DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eys and F35D2.3

DIOPT Version :9

Sequence 1:	NP_001027571.3	Gene:	eys / 3771890	FlyBaseID:	FBgn0031414	Length:	2176	Species:	Drosophila melanogaster
Sequence 2:	NP_495588.2	Gene:	F35D2.3 / 174229	WormBaseID:	WBGene00018041	Length:	256	Species:	Caenorhabditis elegans

Alignment Length:	262	Identity:	66/262 - (25%)
Similarity:	92/262 - (35%)	Gaps:	85/262 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 ILARGLLLPALILAILVGSSQAGFACLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECW 187
            :|.|..::..::|:.:..:|      |.||       ..|...|
Worm     1 MLFRSFIIGFVLLSAIAANS------LINP-------SNLTDDY--------------------- 31

  Fly   188 SSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYI-CTCQPGYL 251
               |:|||:.|:|    .|.|...:.|..||.       ..|.|||. |....|.: |.|..|..
Worm    32 ---CKNGGSIVNG----KCECTLRYEGPQCER-------ERCLNGGR-RHSAKGTVRCHCPYGLS 81

  Fly   252 GSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCV 316
            |..|| .|..||.|.       |:.:||     .|:|...|.|..|.       ...|.| |:..
Worm    82 GDRCE-KVTYCEPGK-------GKLVEG-----KCECFERWTGLFCN-------MRTCFN-GIPT 125

  Fly   317 DKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQ 381
            ..|..: |.|.:||||..|:..::      |:|......|.   .|.|...|.|:.||    :|.
Worm   126 GGLDGF-CLCDVGYTGPFCDAPLI------CENGGSVTQEN---ECACTAGYTGDHCE----QCA 176

  Fly   382 LG 383
            :|
Worm   177 IG 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eys	NP_001027571.3	EGF_CA	184..218	CDD:238011	9/33 (27%)
		EGF_CA	220..256	CDD:238011	10/36 (28%)
		EGF_CA	<270..298	CDD:238011	7/27 (26%)
		EGF_CA	301..336	CDD:238011	10/34 (29%)
		EGF	342..371	CDD:278437	6/28 (21%)
		EGF_CA	378..413	CDD:238011	2/6 (33%)
		Laminin_G_2	1096..1244	CDD:280389
		EGF_CA	1314..1346	CDD:238011
		LamG	1355..1521	CDD:238058
		EGF	1549..1578	CDD:278437
		EGF_CA	1585..1621	CDD:238011
		Laminin_G_2	1723..1856	CDD:280389
		LamG	1956..2144	CDD:238058
F35D2.3	NP_495588.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910