DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and mtmr7a

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001035406.1	Gene:	mtmr7a / 678558	ZFINID:	ZDB-GENE-060421-7754	Length:	655	Species:	Danio rerio

Alignment Length:	641	Identity:	293/641 - (45%)
Similarity:	411/641 - (64%)	Gaps:	41/641 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LKKVENVRMIDRYNTKNPTVGTLYLTATHLIFVEPDS--NKETWILHMHVASIEKLPLSTTGSPL 140
            :.||||||::||.:::...||||||||||.|||...|  ..|.|:||..|.:|.|...|.:|.||
Zfish     6 MPKVENVRLVDRSSSRKSQVGTLYLTATHTIFVGKGSEDRNELWVLHSLVCNIVKHKASQSGYPL 70

  Fly   141 LIRCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAGWDYFKLEAE 205
            ||.||.|..:.|:|.::|:.|:||.||.:|.:|....:||||::.|..|...:...||:..|:||
Zfish    71 LIHCKNFQVIQFIILQESDLHNVYISLTRLSRPEKYEELYCFSFNPAVDKAERQHSWDFIDLKAE 135

  Fly   206 FKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLT-YLHNNKA 269
            :..|.:||:.|.:..:|..|.:|||||..::|||..|..:::.||:|||:||.|.|: |...|.|
Zfish   136 YSRMGLPNKLWHVTPINRDYRVCDTYPADLFVPKSVTLPVIVGSSKFRSRGRFPTLSYYCKENHA 200

  Fly   270 SICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYEN 334
            :|||.||||||||||||||||||:||.|:|..:.:||||||||::|||||||||||||||..|.|
Zfish   201 TICRSSQPLSGFSARCLEDEQMLQAIMKSNPGSRFMYVVDTRPKLNAMANRAAGKGYENEDNYCN 265

  Fly   335 IKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAV-DK 398
            |||.|:|||||||.|.|.||::|....:||:|..|:..||:|.||||||||::...||:.|| |:
Zfish   266 IKFQFIGIENIHVMRNSQQKLIEVSALRSPSMGEFLLGLENSDWLKHIRSIMEAGIFISKAVADE 330

  Fly   399 GVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREV 463
            ||||:||||||||||:||||:|.::|:||||||||...||||||::||||||.||||:..:|:||
Zfish   331 GVSVLVHCSDGWDRTSQVCSVASVLLDPYYRTIKGMMVLIEKDWVSFGHKFSHRCGHLDGEAKEV 395

  Fly   464 SPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLW 528
            ||:..|||:|.||||.|...|||:||:||:.:|:||:|..:|.|:.|.:|:|.||::.|:|.|:|
Zfish   396 SPVLDQFLECVWQLMDQFPCAFEYNEKFLISIHNHVYSSHYGNFICNSQKERKDLRIREKTHSIW 460

  Fly   529 GYMANHLNEYINPLYKPNVDE---AIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEH 590
            .|:..:..:::|||:||:..:   .::.:.||.|.|:||.:|:||:..:|||:...|.|:..|:.
Zfish   461 PYLMENKLDFMNPLFKPDQIQNQGLLRPSTAPYCFKYWRRLYNRFDRELHPRQSELDCLMAVKDE 525

  Fly   591 CNSLEDHVQHLTKRIASFKN------YISKSAKKLQDAT----------------------SAPG 627
            ...||:.:....:::|....      |:.|...:.:.|.                      .||.
Zfish   526 TQQLEEEMALYEQKLAVLDKERAKILYMQKGVLESRQALWSVPLDVSLANTPQDYLGGFIGGAPN 590

  Fly   628 KVNKELSSNEINDNKYNYDK-KLSELSAADDDHPLKASNMSFASLSLSAEQSSPPQ 682
            ....:....|..:.....|| |.|:...:|.:     |.::..|...|.|:|.|.:
Zfish   591 VFTSQQGEKESTEFSLFGDKPKSSDAENSDQE-----SGVADFSCHSSGEESLPSE 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	47/96 (49%)
		Myotub-related	179..514	CDD:284109	196/336 (58%)
		FYVE_MTMR_unchar	693..753	CDD:277277
mtmr7a	NP_001035406.1	PH-GRAM_MTMR7	1..103	CDD:270152	47/96 (49%)
mtmr7a	NP_001035406.1	Myotub-related	109..446	CDD:284109	196/336 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590743
Domainoid	1	1.000	438	1.000	Domainoid score	I539
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I859
OMA	1	1.010	-	-		QHG49274
OrthoDB	1	1.010	-	-		D192248at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		otm24934
orthoMCL	1	0.900	-	-		OOG6_101828
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770