DRSC/TRiP Functional Genomics Resources

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Protein Alignment eys and EGFLAM

DIOPT Version :9

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:NP_001192230.1 Gene:EGFLAM / 133584 HGNCID:26810 Length:1017 Species:Homo sapiens


Alignment Length:1447 Identity:300/1447 - (20%)
Similarity:461/1447 - (31%) Gaps:556/1447 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   500 SVEIKTP----------TVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESET 554
            |::.|.|          ||...|.|:.....||..:||.           |:..|          
Human    52 SIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPL-----------SRDIP---------- 95

  Fly   555 ETEEEII----PGTTARPPTSRSSSSSE---ESPSIFTTLP-----PLPGKPQTSASSESSGEVV 607
             |.||:|    |||..|...:..|.:.:   .||...|||.     | |..||.           
Human    96 -TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLP-PAAPQQ----------- 147

  Fly   608 TSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVF 672
                    ||..|     .|.||...:.:|.|           |.||:.....|||..   .|.|
Human   148 --------PHVIV-----VSDSEVALSWKPGA-----------SEGSAPIQYYSVEFI---RPDF 185

  Fly   673 VQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEP---PLDVVETTASTHHLWTEVPTT 734
            .::.|:|...|.:|.:....|...|..:.......:..|.|   |.|::.|..            
Human   186 DKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLC------------ 238

  Fly   735 AAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVI 799
                    |.|       ..:||:.                                        
Human   239 --------PEE-------AGSGRYG---------------------------------------- 248

  Fly   800 PSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHD---EFTTPQPVEITTGHPLQT 861
            |..||..|:                       .||:.......|   .|...:|:..|.|     
Human   249 PRYITDMGA-----------------------GEDDEGFEDDLDLDISFEEVKPLPATKG----- 285

  Fly   862 EDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLAT 926
                |.::..|          |:..:.:..|.||:.|   .|| |.|.:|..|..|.|.|     
Human   286 ----GNKKFLV----------ESKKMSISNPKTISRL---IPP-TSASLPVTTVAPQPIP----- 327

  Fly   927 ETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTE 991
                                                                    .|.|     
Human   328 --------------------------------------------------------IQRK----- 331

  Fly   992 SSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVT--TSEGSRCVCRFDRQGPLCE 1054
                  |.|.|:...|         ..|:.|.:..|.....||.  |..||||.|...:.|..|.
Human   332 ------GKNGVAIMSR---------LFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCS 381

  Fly  1055 LPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYM 1119
            ..|:|:...|.|.|||:....|:     |..|   ..|.|:.|..|.:||::.........|.:|
Human   382 EDIVIQYPQFFGHSYVTFEPLKN-----SYQA---FQITLEFRAEAEDGLLLYCGENEHGRGDFM 438

  Fly  1120 ALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSG- 1183
            :|.:.:..:||:|:||....::.. ||.:..|...|:....|      ..|..|.:|:...::| 
Human   439 SLAIIRRSLQFRFNCGTGVAIIVS-ETKIKLGGWHTVMLYRD------GLNGLLQLNNGTPVTGQ 496

  Fly  1184 DQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREI 1248
            .|..:.|:   ...||       |:|||||.| ..|:   ....:..||.||:.:|.:||:..::
Human   497 SQGQYSKI---TFRTP-------LYLGGAPSA-YWLV---RATGTNRGFQGCVQSLAVNGRRIDM 547

  Fly  1249 ----FGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCE 1309
                .|.||.|..:.||.|                                              
Human   548 RPWPLGKALSGADVGECSS---------------------------------------------- 566

  Fly  1310 ISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIP 1374
             .:|::..|.:||||.......|:||||||..|.:||....:.:|.|..|   |.|:.|  .|.|
Human   567 -GICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRES---LRSYAA--TPWP 625

  Fly  1375 LE---YSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFT 1436
            ||   |...:.|:|..:..|...:|.:    .|.....|.|:::...|::...::.|:|...:.:
Human   626 LEPQHYLSFMEFEITFRPDSGDGVLLY----SYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRS 686

  Fly  1437 QKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNT 1501
            :.|:..     ...:|::|.|..:...|.||.:..:.|.:.|..:::.....:::||  :.|:: 
Human   687 EDPLTL-----GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGG--VPNYD- 743

  Fly  1502 LPHDLPLHSG----FQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQ 1562
               |:..:||    |.|.|..:.|....:.|....|.||....    ....|.|..|.|.|:|. 
Human   744 ---DVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN----AAHPCVRAPCAHGGSCR- 800

  Fly  1563 HGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEE----- 1622
                                                   |...||:||||:|..|.:|::     
Human   801 ---------------------------------------PRKEGYDCDCPLGFEGLHCQKECGNY 826

  Fly  1623 ----VIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHF 1683
                :|.::......| ||||.      ||..|.|  ||                          
Human   827 CLNTIIEAIEIPQFIG-RSYLT------YDNPDIL--KR-------------------------- 856

  Fly  1684 VMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFG--TLNNNQDKKI 1746
                              :.||:|        ..|:.|  :..::.||||:.|  .:..|.|   
Human   857 ------------------VSGSRS--------NVFMRF--KTTAKDGLLLWRGDSPMRPNSD--- 890

  Fly  1747 GFVSLSLQ-----------GGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVE 1800
             |:||.|:           .||....::|..|.            |.||::|..:.|:...:.|:
Human   891 -FISLGLRDGALVFSYNLGSGVASIMVNGSFND------------GRWHRVKAVRDGQSGKITVD 942

  Fly  1801 G-SASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNE-- 1862
            . .|.:..:|.....:..:..||:||:|::: |..|         |..:||||...:...|:.  
Human   943 DYGARTGKSPGMMRQLNINGALYVGGMKEIA-LHTN---------RQYMRGLVGCISHFTLSTDY 997

  Fly  1863 -----TNIVESRNIRDC 1874
                 .:.|:.:||..|
Human   998 HISLVEDAVDGKNINTC 1014

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011
EGF_CA 220..256 CDD:238011
EGF_CA <270..298 CDD:238011
EGF_CA 301..336 CDD:238011
EGF 342..371 CDD:278437
EGF_CA 378..413 CDD:238011
Laminin_G_2 1096..1244 CDD:280389 39/148 (26%)
EGF_CA 1314..1346 CDD:238011 13/31 (42%)
LamG 1355..1521 CDD:238058 38/172 (22%)
EGF 1549..1578 CDD:278437 6/28 (21%)
EGF_CA 1585..1621 CDD:238011 9/35 (26%)
Laminin_G_2 1723..1856 CDD:280389 35/146 (24%)
LamG 1956..2144 CDD:238058
EGFLAMNP_001192230.1 FN3 36..133 CDD:238020 24/102 (24%)
FN3 142..234 CDD:238020 29/129 (22%)
LamG 391..541 CDD:238058 48/178 (27%)
EGF_CA 560..602 CDD:238011 17/88 (19%)
LamG 618..765 CDD:238058 35/163 (21%)
EGF_CA <792..820 CDD:238011 13/67 (19%)
Laminin_G_2 868..993 CDD:280389 36/152 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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