DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and MTMR1

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_005274822.1	Gene:	MTMR1 / 8776	HGNCID:	7449	Length:	699	Species:	Homo sapiens

Alignment Length:	656	Identity:	223/656 - (33%)
Similarity:	343/656 - (52%)	Gaps:	82/656 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SPETEEPPDGN-----KRLWGVPVPPFVSEKVVS-------------------------WIEEEF 65
            |.||.:.|.|:     |:|....:...:|..|.|                         .|:||.
Human    43 SVETLDSPTGSHVEWCKQLIAATISSQISGSVTSENVSRDYKVFRRPDLRNIHKARQRLEIQEEH 107

  Fly    66 N----------------------EAPVFYNGNSVLKKVENVRMIDRYNTKNPTVGTLYLTATHLI 108
            |                      |||:| .|.|:...|::|..|..:  .....|||.:|...|.
Human   108 NGYPSEAEADQALRDGNKLAQMEEAPLF-PGESIKAIVKDVMYICPF--MGAVSGTLTVTDFKLY 169

  Fly   109 F--VEPDSNKETWILHMH---VASIEKLPLSTTGS---PLLIRCKTFLSVTFVIPKDSECH-DVY 164
            |  ||.|.:   :||.:.   ::.:||:...:.|.   .:.|.||...::.....::.:.. .::
Human   170 FKNVERDPH---FILDVPLGVISRVEKIGAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQSKLGIF 231

  Fly   165 TSLLKLFQPVSINK-LYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELC 228
            .:|.|...|:|..: |:.|:|   |:.||.| ||..:...:|:|...:|||:|.:..:|..||.|
Human   232 ENLNKHAFPLSNGQALFAFSY---KEKFPIN-GWKVYDPVSEYKRQGLPNESWKISKINSNYEFC 292

  Fly   229 DTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASICRCSQPLSG-FSARCLEDEQM 291
            ||||..|.||.......|...:.||:|||:|||:::| .::|:|.||||||.| ...||.|||:.
Human   293 DTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKY 357

  Fly   292 LEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVL 356
            |:.|...|:.:..:.:.|.|....|..|:..|.|||:|:.|.|.:..||.|.||||.|.||:|:.
Human   358 LQTIMDANAQSHKLIIFDARQNSVADTNKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLK 422

  Fly   357 EACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKG-VSVVVHCSDGWDRTAQVCSLA 420
            |.. ..|...:.:::.::.:.||::||.:|..:..||:.::.| .|||||||||||||||:.|||
Human   423 EIV-YPSIDEARWLSNVDGTHWLEYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLA 486

  Fly   421 QLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGH---IQTDAREVSPIFTQFLDCTWQLMSQRS 482
            .|||:.||||||||:.|:||:|::|||:|:.|.||   ...|| :.||||.||:||.||:..|..
Human   487 MLMLDSYYRTIKGFETLVEKEWISFGHRFALRVGHGNDNHADA-DRSPIFLQFVDCVWQMTRQFP 550

  Fly   483 EAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYKPNV 547
            .||||||.||:.:.||::||.||||:.|||:.|....:..:|.|||.|:.:.|:|:.||.:....
Human   551 SAFEFNELFLITILDHLYSCLFGTFLCNCEQQRFKEDVYTKTISLWSYINSQLDEFSNPFFVNYE 615

  Fly   548 DEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNSLEDHVQHLTKRIASFKNYI 612
            :..:....:...::.|...|.|:...:.|:.|:...|.:.......|:..|:.|.:.:|:  ..:
Human   616 NHVLYPVASLSHLELWVNYYVRWNPRMRPQMPIHQNLKELLAVRAELQKRVEGLQREVAT--RAV 678

  Fly   613 SKSAKK 618
            |.|:::
Human   679 SSSSER 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	22/103 (21%)
		Myotub-related	179..514	CDD:284109	157/340 (46%)
		FYVE_MTMR_unchar	693..753	CDD:277277
MTMR1	XP_005274822.1	PH-GRAM_MTMR1	141..240	CDD:270165	22/103 (21%)
MTMR1	XP_005274822.1	Myotub-related	247..582	CDD:284109	157/340 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1956
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.880