DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and mtmr12

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_009299937.1	Gene:	mtmr12 / 569130	ZFINID:	ZDB-GENE-050401-1	Length:	753	Species:	Danio rerio

Alignment Length:	557	Identity:	143/557 - (25%)
Similarity:	238/557 - (42%)	Gaps:	131/557 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VFYNGNSVLKKVENVRMIDRYNTKNPTVGTLYLTATHLIFVEPDSNKETW--------------- 119
            ||.:.|.:||..::..      ::....|||..|...:.|:..|:.:|..
Zfish    46 VFCSANPILKYTQDDL------SQRGVFGTLLCTNFRVAFISDDAPQEEMSKTFKNKLYGENDIP 104

  Fly   120 ---ILHMHVASIEKLPLSTTG-------SPLLIRCKTF----LSVTFVIPKDSECHDVYTSLLKL 170
               :.|::....||..|.|.|       |.::|.||..    ..:||...:|::         ::
Zfish   105 LMCVDHIYGVYDEKRKLITGGLVKNKCPSKMIIHCKDLRVFQFCLTFSKEEDAK---------RI 160

  Fly   171 FQPV--------SINKLYCFNY-QPNKDDFPKNAGWDYFKLEAEFKHMLVPNEA--------WT- 217
            ||.:        |:..::.|:| :....|..|::.....:|::: ..||...||        ||
Zfish   161 FQGIAHHCLEEKSLKCVFAFSYLRSTNPDHGKSSRKCITRLDSK-SEMLRKREAIMFDSPEDWTQ 224

  Fly   218 ----------LCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHNNKASIC 272
                      |.:.||.:||....|:...:|.....|.     .::.|| ||:..:.|::..::.
Zfish   225 EMKRTKAQCRLVTENENFELSQRLPQYFVIPSALGDLF-----NYQGKG-LPIWCWSHHSGCALF 283

  Fly   273 RCSQPLSGFSARCLED-------EQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEA 330
            :.|     |.:...||       :.|:.|:.:     :|:|.|.|.....::...     .:.:.
Zfish   284 KAS-----FPSMTQEDGDFQSHLDTMITAVAR-----NYLYSVKTEDLSESLPTL-----QDIQQ 333

  Fly   331 FYENIKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANA 395
            .|...|.:|| |:|......|..|              :.::|||||||..||..|..:..:...
Zfish   334 SYNKFKQYFL-IDNTTDFWLSDVK--------------WFSSLESSGWLDIIRQCLQKAVEVVEC 383

  Fly   396 VDK-GVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHI-QT 458
            ::| ..:|::...:|.|....:.||||:||:|||||:.|||:|::|:|:|..|.|.:||.|: |.
Zfish   384 LEKDNTNVLITEEEGTDLCCVISSLAQIMLDPYYRTLMGFQSLVQKEWVAGCHAFLDRCNHLHQK 448

  Fly   459 DAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAER 523
            |....||:|..||:|.|||:.|.|.||:|:|.:|.:|.|.||...|.||:.|....|..:..||.
Zfish   449 DKECHSPVFLLFLECVWQLVQQHSPAFQFSETYLTVLSDSVHVPIFSTFLFNSAHHRESVMKAES 513

  Fly   524 TF---------SLWGYM----ANHLNEYINPLYKPNV 547
            ..         ::|.:.    :...|.:.||||...|
Zfish   514 PIAQSRPLSCPTVWDWSVQFDSKAQNFFFNPLYSEKV 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	23/123 (19%)
		Myotub-related	179..514	CDD:284109	105/363 (29%)
		FYVE_MTMR_unchar	693..753	CDD:277277
mtmr12	XP_009299937.1	PH-like	21..215	CDD:302622	37/184 (20%)
		PTPc	221..501	CDD:304379	95/315 (30%)
		3-PAP	566..692	CDD:289355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590745
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740