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Protein Alignment CG3530 and MTMR3

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_066576.1	Gene:	MTMR3 / 8897	HGNCID:	7451	Length:	1198	Species:	Homo sapiens

Alignment Length:	679	Identity:	204/679 - (30%)
Similarity:	308/679 - (45%)	Gaps:	133/679 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VEPDSNKETWILHMH------VASIEKLPLSTTGSPLLIRCK-TFLSVTFVIPKDSECHDVYTSL 167
            :..|.|.:...|.:|      |...|...::.:...|.|:.| :.::|...:.:..||.|::...
Human    24 IREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLH 88

  Fly   168 L------------KLFQ---------------PVSINKLYCFNYQ--------PNKDDF-----P 192
            |            ..|:               |..|..|:.|.|.        ..|:..     |
Human    89 LTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRP 153

  Fly   193 KNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGR 257
            .......||.|.| :.....|.||.:.::||||:||.:||:::.||...|...|.|.|.|||..|
Human   154 GEHVTSRFKNEVE-RMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKR 217

  Fly   258 LPVLTYLH-NNKASICRCSQP-LSGFSARCLEDEQMLEAIRKT---------------NSNTDY- 304
            :|.:.|.| :|.|.|.||.|| :|.:..|..:||.:::::.|.               |::.|:
Human   218 IPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFP 282

  Fly   305 -----------------------------MYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFL 340
                                         :.::|.|....|:||||.|.|.|...:|.|.:..|:
Human   283 NGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFM 347

  Fly   341 GIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGV-SVVV 404
            |:.|||..|.|.|.:...|.| .|....:::||||:.||.|:..:|.::..:.:|||:.. .|:|
Human   348 GMANIHSIRRSFQSLRLLCTQ-MPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLV 411

  Fly   405 HCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQT--DAREVSPIF 467
            |||||||||.|:.:||:|:|:||||||:|||.|:|.:||.|||||::||||.:.  |..|..|:|
Human   412 HCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVF 476

  Fly   468 TQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMA 532
            .|:|||..||..|...:|||||.||:.|..|.:||.||||:.|..|:|.:....|||.|:|..:.
Human   477 LQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLR 541

  Fly   533 NHLNEYINPLYKPNVDEAIKANLAPQC----IKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNS 593
            .....:.|.||. :..||:   |.|.|    :..|..:|....|   |..|:.|..........|
Human   542 AGNKAFKNLLYS-SQSEAV---LYPVCHVRNLMLWSAVYLPCPS---PTTPVDDSCAPYPAPGTS 599

  Fly   594 LEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGKV---NKELSSNEINDNKYNYDKKLSELS-- 653
            .:|.......:..|:.|.          .|:....|   ::..|...:|: |:...::..|||
Human   600 PDDPPLSRLPKTRSYDNL----------TTACDNTVPLASRRCSDPSLNE-KWQEHRRSLELSSL 653

  Fly   654 AADDDHPLKASNM-------SFASLSLSA 675
            |...:.||.|.::       ..|.||::|
Human   654 AGPGEDPLSADSLGKPTRVPGGAELSVAA 682

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.