DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eys and Agrn

DIOPT Version :10

Sequence 1:NP_001027571.3 Gene:eys / 3771890 FlyBaseID:FBgn0031414 Length:2176 Species:Drosophila melanogaster
Sequence 2:XP_006538554.1 Gene:Agrn / 11603 MGIID:87961 Length:2057 Species:Mus musculus


Alignment Length:2000 Identity:450/2000 - (22%)
Similarity:690/2000 - (34%) Gaps:573/2000 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 ARGLLLPALILAILVGSSQAGFACLSNPCVF-GVCIDGLNSSYSCYC----IDG-YTGIQCQ--- 180
            ||||||.    .:..|..|....| ...|.| .||:......: |.|    .|| |..:..|   
Mouse   378 ARGLLLQ----KVRSGQCQTRDQC-PETCQFNSVCLSRRGRPH-CSCDRVTCDGAYRPVCAQDGH 436

  Fly   181 TNWDECW--SSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYI 243
            |..::||  .:.|:.           ..|.|....|. |::....|....|..|..|..:....:
Mouse   437 TYDNDCWRQQAECRQ-----------QQTIPPKHQGP-CDQTPSPCRGAQCAFGATCTVKNGKAV 489

  Fly   244 CTCQ----PGY----------LGSHCELDV--------------------------AVCETGTGA 268
            |.||    .||          .||.|||:.                          ::||..|| 
Mouse   490 CECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETG- 553

  Fly   269 RCQHGGECIE-------GPGLEFTCDCPAGWHGRICQEEIN----------ECASSPCQNGGVCV 316
            ||....||:|       ..|..:..:|..  |...|..:|:          .|..:.|..|.|| 
Mouse   554 RCVCPSECVESAQPVCGSDGHTYASECEL--HVHACTHQISLYVASAGHCQTCGETVCTFGAVC- 615

  Fly   317 DKLAAYACACP----------MGYTGIN-----------CEEEILI------------CA----- 343
               :|..|.||          .|..|:.           |::::.|            |.     
Mouse   616 ---SAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPCEPAECGSGGSG 677

  Fly   344 ---DNPCQNNALCLMEEGV--------PTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVD 397
               ||.|:.. ||....||        |   ||       |:|........|.|.:.||      
Mouse   678 SGEDNACEQE-LCRQHGGVWDEDSEDGP---CV-------CDFSCQSVLKSPVCGSDGV------ 725

  Fly   398 TFSCSCPPLLTGMLCEC---LMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTV 459
            |:|..|.  |....||.   |.|..:.        |.:.|        |:||  :.|:..|....
Mouse   726 TYSTECH--LKKARCEARQELYVAAQG--------ACRGP--------TLAP--LLPMASPHCAQ 770

  Fly   460 SPSRASEEVEIIVVTTSAPAEVV----TSVLSPSSSSSSSEEGVSVEIK---------------- 504
            :|....::    .||.:....:.    |...:|..|.|.:.:.|:.:..                
Mouse   771 TPYGCCQD----NVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPG 831

  Fly   505 ---------------TPTVAPPESGSHSISVEQTTAV----PAQPEPESEQEPESKP--HPESES 548
                           ||....|. |:.....||.|.:    |....|:..|.|:.:.  |...|:
Mouse   832 FWNFRGIVTDGHSGCTPCSCDPR-GAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEA 895

  Fly   549 ASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYT 613
                     :...|.|.........:|..||:.......|.|                       
Mouse   896 ---------DPTTPVTCVEMHCEFGASCVEEAGFAQCVCPTL----------------------- 928

  Fly   614 TVPHFEVSGSKSESGSEEVTTVRPTAAPSIT----ISVDITSSGSSSSS-----SESVEVFTTPA 669
            |.|.   :.|....||:.||........:|.    :.:.|.|.|....|     |.:....|||.
Mouse   929 TCPE---ANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSPTSASMTTPR 990

  Fly   670 PVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTT 734
            .:..:.:.:..:|:        ||..:||....|.|.||    .|..||.|..||....::|.:.
Mouse   991 HILSRTLASPHSSL--------PLSPSTTAHDWPTPLPT----SPQTVVGTPRSTAATPSDVASL 1043

  Fly   735 AAPFFTEYPA------EVLITTHRTSAGRFTTVQPPAG---VTTTSPTEDSSVELPTP------- 783
            |...|.|..:      |.|......|.|....::||.|   ||...|.|.:|. ..:|       
Mouse  1044 ATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASC-YNSPLGCCSDG 1107

  Fly   784 HTPQIVVTILDSN----------EVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLE---EDE 835
            .||.     |||.          :.:..|....|....:......|..|..|.|.:.:|   :|.
Mouse  1108 KTPS-----LDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDL 1167

  Fly   836 HHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGT 900
            ..:.....:|.:.:..|:..|..::          |:|...  |.|......|.|..|.:..:..
Mouse  1168 FRNSDVKKDFWSIRLRELGPGKLVR----------AIVDVH--FDPTTAFQAPDVGQALLQQIQV 1220

  Fly   901 AAPPATPAPVP-------------PA--TTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPPTI 950
            :.|.|.....|             |.  |.....:..::||...|....|...::.|...|..|.
Mouse  1221 SRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASSVTPRVYPSYTS 1285

  Fly   951 PPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEE 1015
            .|...:|....|..|||:..::    |.|.|....:|                         |: 
Mouse  1286 RPVGRTTAPLTTRRPPTTTASI----DRPRTPGPQRP-------------------------PK- 1320

  Fly  1016 KAGDVDCIKLGCYNGGTC--VTTSEGSRCVCRFDRQGPLCE---LPIIIRNAAFSGDSYVSHRIY 1075
                 .|....|.:||||  :.:.:|..|.|...|.|.:||   ||.:   .||.|.|:::    
Mouse  1321 -----SCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKVQLPSV---PAFKGHSFLA---- 1373

  Fly  1076 KDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTML 1140
                 ..:|.|...:.:.|:.|...|.||::...  ..:|..::||.|..|.:||:|..|....:
Mouse  1374 -----FPTLRAYHTLRLALEFRALETEGLLLYNG--NARGKDFLALALLDGHVQFRFDTGSGPAV 1431

  Fly  1141 LSELETPVNTG--HEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAIL 1203
            |:.| .||..|  |      .|:.||::.  ..:|.|:....:.|:.|:         .|....|
Mouse  1432 LTSL-VPVEPGRWH------RLELSRHWR--QGTLSVDGEAPVVGESPS---------GTDGLNL 1478

  Fly  1204 NTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGD----ALDGFGITECGSL 1264
            :|.|::||.|:..:..:::  ....|.|..||:..|.||.|..|: .|    .:...|:.|||..
Mouse  1479 DTKLYVGGLPEEQVATVLD--RTSVGIGLKGCIRMLDINNQQLEL-SDWQRAVVQSSGVGECGDH 1540

  Fly  1265 ACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTC--EISVCEDNPCQYGGTCVQF 1327
            .|..:||..||.|..:|          |..:.|:||.|..||||  |.:.|:.|||.....|...
Mouse  1541 PCSPNPCHGGALCQALE----------AGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVL 1595

  Fly  1328 PGSGYLCLCPLGKHGHYCEHNLEVA-----LPSFSG----SVNGLSSFVAYTVPIPLEYSLELSF 1383
            ...|..|.||||:.|.:||..||.|     |..|:|    .:.||.:|..   .:..:.:||:.|
Mouse  1596 SRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFER---DLGEKMALEMVF 1657

  Fly  1384 KILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPR 1448
              |.:..|  .||.:.||.  .|.|.|.::::....::...::||.|...|.:::||     |..
Mouse  1658 --LARGPS--GLLLYNGQK--TDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPI-----ALG 1711

  Fly  1449 VPYEIKVGRIGRQAWLSVDGKFNITGRSPGS----GSRMDVLPILYLGGHEIANFNTLPHDLPLH 1509
            ....:.:.|.||:..|.|.....:.|.||.|    .:.:::...||:||  ..:|:.|.....:.
Mouse  1712 TWVRVFLERNGRKGALQVGDGPRVLGESPKSRKVPHTMLNLKEPLYVGG--APDFSKLARGAAVA 1774

  Fly  1510 SGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEG 1574
            |||.|.|..|.|:..|:.......|.|                    |.|               
Mouse  1775 SGFDGAIQLVSLRGHQLLTQEHVLRAV--------------------DVA--------------- 1804

  Fly  1575 WYGPLCAQPTNPC-DSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEE--VIRSLSDVSLTGRR 1636
               |...   :|| .:.:|.|....:|:|....|||.||.|.:|.:||:  |.:|:.|:....  
Mouse  1805 ---PFAG---HPCTQAVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLA-- 1861

  Fly  1637 SYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVP 1701
                      :||        ...:.|.|          ..|.|     :|.||:....:.....
Mouse  1862 ----------FDG--------RTYIEYLN----------AVTES-----ELTNEIPAPETLDSRA 1893

  Fly  1702 LMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPS 1766
            |...|:.:.:|      .|..||..:.:||:|:.|.:....|    :::|::..|.::......|
Mouse  1894 LFSEKALQSNH------FELSLRTEATQGLVLWIGKVGERAD----YMALAIVDGHLQLSYDLGS 1948

  Fly  1767 NHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSAS-SALAPSAEVLVEPDSLLYIGGLKDVS 1830
            ..| |:||...:....|.:::..:..|..:|.|...|. :..:|.....::.|..|::|||:   
Mouse  1949 QPV-VLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQ--- 2009

  Fly  1831 KLPHNAISGFPIP------FRGCVRGLVVSGTRIVLNETNIVESRNIRDC 1874
            |||    .|..:|      |.||:|.:||...::.|.| :.|....:|.|
Mouse  2010 KLP----VGQALPKAYGTGFVGCLRDVVVGHRQLHLLE-DAVTKPELRPC 2054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eysNP_001027571.3 EGF_CA 184..218 CDD:238011 6/35 (17%)
EGF_CA 220..256 CDD:238011 11/49 (22%)
EGF_CA <270..298 CDD:238011 7/34 (21%)
EGF_CA 301..336 CDD:238011 12/65 (18%)
EGF 342..371 CDD:394967 11/44 (25%)
EGF_CA 378..413 CDD:238011 8/34 (24%)
Laminin_G_2 1096..1244 CDD:460494 40/149 (27%)
EGF_CA 1314..1346 CDD:238011 11/31 (35%)
LamG 1355..1521 CDD:238058 45/173 (26%)
EGF 1549..1578 CDD:394967 2/28 (7%)
EGF_CA 1585..1621 CDD:238011 13/36 (36%)
Laminin_G_2 1723..1856 CDD:460494 36/139 (26%)
LamG 1956..2144 CDD:238058
AgrnXP_006538554.1 NtA 33..148 CDD:460825
KAZAL 198..244 CDD:197624
KAZAL 274..319 CDD:197624
Kazal_1 351..391 CDD:395004 7/16 (44%)
KAZAL_FS 423..463 CDD:238052 11/51 (22%)
KAZAL 491..536 CDD:197624 9/44 (20%)
KAZAL 556..601 CDD:197624 8/46 (17%)
KAZAL 621..666 CDD:197624 6/44 (14%)
KAZAL 706..752 CDD:197624 15/68 (22%)
Laminin_EGF 795..837 CDD:395007 4/41 (10%)
Laminin_EGF 849..>885 CDD:395007 9/36 (25%)
KAZAL 924..971 CDD:197624 13/72 (18%)
SEA 1121..1245 CDD:214554 21/135 (16%)
EGF 1322..1352 CDD:394967 10/29 (34%)
Laminin_G_1 1389..1520 CDD:395008 41/152 (27%)
Laminin_G_1 1657..1792 CDD:395008 40/147 (27%)
EGF_CA 1814..1846 CDD:238011 11/31 (35%)
Laminin_G_1 1910..2040 CDD:395008 35/141 (25%)
Blue background indicates that the domain is not in the aligned region.

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