Protein Alignment eys and egflam

DIOPT Version :10

• Sequence 1: NP_001027571.3
• Gene: eys / 3771890
• FlyBaseID: FBgn0031414
• Length: 2176
• Species: Drosophila melanogaster
• Sequence 2: XP_002938236.3
• Gene: egflam / 100485123
• XenbaseID: XB-GENE-968342
• Length: 1035
• Species: Xenopus tropicalis
• Alignment Length: 1221
• Identity: 253/1221 - (20%)
• Similarity: 442/1221 - (36%)
• Gaps: 379/1221 - (31%)

  Fly   745 EVLI------TTHRTSAGRFTTV---QP--PAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEV 798
            ||::      |.||.|.|.::..   :|  |..::|.  .::|.:...:|..||:||  :...||
 Frog   105 EVILVDLKPGTLHRVSVGAYSWAGKGRPSMPRDISTL--PQESCMAPGSPSQPQVVV--VSDTEV 165

  Fly   799 IPS--LITTTGSPTTHHHHHHHPHHEAEGTTLQPLEED--------------------------- 834
            ..|  ..|:.|||...::...:...|.:|..: |:.:.
 Frog   166 AVSWQQNTSEGSPPVQYYSMEYIRPELDGIWI-PIRDQIQINSMVLKGLTPNTKYQFAVKAVNSF 229

  Fly   835 -EHHHHHHHDEFTTPQPVEITTG--------HPLQTEDLIGVQEPAVVTTES------------P 878
             |....|..:...|....|:.:|        .|...:|       ...|.:|            |
 Frog   230 GESLLSHESEIIRTFSTEELGSGSYGEGYVTDPKSDDD-------GYTTDDSDDDIYIDELKPLP 287

  Fly   879 FAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTT---PPPSPPSLATETPTLPPTLPPVTL 940
            ...|.:|.|.|                 ...|.|.|.|   |..|..:::|.|.|:.
 Frog   288 SGKAGSTKVLV-----------------DTKVTPGTYTKIIPLASKSTVSTVTSTIS-------- 327

  Fly   941 PPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTG 1005
               |:.|.|...|..||.::.|                 ..|..||..:.:.
 Frog   328 ---TKAPVTTSATTTSTMASTT-----------------TAAKATKAKMAKD------------- 359

  Fly  1006 GRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSE--GSRCVCRFDRQGPLCELPIIIRNAAFSGDS 1068
             ||:|..|  :..|:.|.:..|.....|:...:  ||:|.|...:.|..||..|.::...|.|.|
 Frog   360 -RGTGFPP--RLFDLTCEETFCPADSFCLNDYDRGGSQCHCNLGKAGGTCENDINVQFPQFYGHS 421

  Fly  1069 YVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFS 1133
            |::....|        ::.....|.|:.|.::.:||::.........|.:|::.:.:..:||:|:
 Frog   422 YMTFEPLK--------NSYQTFQITLEFRAQSDDGLLLYCGENEYGRGDFMSVAIIRRSIQFRFN 478

  Fly  1134 CGLQTMLL-SELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSG-DQPTWLKLLPPRL 1196
            ||..|.:: |:.:..:.:.|.:.:..|        ..|..|.::::..:|. .|..:.|:   ..
 Frog   479 CGTGTAIITSDRKIKLGSWHVVRVYRE--------GTNGWLQLDNSSPISAKSQGQYSKI---TF 532

  Fly  1197 HTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREI----FGDALDGFG 1257
            .||       .::||||.  :..:::  .|.:..||.||:.:|.:||::.::    .|.||.|..
 Frog   533 RTP-------FYIGGAPS--VYWLVK--SAGTNRGFKGCVQSLSLNGRSVDMRQWPLGKALSGAD 586

  Fly  1258 ITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISVCEDNPCQYGG 1322
            :.:                                               |.|.:|::.||..||
 Frog   587 VGD-----------------------------------------------CSIGICDEAPCLNGG 604

  Fly  1323 TCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILP 1387
            ||.......||||||.|..|.:||....:|:|.|:.|....:|     ...|||....|||....
 Frog   605 TCRAKTADSYLCLCPAGFRGRHCEEAFTLAIPQFNESARSFAS-----ARWPLEPHHYLSFMEFD 664

  Fly  1388 QT----MSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPR 1448
            .|    |...::|     ..|..:..|.::::.:.||::..::.|:|...|.|:||:     ...
 Frog   665 MTFRPDMEDGTIL-----YSYDTDSKDFISLTMVNGYVVFRFDCGSGTAVIRTEKPV-----TVG 719

  Fly  1449 VPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQ 1513
            ..:|::..|..|...|.||.:..:.|.|.|..:::.....|::||  :.:::|:..:..:...|.
 Frog   720 QWHELRFSRTARNGILQVDNQKQVYGISEGGFTQIKCNTDLFIGG--VPDYDTVKKNSGVLKPFT 782

  Fly  1514 GCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGP 1578
            |.|..:.|....:::       ::|..                .|..|::.
 Frog   783 GSIQKLVLNDRIISL-------IQGLS----------------SGVNLENA-------------- 810

  Fly  1579 LCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRW 1643
                 .:||  .|..|....:|.|..:.||||||:|..||||::||....::.....||||
 Frog   811 -----NHPC--ANIPCANGGSCRPQHDSYECDCPLGFDGKNCQKVITEAIEIPQFIGRSYL---- 864

  Fly  1644 PYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSF 1708
              :||..|.|                    |.::...|:..|:....|:.
 Frog   865 --IYDNRDIL--------------------KRVSGSRSNLFMRFKTTVKD--------------- 892

  Fly  1709 EEHHRVQFFFIEFQLRPLSERGLLLYFG--TLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTV 1771
                                 |||::.|  .:..|.|    |:||.:|.|.:.|..:..|...::
 Frog   893 ---------------------GLLMWRGDSPIKANTD----FISLGIQQGNIVFSYNLGSGMASI 932

  Fly  1772 VRSVRMLAIGEWHKIKMAQRGRWLTLWVEG-SASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHN 1835
            |.: .....|.||::|..:.|:...:.|:. .|.:..:|.....:..:..||:||:|::: |..|
 Frog   933 VVN-GSFNDGRWHRVKAVRDGQTGKVTVDDYGAITGKSPGLMRQLNINGALYVGGMKEIA-LHTN 995

  Fly  1836 AISGFPIPFRGCVRGLVVSGTRIVLN---------ETNIVESRNIRDCDGT 1877
                     |..:|||:...:...|:         :.|  :.:||..| ||
 Frog   996 ---------RQYLRGLIGCISHFTLSTDFHISLVADAN--DGKNINTC-GT 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eys	NP_001027571.3	EGF_CA	184..218	CDD:238011
		EGF_CA	220..256	CDD:238011
		EGF_CA	<270..298	CDD:238011
		EGF_CA	301..336	CDD:238011
		EGF	342..371	CDD:394967
		EGF_CA	378..413	CDD:238011
		Laminin_G_2	1096..1244	CDD:460494	32/149 (21%)
		EGF_CA	1314..1346	CDD:238011	14/31 (45%)
		LamG	1355..1521	CDD:238058	38/169 (22%)
		EGF	1549..1578	CDD:394967	2/28 (7%)
		EGF_CA	1585..1621	CDD:238011	16/35 (46%)
		Laminin_G_2	1723..1856	CDD:460494	33/135 (24%)
		LamG	1956..2144	CDD:238058
egflam	XP_002938236.3	FN3	34..140	CDD:238020	9/34 (26%)
		FN3	149..243	CDD:238020	17/96 (18%)
		EGF_MSP1_1	372..407	CDD:403985	8/34 (24%)
		LamG	417..567	CDD:238058	38/179 (21%)
		EGF_CA	586..628	CDD:238011	17/88 (19%)
		LamG	654..791	CDD:238058	32/148 (22%)
		EGF_CA	814..846	CDD:238011	15/33 (45%)
		LamG	858..1007	CDD:238058	45/225 (20%)