Protein Alignment eys and Y70G10A.2

DIOPT Version :9

• Sequence 1: NP_001027571.3
• Gene: eys / 3771890
• FlyBaseID: FBgn0031414
• Length: 2176
• Species: Drosophila melanogaster
• Sequence 2: NP_499266.2
• Gene: Y70G10A.2 / 190572
• WormBaseID: WBGene00013498
• Length: 1489
• Species: Caenorhabditis elegans
• Alignment Length: 1121
• Identity: 248/1121 - (22%)
• Similarity: 372/1121 - (33%)
• Gaps: 312/1121 - (27%)

  Fly   427 TAPATQSPPRRTTTTSTMAPPTVRPV---TPPETTV---------------------SPSRASEE 467
            |...|.|.....|:|||..|.|..|:   .||..||                     :||..|:.
 Worm    83 TKETTSSSSTLATSTSTEPPTTTFPIWENIPPGVTVEIAGVTIYSCPDYDTTTVSTSTPSSTSQS 147

  Fly   468 VEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEI-KTPTVAPPE-------SGS--------- 515
            ......||:......|:..|.|||:|.:....|... .|||.:..:       |||
 Worm   148 TRTASTTTALETSASTTSTSSSSSTSFATSTTSKTTGSTPTTSSEDLTRSTSTSGSIQSTGSSSK 212

  Fly   516 ----HSISVEQTTAVPAQPEPESEQEPESKPH------------------PESESASES-ETETE 557
                .|...|.||:..::....|.|  .|||.                  |.||:.:.| .|:..
 Worm   213 TSTDKSTLTENTTSSISKSSSGSSQ--MSKPSSTTTASTAVLSTISHSSTPPSETPTSSPTTDLS 275

  Fly   558 EEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSG 622
            :....|:|.   :|.|||.|..|.::.:...|....|.|.|:|:.|....|.....::|  ..|.
 Worm   276 KSTTSGSTV---SSTSSSGSSRSSTLSSDTSPRITSPFTQATSQKSSTTTTLGSSKSLP--TNSS 335

  Fly   623 SKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSES--------------------VEVFTT 667
            |.|::.:...||.:.|:|.|........|:||:|||..|                    ::|.|.
 Worm   336 SNSKTRTTTTTTTQSTSASSGATDSSSKSTGSTSSSGSSGTSGRTSSSVTETSTTKQTTIKVSTK 400

  Fly   668 PAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVP 732
            .:|...||.::.:||||     |:.|..:|:       ..|..|...|...::::|     |...
 Worm   401 VSPQTSQRSSSDKTSIS-----PSTLTGSTS-------STTIIPVTDLSTAQSSSS-----TSAS 448

  Fly   733 TTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNE 797
            |..:.|.:...|     ||..|:.  ||     |:|.|| :|.|.....|..:.:...:.|...|
 Worm   449 TKLSSFSSTQRA-----THSISSS--TT-----GITETS-SETSETSKSTTRSSKPSTSGLPGYE 500

  Fly   798 VIP--SLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQ 860
            :.|  .:.|.:..|              .|||                  .|.:....||.....
 Worm   501 IFPPDDVFTRSSEP--------------PGTT------------------KTTESTMTTTAETSG 533

  Fly   861 TEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLA 925
            ........|.:...|.|.....|    ||..|.|.....|:..|:......|.||....|..:.:
 Worm   534 DTTTFKSNENSATNTRSSTESTE----PVTKPNTEKSSSTSVLPSDKTTSIPDTTENSKSSKTSS 594

  Fly   926 TETPTLPPTLPPVTLP--PVTQPPPTIPPTPPSTQSAQTLPPPTSA-INVYTTP--DGPPTASQT 985
            |.|.|||........|  |.|....|...|.|::....:|..|:|: |.|.|||  ...||||..
 Worm   595 TTTTTLPSGSTSDVKPSWPATSKLSTQGSTSPASIPTISLDQPSSSQIAVSTTPILTAIPTASSQ 659

  Fly   986 KPSVT-ESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNG---GT--C---------VT 1035
            |.|.: .:|...|.:::.||....|.....|   |..| |:.|.:|   ||  |         :.
 Worm   660 KSSTSGNTSPATESSSSSSTSTSQSTSTTTE---DPAC-KVQCPSGYLIGTSSCFLLVPASSKIN 720

  Fly  1036 TSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRA 1100
            :.:.:...|:...:..|..|..|..||..        |:.::..|..::|.:.
 Worm   721 SYQSALSYCKTTDKQSLASLDKIRDNADI--------RLIQESAGLRNIDWIY------------ 765

  Fly  1101 TNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTG---HEITIRAELDF 1162
            .||:       |.|...:       ..|...:|...||::.|.:...|...   ..|:....|..
 Worm   766 ANGI-------GGKKERF-------DKMADVYSIFNQTLVSSPISVTVGISEIFENISALCVLPQ 816

  Fly  1163 SRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQ 1227
            ..|.|.|:.     :.:.::.|..|..|                 ...|.          |.|.:
 Worm   817 YCNSTECDV-----EKIFLAYDYFTSFK-----------------EYAGT----------LQPRR 849

  Fly  1228 SGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACLSSPCRNGAAC--------IKIETND 1284
            |||  ..||:..|             ..|.:| |..|..: .|..:...|        |:..||:
 Worm   850 SGS--VACLYGNR-------------KTFTVT-CNELGAI-YPNPSNIDCGESVQERKIRDTTNE 897

  Fly  1285 LDEN-------GEK-----------AEKWKCKCPTGYMGPTC--EISVCEDNPCQYGGTCVQFPG 1329
            :..:       |.|           .:.:||.|...:...||  ..:.|....|...|.|.. ..
 Worm   898 MVSSCKVCFGRGTKECQPVTNSDGVVQGYKCVCKEPFKMATCWRASNPCTPEACGKNGVCTS-EL 961

  Fly  1330 SGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQIS 1394
            :...|.|..|..|..||....   ..:.|.: |.||.|..|:.:. .:.|:|         .:::
 Worm   962 AEVSCKCNWGYAGDRCEKEKS---KEYKGDL-GYSSVVGATITLG-GFLLKL---------GKLA 1012

  Fly  1395 LLAFFGQSGYHDEKSD 1410
            :|.|...|...|:..|
 Worm  1013 VLGFGVSSEQGDDPQD 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eys	NP_001027571.3	EGF_CA	184..218	CDD:238011
		EGF_CA	220..256	CDD:238011
		EGF_CA	<270..298	CDD:238011
		EGF_CA	301..336	CDD:238011
		EGF	342..371	CDD:278437
		EGF_CA	378..413	CDD:238011
		Laminin_G_2	1096..1244	CDD:280389	27/150 (18%)
		EGF_CA	1314..1346	CDD:238011	7/31 (23%)
		LamG	1355..1521	CDD:238058	13/56 (23%)
		EGF	1549..1578	CDD:278437
		EGF_CA	1585..1621	CDD:238011
		Laminin_G_2	1723..1856	CDD:280389
		LamG	1956..2144	CDD:238058
Y70G10A.2	NP_499266.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I3421
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050