DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3520 and FOCAD

DIOPT Version :9

Sequence 1:	NP_611792.1	Gene:	CG3520 / 37708	FlyBaseID:	FBgn0034859	Length:	1204	Species:	Drosophila melanogaster
Sequence 2:	XP_016870341.1	Gene:	FOCAD / 54914	HGNCID:	23377	Length:	1828	Species:	Homo sapiens

Alignment Length:	1344	Identity:	279/1344 - (20%)
Similarity:	481/1344 - (35%)	Gaps:	343/1344 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SSVVKLASCLEKIYNKVVESREKQLPEHQIKEIEFLKAQCKHDHMQLSLMSCQTLVRLVDEGVLE 75
            ::|:|.....|||:...          :|...:..|..:|..|::.:....|:.||.||.:...|
Human    53 AAVLKENGFSEKIHQST----------NQTPALNLLWEKCCSDNVVVRTACCEGLVALVAQDHAE 107

  Fly    76 ANGVQNSLLSMLANAGPMHFAIITESILGMQLLSLKRRTSSLKGQESYQCTYGLKTQQHPLISLL 140
            .:.|.|.:|:::.:....|..|  ::|  |.||.::.......|:::.|..|.::...||||::|
Human   108 FSYVLNGILNLIPSTRNTHGLI--KAI--MHLLQMQALKEGQGGEKNIQSIYTIRNHPHPLITVL 168

  Fly   141 QHSSANMHDVANKIIGICQHYDKSIRDYSIEYLRPVFLYVLCNPQTLHDVKPIWTCLLNLSGKQP 205
            :|..........::....|...:.:....|:.:.|...|:.|.|..|.:...:...||.:. .||
Human   169 EHRPDCWPVFLQQLTAFFQQCPERLEVSCIQIMAPFLWYLYCEPSQLQEYAKLRLALLKVL-LQP 232

  Fly   206 EA-------RALMQELLAWSKFNNANTCLCTSILVIEAIDHFLQREDHAQSID--LGIYQAC--L 259
            :.       ..|.|::|.          ||..|:..      ||.:|..|:.:  :.|.:.|  |
Human   233 QVLCDKDQPSILEQQILQ----------LCCDIVPC------LQVKDLIQTTEAMMFIEEVCLSL 281

  Fly   260 IKQLANYGID-PRPSLQCL----------------LRVLHATREQTKDHYHVLLVLLADVLHVLS 307
            ::....:.|. .:.|||.|                :.:|..:.|..|:.:.|.||::.
Human   282 LRHPVFWKIQLTQMSLQLLCVSEVSLKITGECSSSIHLLEHSVELLKEDFPVELVIIG------- 339

  Fly   308 PFYLADLLRIIVFVVVQERCGHEY-ILNMCLD-------------------GIIQWMSQTAF--- 349
                      |..:::|.....:. |||:.|.                   .|:|.:|.||.
Human   340 ----------IALLLLQTPASQQKPILNLALKLLSVTEDQKIPKSSLLLVMPILQILSSTALEDC 394

  Fly   350 --IPAEGLA---LAHQIVEKVLDPERSDQEAEVISTKQLKPAHMRNYHPDIAIAFDLATLVESFD 409
              :..||.:   ||..::| ::..|....:.:.:|.|.:.|  :.:.:..|..|:.:..::.  |
Human   395 ISVDEEGPSRQQLALNLLE-MIQQECYRDDHQKLSYKLVCP--VTSMYGTIFTAWRILEVMT--D 454

  Fly   410 ASDNQDVFAFVDALNVKANTVFCQRLHLFLRALFLSKKPPVDCWFKIYEVILQIVKVNEGIAY-- 472
            :|...|..|.|::| :....|......|.|..|.:..|.         :.:.||:||...:|.
Human   455 SSAASDWLASVESL-LPITAVIPAPAFLLLAHLLVEDKG---------QNLHQILKVTTELAQAD 509

  Fly   473 -----DFLMTYIFKLAHENNPELQLELLRGLASFAVCKDNVPMILNTIRNLSTENGTFCVD--LY 530
                 :.:...:|||.....|.|..::|..|....|.|..:..||..|:.|.|......|.  |.
Human   510 SSQVPNLIPVLMFKLGRPLEPILYNDILYTLPKLGVHKVCIGQILRIIQLLGTTPRLRAVTLRLL 574

  Fly   531 VRLWRVERRTYPFLLKQIA-QPLPD----NDKRWELQIARNHAMREICQEKPTLHGTELLPHLSN 590
            ..||..:.|.||.|.:.:| ..:|.    .:.:||..||:..::|:||:::|..||.::|..:|.
Human   575 TSLWEKQDRVYPELQRFMAVSDVPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQ 639

  Fly   591 TLNHSSDEAGDLATSLALDAIYSLCDSHTVNIASTWQALGSKFRNEMRPQTLKSLYRLFGLVPML 655
            .||..:........:|.|..:::||.:..|.|.|||.||..|...:.||..||:|..||.|||.|
Human   640 VLNECTKPDQATPAALVLQGLHALCQAEVVCIRSTWNALSPKLSCDTRPLILKTLSELFSLVPSL 704

  Fly   656 KTPTLEYEKLADDALEHLWQAISRPGTDAAQVRNALVALRNYEPGVTLNLRHIPAQFRFEI---- 716
            ...|.|||......|..||  ......|......|..:|.|:..| ...:.|:|.:.|.||
Human   705 TVNTTEYENFKVQVLSFLW--THTQNKDPIVANAAYRSLANFSAG-EHTILHLPEKIRPEIPIPE 766

  Fly   717 -------VGGGVGAGGAGGREVVDLQQETVPGEVWVQLLQKIRPECGDAAADLISHHIDSEINAF 774
                   |            |.|||   :|||..:::||....|....|..:..:..:..|:...
Human   767 ELDDDEDV------------EDVDL---SVPGSCYLKLLSLTPPLVLPALEEFFTSLVKQEMVNM 816

  Fly   775 RSGVY--------RLPEGKPE---PRKLVGLFATSPLRAVTNYLVSQARFGDYVPEPYAVTFALR 828
            ..|:|        |..:||..   |..::.::.|:....:...|.....|
Human   817 PRGIYHSALKGGARSDQGKTVAGIPNFILKMYETNKQPGLKPGLAGGMLF--------------- 866

  Fly   829 SLSKNFPKPIPPLDWSCLTSFFHLSFDARKYCIIIAKNQAVNSGTAKRLLENF---LIDFEPNCF 890
                            |.....:.|.|.:....::|........|:..|:...   |.::....|
Human   867 ----------------CYDVSMYQSKDGKPLNRLMASRGRSFKQTSLALVHEVHIQLSEWHRAIF 915

  Fly   891 EEDLLLLF------SLLPEIANSVSLQILKNFAEKVAVYCFKESQINDFVEGCLFEKFLESV--- 946
            .....|.:      ::|......:.|| ||:..|:.....:|:|....:|...|.::..::.
Human   916 LPQAWLAYMNRAYHAILQGRLGELELQ-LKHGKEEPEEVQYKKSTAWLWVRDMLTDEITKAAAKE 979

  Fly   947 KYIFTGNCDIPEVLDVFTLIVERYMDSMNLDSRLFERYTEVVATLHPNAIDGLTTPANWWETPVG 1011
            ..:..||..:  .|....::|.|:..|::.||                  |||.
Human   980 SPVVKGNALL--ALSSLAVVVSRHEASLSSDS------------------DGLL----------- 1013

  Fly  1012 KLKKATIIRCYLVLYNEKLPNPL---KWLTPIIDA--------YEKRAEERPFFYRHLAATLYAF 1065
                            |..||.|   :|::.::|.        |:.|.:...:||       |..
Human  1014 ----------------EVQPNFLSMKEWVSMVLDTLLVIVDSHYQPRGQLLSWFY-------YKS 1055

  Fly  1066 ESDEHSSNWIAE----MFLEIQMLLAEASNKEKVNRALYLLDIFI---------LAVDVLSGCA- 1116
            .|.|::::.||.    ..|.:.:.:...|.||||...|.:|...:         .||.:..|.|
Human  1056 YSGENTASAIARSAAATALSLLVPVFIISCKEKVEEILNMLTARLPGKPSADESQAVQIHMGLAL 1120

  Fly  1117 ----------------------VLLGSVDVVATDDKQRLALFPESLQY-------------LCDH 1146
                                  :|:.|:|.:..      ..|..||:|             |..|
Human  1121 GMFLSRLCEEKLSDISGQEMNLLLMKSLDALEN------CCFDTSLEYNTGCILGVGLVLSLMSH 1179

  Fly  1147 VFWKDQEAKIYEFLFNLYKHTTMPASYADVFREAI------ICS 1184
            .........:...|..|..|.....|.:..|:|.:      :|:
Human  1180 SSQMQSRVHVAALLRKLSAHVDDSGSQSRTFQEVLAYTLSCVCT 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3520	NP_611792.1	DUF3730	475..694	CDD:289307	70/225 (31%)
CG3520	NP_611792.1	DUF3028	<798..1201	CDD:288127	75/465 (16%)
FOCAD	XP_016870341.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147998
Domainoid	1	1.000	103	1.000	Domainoid score	I6820
eggNOG	1	0.900	-	-		E1_2C769
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I4002
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D104158at33208
OrthoFinder	1	1.000	-	-		FOG0007517
OrthoInspector	1	1.000	-	-		oto89697
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16212
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8028
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.980