DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18003 and F41E6.5

DIOPT Version :9

Sequence 1:	NP_001027401.1	Gene:	CG18003 / 3771779	FlyBaseID:	FBgn0061356	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001122941.1	Gene:	F41E6.5 / 179241	WormBaseID:	WBGene00018286	Length:	371	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	172/369 - (46%)
Similarity:	240/369 - (65%)	Gaps:	11/369 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ALVCVEDFEKKAVGQLEKNALDYYRSGAGEQFTLGLNREAFRRLRLRPRCLRDVSRLDISTK-IF 65
            ||:.::|:.|.:...|.|.|.|||.|||.::.:|..|..||..|.:||||||.|..:|.|.. :.
Worm     5 ALLTLDDYRKFSEKNLVKLARDYYESGAEQEESLRRNISAFNNLLIRPRCLRSVENIDTSIDWLN 69

  Fly    66 GEQMQWPLGIAPTAMQKMAHPDGEVGNARAAGKAGSIFILSTLSTTSLEDLA-----AGAPDTIK 125
            |::..:|:||||||.||||..|||:...|.|..:.||.|.|:.||||:||:.     .||  ||
Worm    70 GKKSVFPVGIAPTAFQKMATLDGELSTVRGAAASNSIMICSSWSTTSVEDIGKEAKIVGA--TI- 131

  Fly   126 WFQLYIYKDRTITEKLVRRAEKANFKALVLTIDAPIFGHRRADVRNNFSLPSHLSLANFQGVKAT 190
            |||||:||||.|||.|:.|||.|..:|||||:|.|:.|.|..|..|.||||.||..|||:.....
Worm   132 WFQLYVYKDRAITESLIHRAEAAGVEALVLTVDTPVLGRRLKDTYNKFSLPKHLKFANFESNTQA 196

  Fly   191 GVGNAAMGASGINEYVSSQFDPTITWKDIAWLKGITHLPIVVKGVLTAEDAVLAQEFGCAGLIVS 255
            .:....:|.||..:|||||.||::.|..:.|::..|:||::||||:..:||:||.|.|..|:|||
Worm   197 EMPKGHVGESGFMQYVSSQIDPSLDWNTLKWIRTKTNLPVIVKGVMRGDDALLALEAGVDGIIVS 261

  Fly   256 NHGARQIDTVPASIEALPEIVKAVGDNLVVMLDGGIMQGNDIFKALALGAKTVFVGRPAVWGLAY 320
            |||.||:|...|:||:|||:::||.:.:.|.:|||:..|.||.||:||||:.||||||.:||||.
Worm   262 NHGGRQMDCTVATIESLPEVLRAVDNRIPVWMDGGVRNGRDILKAVALGARGVFVGRPVLWGLAT 326

  Fly   321 NGQKGVEEMLSVLRKDFETTMALIGCQNLGDITS--AMVVHESQ 362
            :|..||..:|.:|:.:|...:.|.|.:::.::.:  ..:||.|:
Worm   327 SGSAGVSAVLGLLQSEFYHALQLSGFRSIKELQNDKHAIVHCSK 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18003	NP_001027401.1	alpha_hydroxyacid_oxid_FMN	7..353	CDD:239203	167/351 (48%)
CG18003	NP_001027401.1	FMN_dh	17..359	CDD:279418	165/349 (47%)
F41E6.5	NP_001122941.1	FMN_dh	18..361	CDD:376451	165/345 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156073
Domainoid	1	1.000	317	1.000	Domainoid score	I679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6578
Inparanoid	1	1.050	325	1.000	Inparanoid score	I1465
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54906
OrthoDB	1	1.010	-	-		D500918at33208
OrthoFinder	1	1.000	-	-		FOG0001123
OrthoInspector	1	1.000	-	-		oto17315
orthoMCL	1	0.900	-	-		OOG6_100930
Panther	1	1.100	-	-	LDO	PTHR10578
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1926
SonicParanoid	1	1.000	-	-		X693
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940