|.|  
  Rat  1037 VLTVPPTAAAS-----DVTSLATSIFSESGSANGSGDE--------------------ELSGD-- 1074

  Fly   689 TPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFFTEYPAEVLITTHRT 753
                                                     |..:.......|.|...::.||..
  Rat  1075 -----------------------------------------EEASGGGSGGLEPPVGSIVVTHGP 1098

  Fly   754 SAGRFTTVQPPAGVTT--TSPTEDS-SVELPTPHTPQIVVTI--LDSNEVI--PSLITTTGSPTT 811
            ...|.:....|.|..:  .:|:.|| ....|.....|.|:.:  ::..|:.  |.:.        
  Rat  1099 PIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMA-------- 1155

  Fly   812 HHHHHHHPHHEAEGTTLQPLE---EDEHHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQ-EPAV 872
                  .|..|..|.|.:.:|   :|...:.....:|.:.:..|:..|..::.  ::.|. :|..
  Rat  1156 ------DPKSELFGETARSIESTLDDLFRNSDVKKDFWSVRLRELGPGKLVRA--IVDVHFDPTT 1212

  Fly   873 VTTESPFAPAETTVVPVVVPATIA---PLG---------------TAAPPATPAPVPPATTTPPP 919
            ....|....|....:.|..|..:|   ||.               |.|...|.|           
  Rat  1213 AFQASDVGQALLRQIQVSRPWALAVRRPLQEHVRFLDFDWFPTFFTGAATGTTA----------- 1266

  Fly   920 SPPSLATETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQ 984
               ::||...|....||..::.|...|..|..|...:|....|..|||:|.|:    |.|.|...
  Rat  1267 ---AMATARATTVSRLPASSVTPRVYPSHTSRPVGRTTAPPTTRRPPTTATNM----DRPRTPGH 1324

  Fly   985 TKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTC--VTTSEGSRCVCRFD 1047
            .:||.:                               |....|.:||||  ..:.:|..|.|...
  Rat  1325 QQPSKS-------------------------------CDSQPCLHGGTCQDQDSGKGFTCSCTAG 1358

  Fly  1048 RQGPLCE------LPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIM 1106
            |.|.:||      :|      ||.|.|:::         ..:|.|...:.:.|:.|...|.||::
  Rat  1359 RGGSVCEKVQPPSMP------AFKGHSFLA---------FPTLRAYHTLRLALEFRALETEGLLL 1408

  Fly  1107 LAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTG--HEITIRAELDFSRNYTHC 1169
            ...  ..:|..::||.|..|.:||:|..|....:|:.| .||..|  |      .|:.||::.  
  Rat  1409 YNG--NARGKDFLALALLDGRVQFRFDTGSGPAVLTSL-VPVEPGRWH------RLELSRHWR-- 1462

  Fly  1170 NASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTG 1234
            ..:|.|:....:.|:.|:         .|....|:|.|::||.|:..:.::::  ....|.|..|
  Rat  1463 QGTLSVDGETPVVGESPS---------GTDGLNLDTNLYVGGIPEEQVAMVLD--RTSVGVGLKG 1516

  Fly  1235 CLHTLRINGQAREIFGD----ALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKW 1295
            |:..|.||.|..|: .|    |:...|:.|||...||.:||..||.|..:|          |..:
  Rat  1517 CIRMLDINNQQLEL-SDWQRAAVQSSGVGECGDHPCLPNPCHGGALCQALE----------AGMF 1570

  Fly  1296 KCKCPTGYMGPTC--EISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVA-----L 1353
            .|:||.|..||||  |.|.|:.|||.....|......|..|.||||:.|.:|:..||.|     |
  Rat  1571 LCQCPPGRFGPTCADEKSPCQPNPCHGAAPCRVLSSGGAKCECPLGRSGTFCQTVLETAGSRPFL 1635

  Fly  1354 PSFSG----SVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAV 1414
            ..|:|    .:.||.:|..   .:..:.:||:.|  |.:..|  .||.:.||.  .|.|.|.:::
  Rat  1636 ADFNGFSYLELKGLHTFER---DLGEKMALEMVF--LARGPS--GLLLYNGQK--TDGKGDFVSL 1691

  Fly  1415 SFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGS 1479
            :....::...::||.|...|.:::||     |......:.:.|.||:..|.|.....:.|.||.|
  Rat  1692 ALHNRHLEFCYDLGKGAAVIRSKEPI-----ALGTWVRVFLERNGRKGALQVGDGPRVLGESPKS 1751

  Fly  1480 ----GSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRG 1540
                .:.:::...||:||  ..:|:.|.....:.|||.|.|..|.|:..|:.......|.|.   
  Rat  1752 RKVPHTMLNLKEPLYIGG--APDFSKLARGAAVSSGFNGVIQLVSLRGHQLLTQEHVLRAVD--- 1811

  Fly  1541 VGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPC-DSFNNKCYEDATCVPLV 1604
                                               ..|..   .:|| .:..|.|....:|||..
  Rat  1812 -----------------------------------VSPFA---DHPCTQALGNPCLNGGSCVPRE 1838

  Fly  1605 NGYECDCPVGRTGKNCEE--VIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFT 1667
            ..|||.||.|.:|.:||:  |.:|:.|:....            :||              |.:.
  Rat  1839 ATYECLCPGGFSGLHCEKGLVEKSVGDLETLA------------FDG--------------RTYI 1877

  Fly  1668 KKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLL 1732
            :.|         ::....:|.||:....:.....|...|:.:.:|      .|..||..:.:||:
  Rat  1878 EYL---------NAVIESELTNEIPAPETLDSRALFSEKALQSNH------FELSLRTEATQGLV 1927

  Fly  1733 LYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTL 1797
            |:.|......|    :::|::..|.::......|..| |:||...:....|.:|:..:..|..:|
  Rat  1928 LWIGKAAERAD----YMALAIVDGHLQLSYDLGSQPV-VLRSTVKVNTNRWLRIRAHREHREGSL 1987

  Fly  1798 WVEGSAS-SALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIP------FRGCVRGLVVSG 1855
            .|...|. :..:|.....::.|..|::|||:   |||    .|..:|      |.||:|.:||..
  Rat  1988 QVGNEAPVTGSSPLGATQLDTDGALWLGGLQ---KLP----VGQALPKAYGTGFVGCLRDVVVGH 2045

  Fly  1856 TRIVLNETNIVESRNIRDC 1874
            .::.|.| :.|....:|.|
  Rat  2046 RQLHLLE-DAVTKPELRPC 2063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 13/60 (22%)
EGF_CA 220..256 CDD:238011 15/66 (23%)
EGF_CA <270..298 CDD:238011 6/27 (22%)
EGF_CA 301..336 CDD:238011 10/59 (17%)
EGF 342..371 CDD:278437 12/35 (34%)
EGF_CA 378..413 CDD:238011 15/57 (26%)
Laminin_G_2 1096..1244 CDD:280389 40/149 (27%)
EGF_CA 1314..1346 CDD:238011 11/31 (35%)
LamG 1355..1521 CDD:238058 45/173 (26%)
EGF 1549..1578 CDD:278437 0/28 (0%)
EGF_CA 1585..1621 CDD:238011 14/36 (39%)
Laminin_G_2 1723..1856 CDD:280389 37/139 (27%)
LamG 1956..2144 CDD:238058
AgrnXP_017448655.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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