Protein Alignment Mtmr6 and Sbf2

DIOPT Version :10

• Sequence 1: NP_726322.1
• Gene: Mtmr6 / 37707
• FlyBaseID: FBgn0028497
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: XP_008758019.1
• Gene: Sbf2 / 691042
• RGDID: 1588657
• Length: 1904
• Species: Rattus norvegicus
• Alignment Length: 819
• Identity: 189/819 - (23%)
• Similarity: 297/819 - (36%)
• Gaps: 274/819 - (33%)

  Fly    96 TVGTLYL----TATHLIFVEPDSNKETWILH--MHVASIEKLPLSTTGSPLLIRCKTFLSVTFVI 154
            |:|..||    |.|   .||..:|:..|...  :.|:...:||.|||
  Rat  1052 TIGRQYLLKKRTGT---IVEERANRPGWNEEDDISVSDDCELPTSTT------------------ 1095

  Fly   155 PKDSECHDVYTSLLKLFQPVSINKLY---CF-NYQ---------PNKDDFPKNAGWDYFKLEAEF 206
                         ||..:..::.:|.   || :||         .:....|     :||::.|.
  Rat  1096 -------------LKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSKP-----EYFRVTAS- 1141

  Fly   207 KHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHNNKASI 271
                           |..|.||.:||..:.:|:......|...:|.....||||:.:.::...::
  Rat  1142 ---------------NRLYSLCRSYPGLLVIPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTL 1191

  Fly   272 CRCSQPLSGF------------------------SARCLEDEQMLEAI----------------- 295
            ...|   .||                        |:..:|.|:.|:|:
  Rat  1192 LLRS---GGFHGKGVVGLFKSQNSPQAVSTSSLESSSSIEQEKYLQALLTAVIVHQKLRGNSTLT 1253

  Fly   296 -------------RKTNSNTDYMYVV----DTRPRINAMAN------------------------ 319
                         |.:..:|....||    |..|. |:.|.
  Rat  1254 VRPTLALSPGTERRSSRMSTVLKQVVPGHLDVNPS-NSFARGVHGYRDKCFTQSNSKSSAKEPVH 1317

  Fly   320 --------------------------RAAGK----GYENEAFYEN-------------------- 334
                                      |.|||    .:.|..:.:|
  Rat  1318 NQGVWASLRSSTRLISSPTSLIDVGARLAGKDHSASFSNSTYLQNQLSKRQAALYIFGEKSQLRS 1382

  Fly   335 --IKF----HFLGIE--NIHVQRASLQKVLEACEQKS-PTMS--AFINALESSGWLKHIRSILDT 388
              ::|    .|:.:|  .|...:||.:|::.||...: ||.|  .|:.|||.|.|...:..|:..
  Rat  1383 SKVEFAFNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALEDSEWFPQLHRIMQL 1447

  Fly   389 SSFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERC 453
            :..::..::.|.||.|...:|||.|.||.||.||:.:|:||||:||:.|:||:||:||||||:|.
  Rat  1448 AVVVSEVLENGSSVWVCLEEGWDITTQVTSLVQLLSDPFYRTIEGFRMLVEKEWLSFGHKFSQRS 1512

  Fly   454 G-HIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLD 517
            . .:.:.....:|||.|||||..|:.:|....||||..:|..|..|..|.:|.||:.:.:.:||:
  Rat  1513 SLALNSQGSGFAPIFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLE 1577

  Fly   518 L---------KLAERTFSLW---GYMANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSR- 569
            .         |.|::...:|   ..|......:.|.||.|...||:|.|:....:|.| ..|:.
  Rat  1578 HGTLFDDKGDKHAKKGVCIWECIDKMHKRSPVFFNYLYSPVEIEALKPNVNVSSLKKW-DYYTEE 1641

  Fly   570 -FESGIHPREPLGDVLLDSKEHCNSLEDHVQ----HLTKRIASFKNYISKSAKKLQDAT-SAPGK 628
             ..:|     |..|.::.:.:|....|..|.    ..::|...:..|        .|.| |.|..
  Rat  1642 TLSAG-----PSYDWMMLTPKHFPYEESDVAGGAGPQSQRKTVWPCY--------DDVTCSQPDA 1693

  Fly   629 VNKELSSNEINDNKYN---------YDKKLSELSAAD-DDHPLKASNMS--FASLSLSAEQSSPP 681
            :.:..|..|..::|.|         ::|...:|.... .||.|:.|:.|  .||.::.:.|..|.
  Rat  1694 LTRLFSEIEKLEHKLNQTPEKWHQLWEKITMDLKEEPRTDHSLRHSSRSPGIASTNVPSYQKRPA 1758

  Fly   682 -QAL---PEEINSVAVDWKPMRNVTTCSCSTPFDQFSKK 716
             .||   |.|..|...  .|...|.. ..:|.:.|::.|
  Rat  1759 LHALHRSPTEDQSTTT--APSNGVEH-RAATLYSQYTSK 1794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtmr6	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	18/82 (22%)
		PTP-MTMR6-like	202..501	CDD:350380	105/442 (24%)
		FYVE_MTMR_unchar	693..753	CDD:277277	5/24 (21%)
Sbf2	XP_008758019.1	uDENN	1..86	CDD:214824
		DENN	115..297	CDD:460461
		dDENN	351..419	CDD:129037
		SBF2	529..752	CDD:463536
		PH-GRAM_MTMR13	880..998	CDD:275416
		PTP_DSP_cys	1136..1540	CDD:475123	98/423 (23%)
		PH_Sbf1_hMTMR5	1797..1902	CDD:269941