Protein Alignment SkpF and SKP1

DIOPT Version :10

• Sequence 1: NP_611796.1
• Gene: SkpF / 37713
• FlyBaseID: FBgn0034863
• Length: 171
• Species: Drosophila melanogaster
• Sequence 2: NP_733779.1
• Gene: SKP1 / 6500
• HGNCID: 10899
• Length: 163
• Species: Homo sapiens
• Alignment Length: 166
• Identity: 95/166 - (57%)
• Similarity: 119/166 - (71%)
• Gaps: 9/166 - (5%)

  Fly     1 MPVIKLQSSDGEIFETDIETAKCSSTIKTLLEDCPVEAE-NDTLIPLPNVNSTILKKVLIWAKHH 64
            ||.||||||||||||.|:|.||.|.||||:|||..::.| :|..:||||||:.|||||:.|..||
Human     1 MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHH 65

  Fly    65 REDIA----EENEEEAAKSVAVQITPWDAEFLSMDQGTLFELILAANYLDIPNLLNAACMTVANM 125
            ::|..    :||:|:....:.|    ||.|||.:|||||||||||||||||..||:..|.|||||
Human    66 KDDPPPPEDDENKEKRTDDIPV----WDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANM 126

  Fly   126 IKGRTTEEIRQTFHITNDFSPSEEDLMTMESEVPQE 161
            |||:|.||||:||:|.|||:..||..:..|::..:|
Human   127 IKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEE 162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SkpF	NP_611796.1	BTB_POZ_SKP1	3..126	CDD:349631	74/127 (58%)
		Skp1	112..157	CDD:460222	25/44 (57%)
SKP1	NP_733779.1	BTB_POZ_SKP1	4..127	CDD:349631	74/126 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..83		6/19 (32%)
		Interaction with the F-box domain of F-box proteins. /evidence=ECO:0000269|PubMed:35982156, ECO:0007744|PDB:7Z8B	104..163		35/59 (59%)
		Skp1	113..160	CDD:460222	25/46 (54%)