DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3530 and MTMR2

DIOPT Version :9

Sequence 1:NP_726322.1 Gene:CG3530 / 37707 FlyBaseID:FBgn0028497 Length:761 Species:Drosophila melanogaster
Sequence 2:NP_057240.3 Gene:MTMR2 / 8898 HGNCID:7450 Length:643 Species:Homo sapiens


Alignment Length:632 Identity:228/632 - (36%)
Similarity:346/632 - (54%) Gaps:67/632 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 TSALRLSFDNISPETEEPPDGNKRLWGVPVPPFVSEKVVSWIEEEFNEAPVFYNGNSVLKKVENV 84
            :.::..|.||.||:.....:.||          ::|.          |.|....|.::....::|
Human    47 SDSISTSADNFSPDLRVLRESNK----------LAEM----------EEPPLLPGENIKDMAKDV 91

  Fly    85 RMIDRYNTKNPTVGTLYLTATHLIF--VEPDSNKETWILHMHVASIEKLP----LSTTGS---PL 140
            ..|..:.  ....|||.:|...|.|  :|.|   ..::|...:..|.::.    .|:.|.   .|
Human    92 TYICPFT--GAVRGTLTVTNYRLYFKSMERD---PPFVLDASLGVINRVEKIGGASSRGENSYGL 151

  Fly   141 LIRCKTFLSVTFV-IPKDSECHDVYTSLLKLFQPVSIN-KLYCFNYQPNKDDFPKNAGWDYFKLE 203
            ...||...::.|. .|:......::.:|:|...|||.| .|:.|.|   |:.||:| ||..:...
Human   152 ETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEY---KEVFPEN-GWKLYDPL 212

  Fly   204 AEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NN 267
            .|::...:|||:|.:..:||:||||||||..:.||.......|...:.|||:||:|||:::| .:
Human   213 LEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPES 277

  Fly   268 KASICRCSQPLSGFSA-RCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAF 331
            :|:|.|||||:.|.|. |..|||:.|:||..:|:.:..:::.|.||.:||:||:|.|.|||:|..
Human   278 QATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDA 342

  Fly   332 YENIKFHFLGIENIHVQRASLQKVLEACEQKSPTM--SAFINALESSGWLKHIRSILDTSSFIAN 394
            |:|.:..||.|.||||.|.||:|:.|..   .|.:  :.:::.|||:.||:||:.||..:..||:
Human   343 YQNAELVFLDIHNIHVMRESLRKLKEIV---YPNIEETHWLSNLESTHWLEHIKLILAGALRIAD 404

  Fly   395 AVDKG-VSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGH--- 455
            .|:.| .|||||||||||||||:.|||.|||:.|||||:||:.|:||:||:|||:|..|.||   
Human   405 KVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDK 469

  Fly   456 IQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKL 520
            ...|| :.||:|.||:||.||:..|...||||||.||:.:.||::||.||||:.|.|:.|....|
Human   470 NHADA-DRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENL 533

  Fly   521 AERTFSLWGYMANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSRFESGIHPREPL----G 581
            .:||.|||.|:.:.|.::.||||....:..:....:.:.::.|.|.|.|:...:.|:||:    .
Human   534 PKRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYK 598

  Fly   582 DVLLDSKEHCNSLEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGK 628
            ::|....|           |.|::...:..||..:....:..|:|.:
Human   599 ELLAKRAE-----------LQKKVEELQREISNRSTSSSERASSPAQ 634

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG3530NP_726322.1 PH-GRAM_MTMR6-like 78..173 CDD:270030 21/104 (20%)
Myotub-related 179..514 CDD:284109 164/342 (48%)
FYVE_MTMR_unchar 693..753 CDD:277277
MTMR2NP_057240.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56 1/8 (13%)
PH-like 73..187 CDD:388408 25/128 (20%)
Myotub-related 192..528 CDD:368997 164/343 (48%)
Substrate binding. /evidence=ECO:0000269|PubMed:14690594 330..333 1/2 (50%)