DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and Sbf2

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_008758019.1	Gene:	Sbf2 / 691042	RGDID:	1588657	Length:	1904	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	189/819 - (23%)
Similarity:	297/819 - (36%)	Gaps:	274/819 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 TVGTLYL----TATHLIFVEPDSNKETWILH--MHVASIEKLPLSTTGSPLLIRCKTFLSVTFVI 154
            |:|..||    |.|   .||..:|:..|...  :.|:...:||.|||
  Rat  1052 TIGRQYLLKKRTGT---IVEERANRPGWNEEDDISVSDDCELPTSTT------------------ 1095

  Fly   155 PKDSECHDVYTSLLKLFQPVSINKLY---CF-NYQ---------PNKDDFPKNAGWDYFKLEAEF 206
                         ||..:..::.:|.   || :||         .:....|     :||::.|.
  Rat  1096 -------------LKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSKP-----EYFRVTAS- 1141

  Fly   207 KHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHNNKASI 271
                           |..|.||.:||..:.:|:......|...:|.....||||:.:.::...::
  Rat  1142 ---------------NRLYSLCRSYPGLLVIPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTL 1191

  Fly   272 CRCSQPLSGF------------------------SARCLEDEQMLEAI----------------- 295
            ...|   .||                        |:..:|.|:.|:|:
  Rat  1192 LLRS---GGFHGKGVVGLFKSQNSPQAVSTSSLESSSSIEQEKYLQALLTAVIVHQKLRGNSTLT 1253

  Fly   296 -------------RKTNSNTDYMYVV----DTRPRINAMAN------------------------ 319
                         |.:..:|....||    |..|. |:.|.
  Rat  1254 VRPTLALSPGTERRSSRMSTVLKQVVPGHLDVNPS-NSFARGVHGYRDKCFTQSNSKSSAKEPVH 1317

  Fly   320 --------------------------RAAGK----GYENEAFYEN-------------------- 334
                                      |.|||    .:.|..:.:|
  Rat  1318 NQGVWASLRSSTRLISSPTSLIDVGARLAGKDHSASFSNSTYLQNQLSKRQAALYIFGEKSQLRS 1382

  Fly   335 --IKF----HFLGIE--NIHVQRASLQKVLEACEQKS-PTMS--AFINALESSGWLKHIRSILDT 388
              ::|    .|:.:|  .|...:||.:|::.||...: ||.|  .|:.|||.|.|...:..|:..
  Rat  1383 SKVEFAFNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALEDSEWFPQLHRIMQL 1447

  Fly   389 SSFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERC 453
            :..::..::.|.||.|...:|||.|.||.||.||:.:|:||||:||:.|:||:||:||||||:|.
  Rat  1448 AVVVSEVLENGSSVWVCLEEGWDITTQVTSLVQLLSDPFYRTIEGFRMLVEKEWLSFGHKFSQRS 1512

  Fly   454 G-HIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLD 517
            . .:.:.....:|||.|||||..|:.:|....||||..:|..|..|..|.:|.||:.:.:.:||:
  Rat  1513 SLALNSQGSGFAPIFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLE 1577

  Fly   518 L---------KLAERTFSLW---GYMANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSR- 569
            .         |.|::...:|   ..|......:.|.||.|...||:|.|:....:|.| ..|:.
  Rat  1578 HGTLFDDKGDKHAKKGVCIWECIDKMHKRSPVFFNYLYSPVEIEALKPNVNVSSLKKW-DYYTEE 1641

  Fly   570 -FESGIHPREPLGDVLLDSKEHCNSLEDHVQ----HLTKRIASFKNYISKSAKKLQDAT-SAPGK 628
             ..:|     |..|.::.:.:|....|..|.    ..::|...:..|        .|.| |.|..
  Rat  1642 TLSAG-----PSYDWMMLTPKHFPYEESDVAGGAGPQSQRKTVWPCY--------DDVTCSQPDA 1693

  Fly   629 VNKELSSNEINDNKYN---------YDKKLSELSAAD-DDHPLKASNMS--FASLSLSAEQSSPP 681
            :.:..|..|..::|.|         ::|...:|.... .||.|:.|:.|  .||.::.:.|..|.
  Rat  1694 LTRLFSEIEKLEHKLNQTPEKWHQLWEKITMDLKEEPRTDHSLRHSSRSPGIASTNVPSYQKRPA 1758

  Fly   682 -QAL---PEEINSVAVDWKPMRNVTTCSCSTPFDQFSKK 716
             .||   |.|..|...  .|...|.. ..:|.:.|::.|
  Rat  1759 LHALHRSPTEDQSTTT--APSNGVEH-RAATLYSQYTSK 1794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	18/82 (22%)
		Myotub-related	179..514	CDD:284109	117/491 (24%)
		FYVE_MTMR_unchar	693..753	CDD:277277	5/24 (21%)
Sbf2	XP_008758019.1	uDENN	1..86	CDD:214824
		DENN	115..297	CDD:280329
		dDENN	351..419	CDD:129037
		SBF2	530..752	CDD:289132
		PH-GRAM_MTMR13	880..998	CDD:275416
		Myotub-related	1114..1574	CDD:284109	114/484 (24%)
		PH_Sbf1_hMTMR5	1797..1902	CDD:269941
		PH	1802..1902	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349477
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840