DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and MTMR9

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_056273.2	Gene:	MTMR9 / 66036	HGNCID:	14596	Length:	549	Species:	Homo sapiens

Alignment Length:	540	Identity:	192/540 - (35%)
Similarity:	305/540 - (56%)	Gaps:	20/540 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KVENVRMIDRYNTKNPTV-GTLYLTATHLIF-VEPDSNKETWILHMHVASIEKLPLSTTGSPLLI 142
            :|:||.:   :....|.| |||.||..|||. ...|:.:|.|:||.::.:|:|..:.:.|: ::|
Human    11 RVDNVVL---HRPFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDKRFVGSLGT-III 71

  Fly   143 RCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAGWDYFKLEAEFK 207
            :||.|..:...||...||.::.:|:..|....||..:|.|.|:|..:..  ..||..|..|.||:
Human    72 KCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMFEVI--EDGWHSFLPEQEFE 134

  Fly   208 HMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASI 271
            ........|.|..:|:::.:|.:||..:.|||......|...:.||..||.|||:|.| .|...|
Human   135 LYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVI 199

  Fly   272 CRCSQPLSGFSA-RCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENI 335
            .|..|||:|.:. ||.|||:::.|..:.....   |::|||....|...||.|.|:|.||.|...
Human   200 MRSGQPLTGTNGRRCKEDEKLINATLRAGKRG---YIIDTRSLNVAQQTRAKGGGFEQEAHYPQW 261

  Fly   336 KFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDK-G 399
            :.....||..|:.:.||.|::|||..::..|..:::.||:|.||.||:.||.|:...|..:|: |
Human   262 RRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWLTHIKEILTTACLAAQCIDREG 326

  Fly   400 VSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERC---GHIQTDAR 461
            .|:::|.::|.|.|.||.||||::|.|..|||:||:||||::||..||.|.:||   .:..|..:
Human   327 ASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQK 391

  Fly   462 EVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFS 526
            ..:|:|..||||.||::.|...:|||||.||::|.:|.::.|||||:||.|.:|..|||.::|.|
Human   392 WEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMS 456

  Fly   527 LWGYM--ANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKE 589
            ||.::  .:.|:::.|||::.| :..|..::|||.:..|.|::.|:.......:...:.:::..|
Human   457 LWSWVNQPSELSKFTNPLFEAN-NLVIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIE 520

  Fly   590 HCNSLEDHVQHLTKRIASFK 609
            :...|:..|..|.:::|..:
Human   521 YNKELQAKVNILRRQLAELE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	31/94 (33%)
		Myotub-related	179..514	CDD:284109	134/340 (39%)
		FYVE_MTMR_unchar	693..753	CDD:277277
MTMR9	NP_056273.2	PH-GRAM_MTMR9	1..97	CDD:275398	30/89 (34%)
MTMR9	NP_056273.2	Myotub-related	127..446	CDD:310891	128/321 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192248at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750