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Protein Alignment eys and Notch1

DIOPT Version :10

Sequence 1:	NP_001027571.3	Gene:	eys / 3771890	FlyBaseID:	FBgn0031414	Length:	2176	Species:	Drosophila melanogaster
Sequence 2:	NP_001099191.1	Gene:	Notch1 / 25496	RGDID:	3187	Length:	2531	Species:	Rattus norvegicus

Alignment Length:	1998	Identity:	406/1998 - (20%)
Similarity:	610/1998 - (30%)	Gaps:	711/1998 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 LLLPALILAILVGSSQAGFACLSNPCVFGVCIDG-----LNSSYSCYCIDGYTGIQCQTNWDECW 187
            ||.|.|.|.:|...:..|..| |.|.  |.|::|     .|.:.:|.|...:.|.:|| :...|.
  Rat     4 LLAPLLCLTLLPALAARGLRC-SQPS--GTCLNGGRCEVANGTEACVCSGAFVGQRCQ-DPSPCL 64

  Fly   188 SSPCQNGGTC--VD--GVAYYNCTCPEGFSGSNC-EENVDECMSNPCQNGGLCRDRT-NGYICTC 246
            |:||:|.|||  ||  |:..|.|:||.||||..| ....:.|::|||:|||.|...| ..|.|.|
  Rat    65 STPCKNAGTCYVVDHGGIVDYACSCPLGFSGPLCLTPLANACLANPCRNGGTCDLLTLTEYKCRC 129

  Fly   247 QPGYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSP--C 309
            .||:.|..|: ....|.:..   |.:||:|:.... .:.|.||.|:||..|::::|||:.:|  |
  Rat   130 PPGWSGKSCQ-QADPCASNP---CANGGQCLPFES-SYICGCPPGFHGPTCRQDVNECSQNPGLC 189

  Fly   310 QNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPT------CYCVPDY 368
            ::||.|.:::.:|.|||...:||.:||...:.|:.:||||...|.     ||      |.|:|.:
  Rat   190 RHGGTCHNEIGSYRCACRATHTGPHCELPYVPCSPSPCQNGGTCR-----PTGDTTHECACLPGF 249

  Fly   369 HGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQS 433
            .|:.||...|:|. |..|.|||.|:|||:|::|.|||..||..|.     |:..:|.
  Rat   250 AGQNCEENVDDCP-GNNCKNGGACVDGVNTYNCRCPPEWTGQYCT-----EDVDECQ-------- 300

  Fly   434 PPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEG 498
                                                                |.|::..:..
  Rat   301 ----------------------------------------------------LMPNACQNGG--- 310

  Fly   499 VSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPG 563
                    |......|.:.:.|...|.           |..|:...:..||:..:..|..:.:..
  Rat   311 --------TCHNSHGGYNCVCVNGWTG-----------EDCSENIDDCASAACFQGATCHDRVAS 356

  Fly   564 TTARPPTSRS-----------SSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPH 617
            .....|..|:           |:...|..:..|.  |:.||...:..|..:|...:.:    |..
  Rat   357 FYCECPHGRTGLLCHLNDACISNPCNEGSNCDTN--PVNGKAICTCPSGYTGPACSQD----VDE 415

  Fly   618 FEVSGSKSES--------GSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQ 674
            ..:..:..|.        ||.|...::....|...|.|:...|....:.:..::.......:.:.
  Rat   416 CALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMP 480

  Fly   675 RVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFF 739
            ....:...|:.|                     ..|..|.|.........:....:.|...:...
  Rat   481 GYEGVYCEINTD---------------------ECASSPCLHNGRCVDKINEFLCQCPKGFSGHL 524

  Fly   740 TEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVT--------ILDSN 796
            .:|..:...:|                     |.::.:..|..|:|...|.|        .:|.:
  Rat   525 CQYDVDECAST---------------------PCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDID 568

  Fly   797 EVIP------------SLITTTGSPTTHHHH--------HHHP-HHEAEGTTLQPLEEDEHHHHH 840
            |..|            :..|....|....||        |..| .|   |.|.|
  Rat   569 ECDPDPCHYGLCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRH---GGTCQ----------- 619

  Fly   841 HHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGT----- 900
            ..|.:.....::.|||...:    |.:.:.|....:|                     ||
  Rat   620 DRDNYYLCLCLKGTTGPNCE----INLDDCASNPCDS---------------------GTCLDKI 659

  Fly   901 -----AAPPATPAPVPPATTTPPPSPP---------SLATETPTLPPTL-PPVTLPPVTQPPPTI 950
                 |..|.....:...........|         .:|..|...|... .|..|..|.:
  Rat   660 DGYECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNE----- 719

  Fly   951 PPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVT----ESSEEVEG-------TNTVST 1004
            ..:.|....|     ....:|.|.. |..|..|.|...:.    ||:..|.|       :..|.|
  Rat   720 CNSNPCIHGA-----CRDGLNGYKC-DCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCT 778

  Fly  1005 GGRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCEL---PIIIRNAAFSG 1066
            ...|..| |..:....:|....|.|.|||:....|.:|.|.....|..||:   |........||
  Rat   779 CREGFSG-PNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSG 842

  Fly  1067 DSYVSHRIYKDIGGHESLDAVLP---------MHIQLKVRTRATNGLIMLAAAQGTKGGHYMALF 1122
                   :.|:...:||...|.|         :.|...|::...:|    |:.|.|.|
  Rat   843 -------VCKESEDYESFSCVCPTGWQGQTCEIDINECVKSPCRHG----ASCQNTNG------- 889

  Fly  1123 LQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPT 1187
                    .:.|..|.                          .||..|....::|.      :|.
  Rat   890 --------SYRCLCQA--------------------------GYTGRNCESDIDDC------RPN 914

  Fly  1188 WLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDA 1252
                                                 |..:|...|..::.         .|.|.
  Rat   915 -------------------------------------PCHNGGSCTDGVNA---------AFCDC 933

  Fly  1253 LDGF-------GITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEI 1310
            |.||       .|.||.     |:||:|||.|    |:.:|       .:.|.||||:.|..||.
  Rat   934 LPGFQGAFCEEDINECA-----SNPCQNGANC----TDCVD-------SYTCTCPTGFNGIHCEN 982

  Fly  1311 SV--CEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEV--ALPSFSGSVNGLSSFVAYTV 1371
            :.  |.::.|..|||||....| :.||||.|..|.||::::..  :.|...|. ....|:..|..
  Rat   983 NTPDCTESSCFNGGTCVDGINS-FTCLCPPGFTGSYCQYDVNECDSRPCLHGG-TCQDSYGTYKC 1045

  Fly  1372 PIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFT 1436
            ..|                                           |||..|.           .
  Rat  1046 TCP-------------------------------------------QGYTGLN-----------C 1056

  Fly  1437 QKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNT 1501
            |..:.:...||        .:.|.:.| ..:.:::...||..:|...|||.:
  Rat  1057 QNLVRWCDSAP--------CKNGGKCW-QTNTQYHCECRSGWTGFNCDVLSV------------- 1099

  Fly  1502 LPHDLPLHSGFQGCIYDVQLKAGQVTVPLQ--------ETRGVRGRGVGQCGT------RECHRH 1552
                        .|....|.:...||:..|        |.:.......|..|:      .||..:
  Rat  1100 ------------SCEVAAQKRGIDVTLLCQHGGLCVDEEDKHYCHCQAGYTGSYCEDEVDECSPN 1152

  Fly  1553 ACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTG 1617
            .||:...|..:...|:|.|..|::|..|::..|.|  .:..|....||:.|.|.|:|.||.|..|
  Rat  1153 PCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINEC--LSQPCQNGGTCIDLTNTYKCSCPRGTQG 1215

  Fly  1618 KNCEEVIRSLSDVSLTGRRSYL--AVRWPYLYDGG---DKLGAKRSQMVSYRNFTKKLMPPKPIT 1677
            .:||        :::......|  |.|.|..::.|   |::|....           ..||
  Rat  1216 VHCE--------INVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTC-----------TCPP---- 1257

  Fly  1678 TPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQ 1742

  Rat  1258 ----------------------------------------------------------------- 1257

  Fly  1743 DKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWH-KIKMAQRGRWLTLWVEGSASSA 1806
                |||....:|.|.|. :|.|.:.......|:  .:.::| :.:....||.....:.|....
  Rat  1258 ----GFVGERCEGDVNEC-LSNPCDPRGTQNCVQ--RVNDFHCECRAGHTGRRCESVINGCRGK- 1314

  Fly  1807 LAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGF----PIPFRGCVRGLVVSGTRIVLNETNIVE 1867
              |...           ||   |..:..|...||    |..|.|..
  Rat  1315 --PCRN-----------GG---VCAVASNTARGFICRCPAGFEGAT------------------- 1344

  Fly  1868 SRNIRDC--DGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLI---PCKNNGR 1927
                  |  |...||...|.:||.| :.....|.|:|.....|..|::..:...:   ||.|.|.
  Rat  1345 ------CENDARTCGSLRCLNGGTC-ISGPRSPTCLCLGSFTGPECQFPASSPCVGSNPCYNQGT 1402

  Fly  1928 CLRSG-----RCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRI 1970
            |..:.     ||.||..:.|..|.|     ...||.|.:...:|||:|
  Rat  1403 CEPTSESPFYRCLCPAKFNGLLCHI-----LDYSFTGGAGRDIPPPQI 1445

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.