Protein Alignment eys and EGFLAM

DIOPT Version :10

• Sequence 1: NP_001027571.3
• Gene: eys / 3771890
• FlyBaseID: FBgn0031414
• Length: 2176
• Species: Drosophila melanogaster
• Sequence 2: NP_001192230.1
• Gene: EGFLAM / 133584
• HGNCID: 26810
• Length: 1017
• Species: Homo sapiens
• Alignment Length: 1447
• Identity: 300/1447 - (20%)
• Similarity: 461/1447 - (31%)
• Gaps: 556/1447 - (38%)

  Fly   500 SVEIKTP----------TVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESET 554
            |::.|.|          ||...|.|:.....||..:||.           |:..|
Human    52 SIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPL-----------SRDIP---------- 95

  Fly   555 ETEEEII----PGTTARPPTSRSSSSSE---ESPSIFTTLP-----PLPGKPQTSASSESSGEVV 607
             |.||:|    |||..|...:..|.:.:   .||...|||.     | |..||.
Human    96 -TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLP-PAAPQQ----------- 147

  Fly   608 TSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVF 672
                    ||..|     .|.||...:.:|.|           |.||:.....|||..   .|.|
Human   148 --------PHVIV-----VSDSEVALSWKPGA-----------SEGSAPIQYYSVEFI---RPDF 185

  Fly   673 VQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEP---PLDVVETTASTHHLWTEVPTT 734
            .::.|:|...|.:|.:....|...|..:.......:..|.|   |.|::.|..
Human   186 DKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLC------------ 238

  Fly   735 AAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVI 799
                    |.|       ..:||:.
Human   239 --------PEE-------AGSGRYG---------------------------------------- 248

  Fly   800 PSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHD---EFTTPQPVEITTGHPLQT 861
            |..||..|:                       .||:.......|   .|...:|:..|.|
Human   249 PRYITDMGA-----------------------GEDDEGFEDDLDLDISFEEVKPLPATKG----- 285

  Fly   862 EDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLAT 926
                |.::..|          |:..:.:..|.||:.|   .|| |.|.:|..|..|.|.|
Human   286 ----GNKKFLV----------ESKKMSISNPKTISRL---IPP-TSASLPVTTVAPQPIP----- 327

  Fly   927 ETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTE 991
                                                                    .|.|
Human   328 --------------------------------------------------------IQRK----- 331

  Fly   992 SSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVT--TSEGSRCVCRFDRQGPLCE 1054
                  |.|.|:...|         ..|:.|.:..|.....||.  |..||||.|...:.|..|.
Human   332 ------GKNGVAIMSR---------LFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCS 381

  Fly  1055 LPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYM 1119
            ..|:|:...|.|.|||:....|:     |..|   ..|.|:.|..|.:||::.........|.:|
Human   382 EDIVIQYPQFFGHSYVTFEPLKN-----SYQA---FQITLEFRAEAEDGLLLYCGENEHGRGDFM 438

  Fly  1120 ALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSG- 1183
            :|.:.:..:||:|:||....::.. ||.:..|...|:....|      ..|..|.:|:...::|
Human   439 SLAIIRRSLQFRFNCGTGVAIIVS-ETKIKLGGWHTVMLYRD------GLNGLLQLNNGTPVTGQ 496

  Fly  1184 DQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREI 1248
            .|..:.|:   ...||       |:|||||.| ..|:   ....:..||.||:.:|.:||:..::
Human   497 SQGQYSKI---TFRTP-------LYLGGAPSA-YWLV---RATGTNRGFQGCVQSLAVNGRRIDM 547

  Fly  1249 ----FGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCE 1309
                .|.||.|..:.||.|
Human   548 RPWPLGKALSGADVGECSS---------------------------------------------- 566

  Fly  1310 ISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIP 1374
             .:|::..|.:||||.......|:||||||..|.:||....:.:|.|..|   |.|:.|  .|.|
Human   567 -GICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRES---LRSYAA--TPWP 625

  Fly  1375 LE---YSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFT 1436
            ||   |...:.|:|..:..|...:|.:    .|.....|.|:::...|::...::.|:|...:.:
Human   626 LEPQHYLSFMEFEITFRPDSGDGVLLY----SYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRS 686

  Fly  1437 QKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNT 1501
            :.|:..     ...:|::|.|..:...|.||.:..:.|.:.|..:::.....:::||  :.|::
Human   687 EDPLTL-----GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGG--VPNYD- 743

  Fly  1502 LPHDLPLHSG----FQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQ 1562
               |:..:||    |.|.|..:.|....:.|....|.||....    ....|.|..|.|.|:|.
Human   744 ---DVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN----AAHPCVRAPCAHGGSCR- 800

  Fly  1563 HGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEE----- 1622
                                                   |...||:||||:|..|.:|::
Human   801 ---------------------------------------PRKEGYDCDCPLGFEGLHCQKECGNY 826

  Fly  1623 ----VIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHF 1683
                :|.::......| ||||.      ||..|.|  ||
Human   827 CLNTIIEAIEIPQFIG-RSYLT------YDNPDIL--KR-------------------------- 856

  Fly  1684 VMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFG--TLNNNQDKKI 1746
                              :.||:|        ..|:.|  :..::.||||:.|  .:..|.|
Human   857 ------------------VSGSRS--------NVFMRF--KTTAKDGLLLWRGDSPMRPNSD--- 890

  Fly  1747 GFVSLSLQ-----------GGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVE 1800
             |:||.|:           .||....::|..|.            |.||::|..:.|:...:.|:
Human   891 -FISLGLRDGALVFSYNLGSGVASIMVNGSFND------------GRWHRVKAVRDGQSGKITVD 942

  Fly  1801 G-SASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNE-- 1862
            . .|.:..:|.....:..:..||:||:|::: |..|         |..:||||...:...|:.
Human   943 DYGARTGKSPGMMRQLNINGALYVGGMKEIA-LHTN---------RQYMRGLVGCISHFTLSTDY 997

  Fly  1863 -----TNIVESRNIRDC 1874
                 .:.|:.:||..|
Human   998 HISLVEDAVDGKNINTC 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eys	NP_001027571.3	EGF_CA	184..218	CDD:238011
		EGF_CA	220..256	CDD:238011
		EGF_CA	<270..298	CDD:238011
		EGF_CA	301..336	CDD:238011
		EGF	342..371	CDD:394967
		EGF_CA	378..413	CDD:238011
		Laminin_G_2	1096..1244	CDD:460494	39/148 (26%)
		EGF_CA	1314..1346	CDD:238011	13/31 (42%)
		LamG	1355..1521	CDD:238058	38/172 (22%)
		EGF	1549..1578	CDD:394967	6/28 (21%)
		EGF_CA	1585..1621	CDD:238011	9/35 (26%)
		Laminin_G_2	1723..1856	CDD:460494	35/146 (24%)
		LamG	1956..2144	CDD:238058
EGFLAM	NP_001192230.1	FN3	36..133	CDD:238020	24/102 (24%)
		FN3	142..234	CDD:238020	29/129 (22%)
		LamG	391..541	CDD:238058	48/178 (27%)
		EGF_CA	560..602	CDD:238011	17/88 (19%)
		LamG	618..765	CDD:238058	35/163 (21%)
		EGF_CA	<792..820	CDD:238011	13/67 (19%)
		Laminin_G_2	868..993	CDD:460494	36/152 (24%)