DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and mtm1

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001032773.2	Gene:	mtm1 / 560881	ZFINID:	ZDB-GENE-051113-128	Length:	639	Species:	Danio rerio

Alignment Length:	661	Identity:	226/661 - (34%)
Similarity:	352/661 - (53%)	Gaps:	80/661 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LRLSFDN--ISPETEEPPDGNKRLWGVPVPPFVSEKVVSWIEEEFNEAPVFYNGNSVLK------ 79
            |||..:|  ::...|.....|..:...|:.|             :|.:|:   |||..:
Zfish    11 LRLLRENSRLNAALESCRKVNAVMASAPIAP-------------YNSSPL---GNSSSQNASRES 59

  Fly    80 -KVENV----------RMIDR-------YNTKNPTVGTLYLTATHLIFVEPDSNKE-TWILHMHV 125
             |:|.:          |:||:       ||.  ...|.:::|...|.|...||... |..:.:.|
Zfish    60 LKMEPLADVTLLPGEERVIDKDIIYICPYNA--AVKGKVFITNYRLYFKNTDSETPVTLNIPLGV 122

  Fly   126 AS-IEKL-PLSTTGS---PLLIRCKTFLSVTFVIPKDSEC-HDVYTSLLKLFQPVSIN-KLYCFN 183
            .| :||: ..|:.|.   .|.|.||...::.|.:.::... .|::..:.|...|:|.. :|:.|.
Zfish   123 ISRVEKMGGASSRGENSYGLEITCKDMRNLRFALKQEGHSRRDIFEIIFKYAFPLSHGMQLFAFL 187

  Fly   184 YQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLIS 248
            .|   :.:.:| ||:.::...|::...:||..|.:..:|:.||||||||..:.||.:||...|..
Zfish   188 SQ---EKYEEN-GWNVYEALEEYRRQGLPNNEWRVTFINKNYELCDTYPTILVVPYKATEDDLRK 248

  Fly   249 SSRFRSKGRLPVLTYLH-NNKASICRCSQPLSGFSA-RCLEDEQMLEAIRKTNSNTDYMYVVDTR 311
            .:.|||:.|:||:::.| .|.|.|.||||||.|.|. |..:||:.|:.||:.|..|. :.:.|.|
Zfish   249 VATFRSRCRIPVMSWFHKENHAVITRCSQPLVGMSGKRNKDDERYLDLIREANGTTK-LTIYDAR 312

  Fly   312 PRINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESS 376
            |.:||:||:|.|.|||.:..|:|.:..||.|.||||.|.||:| |:.....:...|.::::|||:
Zfish   313 PNVNAVANKATGGGYEGDDAYQNAELVFLDIHNIHVMRESLKK-LKDIVYPNVEESHWLSSLEST 376

  Fly   377 GWLKHIRSILDTSSFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKD 441
            .||:||:.:|..:..:|:.|..|.||:||||||||||||:.||:.|||:.||||::|||.|:||:
Zfish   377 HWLEHIKLVLSGAIQVADKVSSGSSVMVHCSDGWDRTAQLTSLSMLMLDSYYRTLRGFQVLMEKE 441

  Fly   442 WLAFGHKFSERCGHIQTD--AREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQF 504
            |::|||||:.|.||...:  .::.||||.||:||.||:..|...|||||||.|:::.||::||:|
Zfish   442 WISFGHKFASRIGHGDKNHADQDRSPIFLQFIDCVWQMTKQFPTAFEFNERLLVVILDHLYSCRF 506

  Fly   505 GTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSR 569
            |||:.|||..|....:..:|.|||.|:.:..:.||||.|.|.....:....:.:.::.|...|.|
Zfish   507 GTFLYNCESVRDSNNVRTKTVSLWSYINSDTSLYINPFYTPESSRVLYPVASMRHLELWVTYYIR 571

  Fly   570 FESGIHPREPLGDVLLDSKEHCNSLEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGKVNKELS 634
            :...|..::                :..|:...|.:.:.::...|..::||.:.|||...:...|
Zfish   572 WNPRIQHQQ----------------QSPVEQRYKELLALRDQYLKKLEELQLSDSAPSSTHLTNS 620

  Fly   635 S--NEINDNKY 643
            |  |....|::
Zfish   621 STPNAATPNQH 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	27/125 (22%)
		Myotub-related	179..514	CDD:284109	156/338 (46%)
		FYVE_MTMR_unchar	693..753	CDD:277277
mtm1	NP_001032773.2	PH-like	77..176	CDD:327399	24/100 (24%)
mtm1	NP_001032773.2	Myotub-related	199..517	CDD:310891	150/319 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850