DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eys and txt-5

DIOPT Version :9

Sequence 1:	NP_001027571.3	Gene:	eys / 3771890	FlyBaseID:	FBgn0031414	Length:	2176	Species:	Drosophila melanogaster
Sequence 2:	NP_505019.2	Gene:	txt-5 / 183289	WormBaseID:	WBGene00016499	Length:	356	Species:	Caenorhabditis elegans

Alignment Length:	301	Identity:	70/301 - (23%)
Similarity:	101/301 - (33%)	Gaps:	106/301 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 TTRKSVTATRSLKLNPNILLPTLRILARGLLLPALILAILVGSSQAGFACLSNP---CVFGVCID 160
            :|.|:.:...||.|:.|||....|||.:..:|..:              .|.:|   |..|
Worm    15 STTKAQSRDDSLDLDENILSDVHRILQKRSILDNV--------------ALDDPRAECRNG---- 61

  Fly   161 GLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAY------------YNCTCPEGFS 213
            |:.:...|:||.|.||.:|: :::            ||.|::.            ..|.|..|:.
Worm    62 GIYAGGICHCIKGQTGDKCE-HFE------------CVHGLSVGFRFDPESLLFSEPCICEVGWK 113

  Fly   214 GSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIE 278
            |..|:....|    .|.|.|    ...|..|.|...|.||               .||:..:|:|
Worm   114 GEMCDYRPAE----KCGNKG----EWKGDRCECVGSYFGS---------------ECQYTSKCVE 155

  Fly   279 GPGLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILICA 343
            |......|.|..|:.|..|.|.:....|...:|        ...:|.||..|||..||:
Worm   156 GFLRNGRCICDVGFEGDYCDEIVCVYGSPDFKN--------RTLSCDCPDKYTGRRCEQ------ 206

  Fly   344 DNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGP 384
               |:.                   ||...| .:..|:|.|
Worm   207 ---CKK-------------------HGPLIE-PFPHCELDP 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eys	NP_001027571.3	EGF_CA	184..218	CDD:238011	7/45 (16%)
		EGF_CA	220..256	CDD:238011	10/35 (29%)
		EGF_CA	<270..298	CDD:238011	9/27 (33%)
		EGF_CA	301..336	CDD:238011	8/34 (24%)
		EGF	342..371	CDD:278437	2/28 (7%)
		EGF_CA	378..413	CDD:238011	3/7 (43%)
		Laminin_G_2	1096..1244	CDD:280389
		EGF_CA	1314..1346	CDD:238011
		LamG	1355..1521	CDD:238058
		EGF	1549..1578	CDD:278437
		EGF_CA	1585..1621	CDD:238011
		Laminin_G_2	1723..1856	CDD:280389
		LamG	1956..2144	CDD:238058
txt-5	NP_505019.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24033
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010