DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Argl and ARG4

DIOPT Version :9

Sequence 1:	NP_001027234.1	Gene:	Argl / 3771738	FlyBaseID:	FBgn0032076	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_011882.1	Gene:	ARG4 / 856411	SGDID:	S000001060	Length:	463	Species:	Saccharomyces cerevisiae

Alignment Length:	453	Identity:	217/453 - (47%)
Similarity:	304/453 - (67%)	Gaps:	3/453 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KMWGGRFTEGPHEALHSLNNSLPYDSRLYADDLDASKAYAEALHRAGLINSAEADKLVKNLELLR 74
            |:||||||......:|..|.|||||.::|..||:.:|.|...|.:.||:...|..|:.:.|..::
Yeast     7 KLWGGRFTGETDPLMHLYNASLPYDYKMYKADLEGTKVYTAGLQKLGLLTETELAKIHEGLAEIK 71

  Fly    75 FDWIEGTVKILPGDEDVHTVNERLLVEITG-ELGQRLHTGRSRNDQVVTDMKLWLRKAIRETL-G 137
            .:|........|.|||:||.|||.|.|:.| ::..::|||||||||||||::::.|..:.:|| .
Yeast    72 KEWDADKFVRHPNDEDIHTANERRLGELIGRDIAGKVHTGRSRNDQVVTDLRIYCRDIVNDTLFP 136

  Fly   138 RLSGIIETATRQAELHLGVLMPGYTHLQRAQTVQFSHWLLSHAFALREDGQRLLELRDRANVLPL 202
            .|.|::|...::||..:.|||||||||||||.:::||||.|:|....||.:||.::..|.|..||
Yeast   137 ALKGLVEVLIKRAEGEIDVLMPGYTHLQRAQPIRWSHWLSSYATYFTEDYKRLGQILHRLNQSPL 201

  Fly   203 GSGALAGNPLGIDRLWLAERLGFSGVTANSMHAVGDRDFVVDFIYCCSMVSLHLSRLAEDLIIYS 267
            |:|||||:|.||||.:|||.|||:.|..||:.||.||||:|:.::..::...|:||.|||||||.
Yeast   202 GAGALAGHPYGIDREFLAEGLGFNSVIGNSLVAVSDRDFIVELMFWGTLFMNHISRFAEDLIIYC 266

  Fly   268 TKEFDFIKLADGFSSGSSLMPQKRNPDSLELIRGMAGVITANLTGIMMTIKGTPSTYNKDLQYDK 332
            |.||.||:|:|.:|:||||||||:|.|||||:||.:|.:..:|||.:|::||.||||:||:|.||
Yeast   267 TAEFGFIQLSDAYSTGSSLMPQKKNADSLELLRGKSGRVFGDLTGFLMSLKGIPSTYDKDMQEDK 331

  Fly   333 QFCFQSFDKLSQVLEVTDGVLQTIQVKQESMEAALSTDMLATDWAYYLVKKGVPFRQAHHIIGRV 397
            :..|.....:...:.:..||:.|:.|.:|.|||||:.||||||.|.|||:||||||:.|||.|..
Yeast   332 EPLFDCLTTVEHSMLIATGVISTLTVNKEKMEAALTMDMLATDLADYLVRKGVPFRETHHISGEC 396

  Fly   398 VSEAEKRGVD-ITDLPLGDLQKFSPLFGSDIVAVADYSNNVQQYNAIGGTASSSIVEQLRLLK 459
            |:.||:.|:. |..|.|...||....||.|:....::..:|::.:|.||||.|::::||..||
Yeast   397 VATAERLGLSGIDKLTLEQYQKIDSRFGQDLFETFNFEQSVERRDATGGTAKSAVLKQLDNLK 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Argl	NP_001027234.1	PRK00855	9..460	CDD:179143	217/453 (48%)
Argl	NP_001027234.1	Argininosuccinate_lyase	30..461	CDD:176463	208/433 (48%)
ARG4	NP_011882.1	argH	8..463	CDD:129918	216/452 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346585
Domainoid	1	1.000	282	1.000	Domainoid score	I256
eggNOG	1	0.900	-	-		E1_COG0165
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32
Inparanoid	1	1.050	421	1.000	Inparanoid score	I286
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60692
OrthoFinder	1	1.000	-	-		FOG0003623
OrthoInspector	1	1.000	-	-		oto99323
orthoMCL	1	0.900	-	-		OOG6_101588
Panther	1	1.100	-	-	LDO	PTHR43814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R80
SonicParanoid	1	1.000	-	-		X2496
TreeFam	1	0.960	-	-
	15	14.790