DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eys and Hspg2

DIOPT Version :9

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:XP_030109089.1 Gene:Hspg2 / 15530 MGIID:96257 Length:4398 Species:Mus musculus


Alignment Length:3224 Identity:619/3224 - (19%)
Similarity:922/3224 - (28%) Gaps:1485/3224 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 RNHLLKMPTATIEKPTITATIASSSSTSTSTTRKSVTATRSLKLNPNILLPTLRILARGLLLPAL 133
            |.||| |..|.:::..:.||.:|                          :|.          .|.
Mouse  1495 REHLL-MALADLDELLVRATFSS--------------------------VPR----------AAS 1522

  Fly   134 ILAILVGSSQAGFACLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCV 198
            |.|:.:..:|.|.:  |.|....|        ..|.|..||.|:.||         .|..|.|..
Mouse  1523 ISAVSLEVAQPGPS--SGPRALEV--------EECRCPPGYVGLSCQ---------DCAPGYTRT 1568

  Fly   199 DGVAYYN----CTC--------PEGFSGSNCEENV---------------------DEC------ 224
            ....|..    |.|        ||..:.|.|:.|.                     ::|      
Mouse  1569 GSGLYLGQCELCECNGHSDLCHPETGACSRCQHNTAGEFCELCATGYYGDATAGTPEDCQPCACP 1633

  Fly   225 MSNP-------CQNGGLCRDRTNGYICT-CQPGYLGSHCELDVAVCETG-------TGARCQ--- 271
            ::||       |::.|     ..||.|| |:|||.|.:||    .|..|       .|.|||   
Mouse  1634 LTNPENMFSRTCESLG-----AGGYRCTACEPGYTGQYCE----QCAPGYEGDPNVQGGRCQPLT 1689

  Fly   272 --------HGGECIEGPGLEFTCDCPAGWHGRICQ-------------EEINECASSPCQN---- 311
                    |....:...|         |.|...||             |:.....||..|.    
Mouse  1690 KESLEVQIHPSRSVVPQG---------GPHSLRCQVSGSPPHYFYWSREDGRPLPSSAQQRHQGS 1745

  Fly   312 ----GGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEE-------GVP-TCYC 364
                ..|.......|.|.|.......|...|:|: |:.|.:...:.:.|:       |.. |..|
Mouse  1746 ELHFPSVQPSDAGVYICTCRNLIHTSNSRAELLV-AEAPSKPITVTVEEQRSQSVRPGADVTFIC 1809

  Fly   365 V-----PDY-------HGEKCEFQYDECQLGPRCM--NGGVCIDGVD-----TFSCS-------- 402
            .     |.|       |..|         |..|.|  ||.:.|..|.     |:.|:        
Mouse  1810 TAKSKSPAYTLVWTRLHNGK---------LPSRAMDFNGILTIRNVQPSDAGTYVCTGSNMFAMD 1865

  Fly   403 ---------------------CPPLLT---GMLCE--CLMVGEESLDCNYT-APATQSPPRRTTT 440
                                 .||.||   |...|  |...|..:....:. .|:.|.|.:....
Mouse  1866 QGTATLHVQVSGTSTAPVASIHPPQLTVQPGQQAEFRCSATGNPTPMLEWIGGPSGQLPAKAQIH 1930

  Fly   441 TSTMAPPTVRP----------------------------------VTPPETTV------------ 459
            ...:..|.:.|                                  |:|..|.|            
Mouse  1931 NGILRLPAIEPSDQGQYLCRALSSAGQHVARAMLQVHGGSGPRVQVSPERTQVHEGRTVRLYCRA 1995

  Fly   460 -----------------SPSRASEEVEI----------------IVVTTS----APAEVVTSVLS 487
                             .|...||..:|                :.|.||    |.|.:...|||
Mouse  1996 AGVPSASITWRKEGGSLPPQARSENTDIPTLLIPAITAADAGFYLCVATSPTGTAQARIQVVVLS 2060

  Fly   488 PS----------SSSSSSEEGVSVE--------------------------------IKTPTVAP 510
            .|          |||.|..||.:::                                ::.|.|:|
Mouse  2061 ASGANSVPVRIESSSPSVTEGQTLDLNCAVMGLTYTQVTWYKRGGSLPPHAQVHGSRLRLPQVSP 2125

  Fly   511 PESGSHSISVEQ---------TTAVPAQPEPESEQEPESKPHP----ESESASESETETEEE--I 560
            .:||.:...||.         ..:|...|.......|.:...|    ||.|:..:|.:|.:.  :
Mouse  2126 ADSGDYVCRVESDVGPKEASIVVSVLHSPHSGPSYTPATSITPPIRIESSSSHVAEGQTLDLNCV 2190

  Fly   561 IPGTT------------ARPPTSRS---------------------SSSSEESPSIFTTLP---- 588
            :||..            ||..|..|                     .|...|:..:.|..|    
Mouse  2191 VPGQAQVTWRKRGGSLPARHQTHGSLLRLHQVSPADSGEYVCHVVLGSEHTETSVLVTIEPAESI 2255

  Fly   589 PLPG-----KPQTSASSESSGE------VVTSEEYTTVPHFEVSGS------------------- 623
            |.||     :.:.|:|:.:.|.      ||..:.:..|..::..||                   
Mouse  2256 PAPGPAPPVRIEASSSTVTEGHMLDLNCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYILQASP 2320

  Fly   624 --------KSESGSEEVTTVRPTA--------APSITISVDITSSGSSSSSSESVEV-------- 664
                    ::.:|.|...||..|.        .|..|..:.|.||.|..:..:::::        
Mouse  2321 ADAGEYVCRAGNGQEATITVTVTRNHGANLAYPPGSTSPIRIESSSSHVAEGQTLDLNCVVQGQA 2385

  Fly   665 ----------FTTPA---------------PV----FVQRV----TTIETSISIDYVTPTPLPET 696
                      .:.||               ||    :|.||    ..:|:|:.:     |..|..
Mouse  2386 HAQVTWHKRGGSLPARHQTHGSLLRLHQVSPVDSGEYVCRVEGGAVPLESSVLV-----TIEPAG 2445

  Fly   697 TTPRVVPVPRPTFAPEPPLDVVETTAS-----------------TH------------------- 725
            |.|.|:|..|           :|:::|                 ||                   
Mouse  2446 TAPGVIPPVR-----------IESSSSHVSEGQSLDLNCLVSGQTHPQISWHKRGGSLPARHQVH 2499

  Fly   726 ----HLWTEVPTTAAPFFTE-------YPAEVLITTHRT-SAGRFTTVQPPAGVTTTSPTEDSSV 778
                .|....||.:..:...       ..|.:|:|..:| |.....:|..|..:.::||:..:..
Mouse  2500 GSRLRLLQVTPTDSGEYVCRVVSGSGTQEASILVTIQQTLSPSHSQSVVHPVRIESSSPSLANGH 2564

  Fly   779 ELP--------TPHT-------------PQIV--------VTILDSNEVI-----------PSLI 803
            .|.        ||||             .|||        ||..||.|.:           .|||
Mouse  2565 TLDLNCLVASLTPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSQETSLI 2629

  Fly   804 TT-------------------TGSPTT-------------------------------HHHHH-- 816
            .|                   |.|||.                               .|..|  
Mouse  2630 VTIESRGPSHVPSVSPPMRIETSSPTVTEGQTLDLNCVVVGRPQATITWYKRGGSLPFRHQAHGS 2694

  Fly   817 ----HH-------------------------------------------------PHHEAEGTTL 828
                ||                                                 ....|||.||
Mouse  2695 RLRLHHMSVADSGEYVCRANNNIDAQETSIMISVSPSTNSPPAPASPAPIRIESSSSRVAEGQTL 2759

  Fly   829 Q---PLEEDEH--------------HHHHHHDEFTTPQPVEITTGH----------PLQTEDLI- 865
            .   .:....|              ||..|.......|.....:|.          ||:...|: 
Mouse  2760 DLNCVVPGHAHAQVTWHKRGGSLPTHHQTHGSRLRLYQVSSADSGEYVCSVLSSSGPLEASVLVS 2824

  Fly   866 ------GVQEPAVV------TTESPFAPAETTVVPVVVP------ATIAPLGTAAP--------- 903
                  .|..|.||      |:.|..|..:|..:..|||      .|....|.:.|         
Mouse  2825 ITPAAANVHIPGVVPPIRIETSSSRVAEGQTLDLSCVVPGQAHAQVTWHKRGGSLPAGHQVHGHM 2889

  Fly   904 -------PA---------------------------TPAPVPPATTTPP---PSPPSLATETPTL 931
                   ||                           .|:|:|......|   .|..|..||..|:
Mouse  2890 LRLNRVSPADSGEYSCQVTGSSGTLEASVLVTIEASEPSPIPAPGLAQPVYIESSSSHLTEGQTV 2954

  Fly   932 P-------------------PTLPP-----------VTLPP------VTQPPPTIPP-------- 952
            .                   .:||.           ..|.|      |.|...:..|        
Mouse  2955 DLKCVVPGQAHAQVTWHKRGSSLPARHQTHGSLLRLYQLSPADSGEYVCQVAGSSHPEHEASFKL 3019

  Fly   953 TPPSTQSAQ--------TLPPPTSAI--------------------------------NVYTTPD 977
            |.||:|::.        ::.||:|.:                                ||:.:|:
Mouse  3020 TVPSSQNSSFRLRSPVISIEPPSSTVQQGQDASFKCLIHEGATPIKVEWKIRDQELEDNVHISPN 3084

  Fly   978 GP-PTASQTKPS--------------VTES--SEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKL 1025
            |. .|...|:||              :.:|  :..|.|..|||.       :||   |.|. :|:
Mouse  3085 GSIITIVGTRPSNHGAYRCVASNVYGMAQSVVNLSVHGPPTVSV-------LPE---GPVH-VKM 3138

  Fly  1026 GCYNGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPM 1090
            |......|:::.| .|...|:.|.|    :|:.:....|                     .::..
Mouse  3139 GKDITLECISSGE-PRSSPRWTRLG----IPVKLEPRMF---------------------GLMNS 3177

  Fly  1091 HIQLKVRT-RATNGLIMLAAAQGTKG--GHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGH 1152
            |..||:.: :.::....:..||...|  ...:.|.:..|.:    :.|...:.:.|.|..:..||
Mouse  3178 HAMLKIASVKPSDAGTYVCQAQNALGTAQKQVELIVDTGTV----APGAPQVQVEESELTLEAGH 3238

  Fly  1153 EITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPT---WLKL---LP------------PRL--- 1196
            ..|:           ||:|          :|:.|.   |.||   ||            ||:   
Mouse  3239 TATL-----------HCSA----------TGNPPPTIHWSKLRAPLPWQHRIEGNTLVIPRVAQQ 3282

  Fly  1197 --------------HTPEAILNTWLHLGGAPQAPI---------GLIIEL--------------- 1223
                          ||...::   ||:...|.|.|         |.:::|               
Mouse  3283 DSGQYICNATNSAGHTEATVV---LHVESPPYATIIPEHTSAQPGNLVQLQCLAHGTPPLTYQWS 3344

  Fly  1224 --------------------PPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACL- 1267
                                |.....||...|..:.|: |.| |.|...|      ..||.:.| 
Mouse  3345 LVGGVLPEKAVARNQVLRLEPTVPEDSGRYRCQVSNRV-GSA-EAFAQVL------VQGSSSNLP 3401

  Fly  1268 -------SSP---------CRNGAACIKIETNDLDENGEKAEKW---KCKCPTGYMGPTCEISVC 1313
                   |:|         .||..|.::......:|.|... :|   ..:.|.|:       ||.
Mouse  3402 DTSIPGGSTPTVQVTPQLETRNIGASVEFHCAVPNERGTHL-RWLKEGGQLPPGH-------SVQ 3458

  Fly  1314 E--------DNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYT 1370
            :        |..||  ||        |:|..    ||.:             |.....:..:...
Mouse  3459 DGVLRIQNLDQSCQ--GT--------YVCQA----HGPW-------------GQAQATAQLIVQA 3496

  Fly  1371 VP------------IPLEYSLELSFKILPQTMSQISLLAFFG-------QSG-----YHDEKSD- 1410
            :|            :.:.:|:|.....|.....|::.....|       |||     .|.|.:| 
Mouse  3497 LPSVLINVRTSVHSVVVGHSVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGSIIRIAHVELADA 3561

  Fly  1411 -------HLAVSFIQGYIML------------------------------------TWNLGAG-- 1430
                   ..|....|.:::|                                    ||:...|  
Mouse  3562 GQYRCAATNAAGTTQSHVLLLVQALPQISTPPEIRVPAGSAAVFPCMASGYPTPAITWSKVDGDL 3626

  Fly  1431 -------------------------------------------PRRI---FTQKP---------- 1439
                                                       |.|:   |||.|          
Mouse  3627 PPDSRLENNMLMLPSVRPEDAGTYVCTATNRQGKVKAFAYLQVPERVIPYFTQTPYSFLPLPTIK 3691

  Fly  1440 ---------IDFRLD------------------APRVPYEIKVGRIGRQAWLSVD---------- 1467
                     |.||.|                  |.|.|..|..|.:|.:.....|          
Mouse  3692 DAYRKFEIKITFRPDSADGMLLYNGQKRSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIRH 3756

  Fly  1468 ------GKFN--------------------ITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDL 1506
                  |:|:                    :.|.|.|....:|:...|||||:  .::..:| ..
Mouse  3757 PTPLALGQFHTVTLLRSLTQGSLIVGNLAPVNGTSQGKFQGLDLNEELYLGGY--PDYGAIP-KA 3818

  Fly  1507 PLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACL-QHGATFTCI 1570
            .|.|||.||:.:::::..:|..   ....:...|:..|.|  |....||:.|.|. ...:::||:
Mouse  3819 GLSSGFVGCVRELRIQGEEVVF---HDVNLTTHGISHCPT--CQDRPCQNGGQCQDSESSSYTCV 3878

  Fly  1571 CQEGWYGPLCAQPTNPCDSFNNKCYEDATCV--PLVNGYECDCPVGRTGKNCEEVIRSLSDVSLT 1633
            |..|:.|..| :.:.........|..|||||  |...||.|.|.:||:|..|||.: :::..|::
Mouse  3879 CPAGFTGSRC-EHSQALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGVRCEEGV-TVTTPSMS 3941

  Fly  1634 GRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFS 1698
            |..||||:                                 |..|                    
Mouse  3942 GAGSYLAL---------------------------------PALT-------------------- 3953

  Fly  1699 PVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRIS 1763
                      ..||.::   ::.:.:||...|:||:.|..:...:   .||||::.||.:|||..
Mouse  3954 ----------NMHHELR---LDVEFKPLEPNGILLFSGGKSGPVE---DFVSLAMVGGHLEFRYE 4002

  Fly  1764 GPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGS----ASSALAPSAEVLVEPDSLLYIG 1824
            ..|. :.|:||...|.:|.||::...:..:..:|.|:|.    .||   |.....:...:|||:|
Mouse  4003 LGSG-LAVLRSHEPLTLGRWHRVSAERLNKDGSLRVDGGRPVLRSS---PGKSQGLNLHTLLYLG 4063

  Fly  1825 GLK-DVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDC-DGTACGGDSCESG 1887
            |:: .|...|...:|..   |.|||..:.|:|.|:.|. .:.:.|:.:..| |.:.|....|::|
Mouse  4064 GVEPSVQLSPATNMSAH---FHGCVGEVSVNGKRLDLT-YSFLGSQGVGQCYDSSPCERQPCQNG 4124

  Fly  1888 GHCWLDEKLQPHCICPEYAKGDRCEYSET-CKL-IPCKNNGRCLRSGRCSCPNGWGGFYCEIAMS 1950
            ..|....:.:..|:|.:..|||.||:.|. |:| .||.|.|.| |..||.|..|:.|..|:....
Mouse  4125 ATCMPAGEYEFQCLCQDGFKGDLCEHEENPCQLHEPCLNGGTC-RGARCLCLPGFSGPRCQQGAG 4188

  Fly  1951 KPTTPS-------------------FRGNSYLILPP-------PRIPMKDKRRGPSLYVRPREAI 1989
            .....|                   |..|.:|.||.       |.:|               |.|
Mouse  4189 YGVVESDWHPEGSGGNDAPGQYGAYFYDNGFLGLPGNSFSRSLPEVP---------------ETI 4238

  Fly  1990 QVSLNFSTIEPDGLLLWS----EHERSK-FLGLGLEAGHLKLASNLLGSTNDTVRAPASGFIADG 2049
            :..:..||  .||||||.    |..||| |:.|||:.||| :.|..|||  ...|..:...|.||
Mouse  4239 EFEVRTST--ADGLLLWQGVVREASRSKDFISLGLQDGHL-VFSYQLGS--GEARLVSEDPINDG 4298

  Fly  2050 AWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYL 2114
            .||..:.|.:..|..:|:|||.:.|      |||.|...                .::.:|:.|:
Mouse  4299 EWHRITALREGQRGSIQVDGEDLVT------GRSPGPNV----------------AVNTKDIIYI 4341

  Fly  2115 GGFPNSDSVSRRTKGRFFDPFKGCLQDIQF-----GAEP 2148
            ||.|:   |:..|:|:|.....||::::..     ||.|
Mouse  4342 GGAPD---VATLTRGKFSSGITGCIKNLVLHTARPGAPP 4377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 9/45 (20%)
EGF_CA 220..256 CDD:238011 15/70 (21%)
EGF_CA <270..298 CDD:238011 6/38 (16%)
EGF_CA 301..336 CDD:238011 8/42 (19%)
EGF 342..371 CDD:278437 9/48 (19%)
EGF_CA 378..413 CDD:238011 14/73 (19%)
Laminin_G_2 1096..1244 CDD:280389 37/229 (16%)
EGF_CA 1314..1346 CDD:238011 9/39 (23%)
LamG 1355..1521 CDD:238058 54/354 (15%)
EGF 1549..1578 CDD:278437 9/29 (31%)
EGF_CA 1585..1621 CDD:238011 14/37 (38%)
Laminin_G_2 1723..1856 CDD:280389 42/137 (31%)
LamG 1956..2144 CDD:238058 61/218 (28%)
Hspg2XP_030109089.1 EGF_CA 4153..4184 CDD:238011 13/31 (42%)
LamG 4211..4369 CDD:238058 60/202 (30%)
SEA 80..194 CDD:382994
LDLa 216..251 CDD:238060
Ldl_recept_a 300..336 CDD:365841
LDLa 342..376 CDD:238060
LDLa 385..420 CDD:238060
Ig_Perlecan_like 438..515 CDD:143220
LamB 607..733 CDD:214597
EGF_Lam 781..823 CDD:238012
EGF_Lam 830..887 CDD:238012
Laminin_EGF 896..938 CDD:365839
Laminin_B 1007..1141 CDD:365838
EGF_Lam 1175..1224 CDD:238012
EGF_Lam 1225..1281 CDD:238012
Laminin_EGF 1292..1339 CDD:365839
Laminin_B 1413..1545 CDD:365838 18/96 (19%)
EGF_Lam 1580..1628 CDD:238012 7/47 (15%)
EGF_Lam 1629..1686 CDD:238012 19/65 (29%)
IG_like 1699..1779 CDD:214653 15/88 (17%)
Ig_Perlecan_like 1787..1872 CDD:143231 17/93 (18%)
IG_like 1888..1966 CDD:214653 13/77 (17%)
I-set 1972..2058 CDD:369462 13/85 (15%)
IG_like 2073..2150 CDD:214653 13/76 (17%)
IG 2174..2249 CDD:214652 12/74 (16%)
IG 2269..2342 CDD:214652 12/72 (17%)
IG 2364..2441 CDD:214652 12/81 (15%)
Ig 2450..2535 CDD:386229 12/95 (13%)
IG 2563..2632 CDD:214652 16/68 (24%)
IGc2 2658..2717 CDD:197706 4/58 (7%)
IG_like 2748..2825 CDD:214653 14/76 (18%)
IG 2846..2922 CDD:214652 11/75 (15%)
IG_like 2943..3021 CDD:214653 12/77 (16%)
Ig 3034..3120 CDD:386229 12/85 (14%)
IG_like 3132..3213 CDD:214653 19/107 (18%)
IG 3230..3306 CDD:214652 19/99 (19%)
Ig 3327..3390 CDD:319273 10/64 (16%)
Ig 3428..3494 CDD:386229 17/100 (17%)
Ig 3518..3583 CDD:386229 13/64 (20%)
I-set 3587..3669 CDD:369462 3/81 (4%)
LamG 3676..3833 CDD:238058 33/159 (21%)
EGF_CA 3856..3889 CDD:238011 11/33 (33%)
EGF_CA <3901..3930 CDD:238011 14/28 (50%)
LamG 3942..4091 CDD:238058 50/224 (22%)
EGF 4116..4146 CDD:333761 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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