DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18003 and CYB2

DIOPT Version :9

Sequence 1:	NP_001027401.1	Gene:	CG18003 / 3771779	FlyBaseID:	FBgn0061356	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_013658.1	Gene:	CYB2 / 854950	SGDID:	S000004518	Length:	591	Species:	Saccharomyces cerevisiae

Alignment Length:	360	Identity:	137/360 - (38%)
Similarity:	210/360 - (58%)	Gaps:	18/360 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVCVEDFEKKAVGQLEKNALDYYRSGAGEQFTLGLNREAFRRLRLRPRCLRDVSRLDISTKIFGE 67
            ::.:.|||..|...|.|.|..||.|||.::.|...|..|:.|:..:|:.|.||.::||||.:.|.
Yeast   202 IINLYDFEYLASQTLTKQAWAYYSSGANDEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGS 266

  Fly    68 QMQWPLGIAPTAMQKMAHP-DGEVGNARAAGKAGSIF--ILSTLSTTSLEDLAAGAPD--TIKWF 127
            .:..|..::.||:.|:.:| :||...||..|:..:..  ::|||::.|.|::...||.  .|:|:
Yeast   267 HVDVPFYVSATALCKLGNPLEGEKDVARGCGQGVTKVPQMISTLASCSPEEIIEAAPSDKQIQWY 331

  Fly   128 QLYIYKDRTITEKLVRRAEKANFKALVLTIDAPIFGHRRADVRNNFSLPSHLSLANFQGVKATGV 192
            |||:..||.||:.||:..||...|||.:|:|||..|.|..|::..||    .:.|..:.:|.|.|
Yeast   332 QLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFS----NTKAGPKAMKKTNV 392

  Fly   193 GNAAMGASGINEYVSSQFDPTITWKDIAWLKGITHLPIVVKGVLTAEDAVLAQEFGCAGLIVSNH 257
            ..    :.|.:..:|...||::|||||..||..|.||||:|||...||.:.|.|.|.:|:::|||
Yeast   393 EE----SQGASRALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVVLSNH 453

  Fly   258 GARQIDTVPASIEALPEIV-----KAVGDNLVVMLDGGIMQGNDIFKALALGAKTVFVGRPAVWG 317
            |.||:|...|.||.|.|.:     :.:.|.|.|.:|||:.:|.|:.|||.||||.|.:|||.::.
Yeast   454 GGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVLKALCLGAKGVGLGRPFLYA 518

  Fly   318 LAYNGQKGVEEMLSVLRKDFETTMALIGCQNLGDI 352
            .:..|:.|||:.:.:||.:.|.:|.|:|..::.::
Yeast   519 NSCYGRNGVEKAIEILRDEIEMSMRLLGVTSIAEL 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18003	NP_001027401.1	alpha_hydroxyacid_oxid_FMN	7..353	CDD:239203	137/356 (38%)
CG18003	NP_001027401.1	FMN_dh	17..359	CDD:279418	133/346 (38%)
CYB2	NP_013658.1	CYB5	34..187	CDD:227599
CYB2	NP_013658.1	FCB2_FMN	206..555	CDD:239238	137/356 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341320
Domainoid	1	1.000	229	1.000	Domainoid score	I418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I714
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54906
OrthoFinder	1	1.000	-	-		FOG0001123
OrthoInspector	1	1.000	-	-		oto99081
orthoMCL	1	0.900	-	-		OOG6_100930
Panther	1	1.100	-	-	O	PTHR10578
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1926
SonicParanoid	1	1.000	-	-		X693
TreeFam	0	0.000	Not matched by this tool.
	12	11.930