back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eys and Notch1

DIOPT Version :10

Sequence 1:	NP_001027571.3	Gene:	eys / 3771890	FlyBaseID:	FBgn0031414	Length:	2176	Species:	Drosophila melanogaster
Sequence 2:	NP_032740.3	Gene:	Notch1 / 18128	MGIID:	97363	Length:	2531	Species:	Mus musculus

Alignment Length:	1997	Identity:	403/1997 - (20%)
Similarity:	606/1997 - (30%)	Gaps:	709/1997 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 LLLPALILAILVGSSQAGFACLSNPCVFGVCIDG-----LNSSYSCYCIDGYTGIQCQTNWDECW 187
            ||.|.|.|.:|...:..|..| |.|.  |.|::|     .|.:.:|.|...:.|.:||.: :.|.
Mouse     4 LLTPLLCLTLLPALAARGLRC-SQPS--GTCLNGGRCEVANGTEACVCSGAFVGQRCQDS-NPCL 64

  Fly   188 SSPCQNGGTC--VD--GVAYYNCTCPEGFSGSNCEENVDE-CMSNPCQNGGLCRDRT-NGYICTC 246
            |:||:|.|||  ||  |...|.|:||.||||..|...:|. |::|||:|||.|...| ..|.|.|
Mouse    65 STPCKNAGTCHVVDHGGTVDYACSCPLGFSGPLCLTPLDNACLANPCRNGGTCDLLTLTEYKCRC 129

  Fly   247 QPGYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSP--C 309
            .||:.|..|: ....|.:..   |.:||:|:.... .:.|.||.|:||..|::::|||:.:|  |
Mouse   130 PPGWSGKSCQ-QADPCASNP---CANGGQCLPFES-SYICRCPPGFHGPTCRQDVNECSQNPGLC 189

  Fly   310 QNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPT------CYCVPDY 368
            ::||.|.:::.:|.|||...:||.:||...:.|:.:||||...|.     ||      |.|:|.:
Mouse   190 RHGGTCHNEIGSYRCACRATHTGPHCELPYVPCSPSPCQNGGTCR-----PTGDTTHECACLPGF 249

  Fly   369 HGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQS 433
            .|:.||...|:|. |..|.|||.|:|||:|::|.|||..||..|.     |:..:|.
Mouse   250 AGQNCEENVDDCP-GNNCKNGGACVDGVNTYNCRCPPEWTGQYCT-----EDVDECQ-------- 300

  Fly   434 PPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEG 498
                                                                |.|::..:..
Mouse   301 ----------------------------------------------------LMPNACQNGG--- 310

  Fly   499 VSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPG 563
                    |......|.:.:.|...|.           |..|:...:..||:..:..|..:.:..
Mouse   311 --------TCHNTHGGYNCVCVNGWTG-----------EDCSENIDDCASAACFQGATCHDRVAS 356

  Fly   564 TTARPPTSRS-----------SSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPH 617
            .....|..|:           |:...|..:..|.  |:.||...:..|..:|...:.:    |..
Mouse   357 FYCECPHGRTGLLCHLNDACISNPCNEGSNCDTN--PVNGKAICTCPSGYTGPACSQD----VDE 415

  Fly   618 FEVSGSKSES--------GSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQ 674
            ..:..:..|.        ||.|...::....|...|.|:...|....:.:..::.......:.:.
Mouse   416 CALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMP 480

  Fly   675 RVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFF 739
            ....:...|:.|                     ..|..|.|.........:....:.|.......
Mouse   481 GYEGVYCEINTD---------------------ECASSPCLHNGHCMDKINEFQCQCPKGFNGHL 524

  Fly   740 TEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLIT 804
            .:|..:...:|                     |.::.:..|..|:|              .:.:.
Mouse   525 CQYDVDECAST---------------------PCKNGAKCLDGPNT--------------YTCVC 554

  Fly   805 TTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTT----PQPVEITTGHPLQTEDLI 865
            |.|...||..           ..:...:.|..|:....|...|    .||.  .|||..:|.
Mouse   555 TEGYTGTHCE-----------VDIDECDPDPCHYGSCKDGVATFTCLCQPG--YTGHHCETN--- 603

  Fly   866 GVQEPAVVTTESPFAPA---------ETTVVPVVVPATIAP---------------LGT------ 900
                    ..|....|.         :.:.:.:.:..|..|               .||
Mouse   604 --------INECHSQPCRHGGTCQDRDNSYLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKID 660

  Fly   901 ----AAPPATPAPVPPATTTPPPSPP---------SLATETPTLPPTL-PPVTLPPVTQPPPTIP 951
                |..|.....:...........|         .:|..|...|... .|..|..|.:     .
Mouse   661 GYECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNE-----C 720

  Fly   952 PTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVT----ESSEEVEG-------TNTVSTG 1005
            .:.|....|     ....:|.|.. |..|..|.|...:.    ||:..|.|       :..|.|.
Mouse   721 NSNPCIHGA-----CRDGLNGYKC-DCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTC 779

  Fly  1006 GRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCEL---PIIIRNAAFSGD 1067
            ..|..| |..:....:|....|.|.|||:....|.:|.|.....|..||:   |........||
Mouse   780 REGFSG-PNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSG- 842

  Fly  1068 SYVSHRIYKDIGGHESLDAVLP---------MHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFL 1123
                  :.|:...:||...|.|         :.|...|::...:|    |:.|.|.|
Mouse   843 ------VCKESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHG----ASCQNTNG-------- 889

  Fly  1124 QKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTW 1188
                   .:.|..|.                          .||..|....::|.      :|.
Mouse   890 -------SYRCLCQA--------------------------GYTGRNCESDIDDC------RPN- 914

  Fly  1189 LKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDAL 1253
                                                |..:|...|..::|         .|.|.|
Mouse   915 ------------------------------------PCHNGGSCTDGINT---------AFCDCL 934

  Fly  1254 DGF-------GITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEIS 1311
            .||       .|.||.     |:||:|||.|    |:.:|       .:.|.||.|:.|..||.:
Mouse   935 PGFQGAFCEEDINECA-----SNPCQNGANC----TDCVD-------SYTCTCPVGFNGIHCENN 983

  Fly  1312 V--CEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEV--ALPSFSGSVNGLSSFVAYTVP 1372
            .  |.::.|..|||||....| :.||||.|..|.||::::..  :.|...|. ....|:..|...
Mouse   984 TPDCTESSCFNGGTCVDGINS-FTCLCPPGFTGSYCQYDVNECDSRPCLHGG-TCQDSYGTYKCT 1046

  Fly  1373 IPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQ 1437
            .|                                           |||..|.           .|
Mouse  1047 CP-------------------------------------------QGYTGLN-----------CQ 1057

  Fly  1438 KPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTL 1502
            ..:.:...||        .:.|.:.| ..:.:::...||..:|...|||.:
Mouse  1058 NLVRWCDSAP--------CKNGGRCW-QTNTQYHCECRSGWTGVNCDVLSV-------------- 1099

  Fly  1503 PHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRG--------VGQCGT------RECHRHA 1553
                       .|....|.:...||:..|........|        .|..|:      .||..:.
Mouse  1100 -----------SCEVAAQKRGIDVTLLCQHGGLCVDEGDKHYCHCQAGYTGSYCEDEVDECSPNP 1153

  Fly  1554 CQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGK 1618
            ||:...|..:...|:|.|..|::|..|::..|.|  .:..|....||:.|.|.|:|.||.|..|.
Mouse  1154 CQNGATCTDYLGGFSCKCVAGYHGSNCSEEINEC--LSQPCQNGGTCIDLTNSYKCSCPRGTQGV 1216

  Fly  1619 NCEEVIRSLSDVSLTGRRSYL--AVRWPYLYDGG---DKLGAKRSQMVSYRNFTKKLMPPKPITT 1678
            :||        :::......|  |.|.|..::.|   |::|....           ..||
Mouse  1217 HCE--------INVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTC-----------TCPP----- 1257

  Fly  1679 PSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQD 1743

Mouse  1258 ----------------------------------------------------------------- 1257

  Fly  1744 KKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWH-KIKMAQRGRWLTLWVEGSASSAL 1807
               |||....:|.|.|. :|.|.:.......|:  .:.::| :.:....||.....:.|....
Mouse  1258 ---GFVGERCEGDVNEC-LSNPCDPRGTQNCVQ--RVNDFHCECRAGHTGRRCESVINGCRGK-- 1314

  Fly  1808 APSAEVLVEPDSLLYIGGLKDVSKLPHNAISGF----PIPFRGCVRGLVVSGTRIVLNETNIVES 1868
             |...           ||   |..:..|...||    |..|.|..
Mouse  1315 -PCKN-----------GG---VCAVASNTARGFICRCPAGFEGAT-------------------- 1344

  Fly  1869 RNIRDC--DGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLI---PCKNNGRC 1928
                 |  |...||...|.:||.| :.....|.|:|.....|..|::..:...:   ||.|.|.|
Mouse  1345 -----CENDARTCGSLRCLNGGTC-ISGPRSPTCLCLGSFTGPECQFPASSPCVGSNPCYNQGTC 1403

  Fly  1929 LRSG-----RCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRI 1970
            ..:.     ||.||..:.|..|.|     ...||.|.:...:|||:|
Mouse  1404 EPTSENPFYRCLCPAKFNGLLCHI-----LDYSFTGGAGRDIPPPQI 1445

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.