DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eys and T19D12.6

DIOPT Version :9

Sequence 1:	NP_001027571.3	Gene:	eys / 3771890	FlyBaseID:	FBgn0031414	Length:	2176	Species:	Drosophila melanogaster
Sequence 2:	NP_495350.4	Gene:	T19D12.6 / 174097	WormBaseID:	WBGene00020581	Length:	779	Species:	Caenorhabditis elegans

Alignment Length:	828	Identity:	158/828 - (19%)
Similarity:	271/828 - (32%)	Gaps:	277/828 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1436 TQKPIDFRLDAPRVPYEIKVGRIGRQAWLSV--DGKFNITGRSPGSGS----------------- 1481
            |...|.|:||..:.......|.:....:||:  ||...|.....|.|:
Worm   130 TNITIQFKLDEHKDGIIFFAGELMGDDFLSITLDGPNVIMRHDCGEGTIEDMYHGKFAIGEWHEI 194

  Fly  1482 -----RMDVLPILYLGGH-------EIANFNTL-----------PHDLPL-------HSGFQGCI 1516
                 ..|:..|:..|||       |..|:..:           ||::..       ..||:||:
Worm   195 NVWRKNCDLTEIIVDGGHKLVDHADEFKNYKGITMDEGVFLGAAPHNIEFLQQKTGAFEGFRGCV 259

  Fly  1517 YDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCA 1581
             .:.:..|:|.:...||
Worm   260 -RLLVVNGEVLLNTNET------------------------------------------------ 275

  Fly  1582 QPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYL 1646
                     .||..:.:     || |.|    |......|:..|.:..| :||.:.
Worm   276 ---------INKALDSS-----VN-YYC----GEEEPKLEKKKRKIIKV-MTGDKE--------- 311

  Fly  1647 YDGGDKLGAKRSQM--VSYRNFTKKLMPP-------KPITTPSSHFVMKLLNEVEKQRSFSPVPL 1702
            .|..:.....:.:|  ::.|...|.|..|       .|.:.|..|.::|.:...::..:.:|.|.
Worm   312 NDNEESDDIIQIEMFDLTQRGIPKILETPGMHMSTQSPTSLPLGHPILKEIIVQQEHVTTTPAPS 376

  Fly  1703 MGSKSFEEHHRVQFF----------------FIEFQLRPLSER--GLLLYFGTLNNNQDKKIGFV 1749
            ..|.......:|..|                ::|..::..:|:  |:|.::     .:|.|  |:
Worm   377 STSTKSSITWKVAHFNGNSNVIVPAPDSILSYLELSIQFKTEKPSGVLFFW-----KEDSK--FL 434

  Fly  1750 SLSLQGGVVEFRIS-GPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTL------WVEGSASSAL 1807
            .::::...::...| |..  .|::||...:::..|||:::.:.|:.:.|      |||    |.|
Worm   435 IVTVENSFIKVYASLGVD--ATILRSENAVSLYHWHKLEVWRSGKGVLLKVNKQGWVE----SEL 493

  Fly  1808 APSAEVLVEPDSLLYIGGLKDVSKLPH--NAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRN 1870
            ..|...::|....::||.|.| :.:|.  ..|.|    |.|||:.:.::|..|::..|   .:.|
Worm   494 HASKLEIIEETGNIFIGSLDD-NDIPSVVKDIEG----FAGCVKRIRLNGKAILMQST---YATN 550

  Fly  1871 IRDCDGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLIPCKNNGRCLRSGR-- 1933
            :.:|                                      :.:.|....|.|  :||....
Worm   551 VTEC--------------------------------------FQDPCSTFGCPN--KCLAHNSMP 575

  Fly  1934 -CSCPNGWGGFYCEI-AMSKPTTPSFRGNSYLILPPPRIPMKDKRRGPSLYVRPREAIQVSLNF- 1995
             |.|.....|..|.: :.|:.:...|.|.|||.|....:  .....|.||        .:::||
Worm   576 VCQCEWPMSGRKCSVTSESEISAMKFSGLSYLELDNEAV--MSHITGDSL--------DMAVNFK 630

  Fly  1996 --STIEPDGLLLWS----EHERSKFLGLGLEAGH-LKLASNLLGSTNDTVRAPASGFIADGAWHW 2053
              :|.:....::.|    .|| ..|..|.::... ::.|.| |||....:..|..  |.|..|..
Worm   631 IQNTTQTVRQIVISAGDITHE-DDFFELSIDTNRFVRFALN-LGSGTIVLTHPKR--IEDERWIT 691

  Fly  2054 TSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYLGGFP 2118
            ..|:..|:.::|.::||...|...|||...|.                     .|.::|....|.
Worm   692 VEVIRKRNLVKLSVNGEDPITGFAPEGAEQLN---------------------VYRNIFIGNNFT 735

  Fly  2119 NSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAIISDFSTYQGENIGSC 2166
            ...|    ..||.|....||:..::|  :.|.|..........||..|
Worm   736 PDGS----PDGRDFTGLDGCIISLRF--DQTTISHPKQAKTAINIQDC 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eys	NP_001027571.3	EGF_CA	184..218	CDD:238011
		EGF_CA	220..256	CDD:238011
		EGF_CA	<270..298	CDD:238011
		EGF_CA	301..336	CDD:238011
		EGF	342..371	CDD:278437
		EGF_CA	378..413	CDD:238011
		Laminin_G_2	1096..1244	CDD:280389
		EGF_CA	1314..1346	CDD:238011
		LamG	1355..1521	CDD:238058	26/133 (20%)
		EGF	1549..1578	CDD:278437	0/28 (0%)
		EGF_CA	1585..1621	CDD:238011	7/35 (20%)
		Laminin_G_2	1723..1856	CDD:280389	34/143 (24%)
		LamG	1956..2144	CDD:238058	45/195 (23%)
T19D12.6	NP_495350.4	FXa_inhibition	26..62	CDD:291342
		LamG	109..265	CDD:238058	26/135 (19%)
		LamG	388..537	CDD:238058	37/166 (22%)
		LamG	601..758	CDD:238058	46/197 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910