DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and sbf1

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_009298445.1	Gene:	sbf1 / 568277	ZFINID:	ZDB-GENE-040718-139	Length:	1936	Species:	Danio rerio

Alignment Length:	1033	Identity:	212/1033 - (20%)
Similarity:	344/1033 - (33%)	Gaps:	374/1033 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ITRFMNKF-----NEIERQLSPTSALRLSFDNISPETEEPPDG----NKRLWGVPVPPFVSEKVV 58
            :.||:|:|     ||.........||.....:|.....|..|.    :|||     ||....|::
Zfish   843 VVRFINRFVDKVCNESGVTNEHLKALHTMIPDIVQMHIETLDAVHRESKRL-----PPIQKPKLL 902

  Fly    59 SWIEEEFNEAPVFYNGNSVLKKVENVRMIDRYNTKN----------PTVGTLYLTATHLIF---- 109
                     .|....|...:.....|.:|.....:.          |..|.::||:..|||
Zfish   903 ---------RPTLLPGEEFVMDGMRVHLITDGREEATGSMGGPPLLPAEGAIFLTSYRLIFKGTP 958

  Fly   110 VEPDSNKETWILHMHVASIEKLPLSTTGSP--------LLIRCKTF--LSVTFVIPKDSECHDVY 164
            .:|...::.......|||:.|....:...|        |.:|..||  :.:.|.....|:..:|:
Zfish   959 TDPLVGEQVVTRSFPVASLTKEKRISVSLPMDQFIQEGLQLRSCTFQLMKIAFDEEVASDLAEVF 1023

  Fly   165 TS-LLKLFQPVSINKLYCF--------------------------------------------NY 184
            .. :.||..|..:...:.|                                            .|
Zfish  1024 RKHMHKLRYPQHVQGTFAFTVGQSAKLVVEHKTKDKNQSLKTLSRNLVKTAKRTIGRQYVTRKKY 1088

  Fly   185 QP----NKDDFPKNAGWDYFKLEAE---------------------------------------F 206
            .|    |:.........|...:..|                                       .
Zfish  1089 SPPTWENRSSMQSEMDEDEISVSEEPEPSSLTLSSTIRSSDRQTMSNVVERACCRDYQRLGLGTL 1153

  Fly   207 KHMLV--PNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHN-NK 268
            .:.|.  .||.:.:.::|..|.:|.:||..:.||:......:....|...:.|.||:.:.:: .|
Zfish  1154 SNSLTRSKNEPFRISTVNRMYTVCRSYPGLLIVPQSIPDSTIQRICRCYRQNRFPVVCWRNSRTK 1218

  Fly   269 ASICRC---------------SQPLSGFS---ARCLEDEQMLEAI------------RKTNS--N 301
            |.:.|.               :.|.:|.|   :..||.|:.|:||            |.|.|  .
Zfish  1219 AVLLRSAGLHAKGVVGFFKSPNAPTAGPSQADSTSLEQEKYLQAIISSMPSYSETSGRNTLSGFT 1283

  Fly   302 TDYMYVVDT-----RPRINAM-------------------------------------------- 317
            :.:|...|:     :|:|.|:
Zfish  1284 SSHMSTSDSSDKLRQPKIGALMKQVMGAKEDVPGTFSRGALGQRARVVSLSQPRVSVKARNSPRG 1348

  Fly   318 ------------------ANRAAGK------GYENEAFY--------------ENIK-------- 336
                              .||.|||      |..:|.::              ..:|
Zfish  1349 KWGSIRGSGRLSTYNPDVGNRLAGKESPQANGGPSETYFLRQQRAYLFIIGDKSQLKGGKQDSFQ 1413

  Fly   337 -FHFLGIENIHVQRA--SLQKVLEACEQKSPTMSA---FINALESSGWLKHIRSILDTSSFIANA 395
             :..:.||...|::.  |.:|:::||...|.:..|   |...||.|.|:..:..:|..|..:...
Zfish  1414 QWEVVPIEVFDVRQVKNSFKKLMKACVPSSLSFDANMTFHRCLEESEWMNLLHRVLQVSVLVVEL 1478

  Fly   396 VDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDA 460
            :|.|.||:|...||||.|.||.||.||:.:||||||.||:.|:||:||:|||:||.|  ..||.|
Zfish  1479 LDNGSSVMVSLEDGWDVTTQVVSLVQLLSDPYYRTIDGFRLLVEKEWLSFGHRFSHR--GAQTLA 1541

  Fly   461 REVS---PIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDL---- 518
            .:.|   |:|.|||||..|:..|....|||::.:|..|..|..|.:|.||:.:.:.:|::|
Zfish  1542 SQSSGFTPVFLQFLDCVHQIHLQFPMEFEFSQYYLKFLAYHYVSNRFRTFLLDSDYERIELGVLY 1606

  Fly   519 ------KLAERTFSLWGYMANHLNE----YINPLYKPNVDEAIKANLAPQCIKFW---------- 563
                  |..:...|:|.|: :.||:    :.|.::.|..:|.:|.......:|.|
Zfish  1607 EEKGERKSTQVCKSVWDYI-DRLNKKTPIFYNYMFSPEEEEVLKPYSFVSNLKVWDFYTEETLSE 1670

  Fly   564 ---------RGMYSRFESGIHPREPLGDVLLDSKEHCNS------------------LEDHVQHL 601
                     :|...:      |:|..||     |:...:                  :.|.:..|
Zfish  1671 GPSFDWELVQGRQEK------PQEEAGD-----KQETTAPKSKRRIVWPCYDNLSKVVPDAITKL 1724

  Fly   602 TKRIASFKNYISKSAKKLQDA---TSAPGKVNKELSSNEINDNKYNYDKKLSELSAADDDHPLKA 663
            .:.:.:.:..:.:..:|.:|.   .....:|...|.|      ::::...|           |.:
Zfish  1725 LQDVQNLETELGQPTEKWKDTWDKIKTTQRVESRLES------RHSFSSSL-----------LMS 1772

  Fly   664 SNMSF------ASLSLSAEQSSPPQALPEEIN--SVAVDWKPMRNVTTCSCSTPFDQF 713
            ||:|.      ..|..|...||...||..|::  |.....:|       |.||.:.||
Zfish  1773 SNLSHQRRSQGVYLQESGVGSSINLALDCEVSATSTPAAGRP-------STSTLYSQF 1823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	24/119 (20%)
		Myotub-related	179..514	CDD:284109	122/560 (22%)
		FYVE_MTMR_unchar	693..753	CDD:277277	6/21 (29%)
sbf1	XP_009298445.1	uDENN	1..86	CDD:214824
		DENN	117..327	CDD:280329
		dDENN	381..449	CDD:129037
		SBF2	560..782	CDD:289132
		PH-GRAM_MTMR5	910..1027	CDD:275417	22/116 (19%)
		Myotub-related	1143..1598	CDD:284109	116/456 (25%)
		PH_Sbf1_hMTMR5	1829..1934	CDD:269941
		PH	1834..1934	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840