DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Argl and ASL

DIOPT Version :9

Sequence 1:	NP_001027234.1	Gene:	Argl / 3771738	FlyBaseID:	FBgn0032076	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_000039.2	Gene:	ASL / 435	HGNCID:	746	Length:	464	Species:	Homo sapiens

Alignment Length:	450	Identity:	239/450 - (53%)
Similarity:	314/450 - (69%)	Gaps:	0/450 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KMWGGRFTEGPHEALHSLNNSLPYDSRLYADDLDASKAYAEALHRAGLINSAEADKLVKNLELLR 74
            |:|||||.......:...|.|:.||..|:..|:..||||:..|.:|||:..||.|:::..|:.:.
Human     7 KLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVA 71

  Fly    75 FDWIEGTVKILPGDEDVHTVNERLLVEITGELGQRLHTGRSRNDQVVTDMKLWLRKAIRETLGRL 139
            .:|.:||.|:...|||:||.|||.|.|:.|....:||||||||||||||::||:|:......|.|
Human    72 EEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLL 136

  Fly   140 SGIIETATRQAELHLGVLMPGYTHLQRAQTVQFSHWLLSHAFALREDGQRLLELRDRANVLPLGS 204
            ..:|.|...:||....||.||||||||||.:::|||:||||.||..|.:||||:|.|.|||||||
Human   137 WELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGS 201

  Fly   205 GALAGNPLGIDRLWLAERLGFSGVTANSMHAVGDRDFVVDFIYCCSMVSLHLSRLAEDLIIYSTK 269
            ||:||||||:||..|...|.|..:|.|||.|..:||||.:|::..|:...||||:|||||:|.||
Human   202 GAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTK 266

  Fly   270 EFDFIKLADGFSSGSSLMPQKRNPDSLELIRGMAGVITANLTGIMMTIKGTPSTYNKDLQYDKQF 334
            ||.|::|:|.:|:||||||||:|||||||||..||.:.....|::||:||.|||||||||.||:.
Human   267 EFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEA 331

  Fly   335 CFQSFDKLSQVLEVTDGVLQTIQVKQESMEAALSTDMLATDWAYYLVKKGVPFRQAHHIIGRVVS 399
            .|:..|.:|.||:|..||:.|:|:.||:|..|||.||||||.|||||:||:||||||...|:.|.
Human   332 VFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVF 396

  Fly   400 EAEKRGVDITDLPLGDLQKFSPLFGSDIVAVADYSNNVQQYNAIGGTASSSIVEQLRLLK 459
            .||.:||.:..|.|.:||..||||..|::.|.||.::|:||.|:||||.||:..|:|.::
Human   397 MAETKGVALNQLSLQELQTISPLFSGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Argl	NP_001027234.1	PRK00855	9..460	CDD:179143	239/449 (53%)
Argl	NP_001027234.1	Argininosuccinate_lyase	30..461	CDD:176463	232/429 (54%)
ASL	NP_000039.2	PLN02646	1..463	CDD:215348	239/449 (53%)
ASL	NP_000039.2	Argininosuccinate_lyase	27..459	CDD:176463	232/429 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159909
Domainoid	1	1.000	317	1.000	Domainoid score	I1265
eggNOG	1	0.900	-	-		E1_COG0165
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1432
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60692
OrthoDB	1	1.010	-	-		D1074729at2759
OrthoFinder	1	1.000	-	-		FOG0003623
OrthoInspector	1	1.000	-	-		oto89271
orthoMCL	1	0.900	-	-		OOG6_101588
Panther	1	1.100	-	-	LDO	PTHR43814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R80
SonicParanoid	1	1.000	-	-		X2496
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800