DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3530 and zgc:154055

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001070610.1	Gene:	zgc:154055 / 556036	ZFINID:	ZDB-GENE-060929-612	Length:	567	Species:	Danio rerio

Alignment Length:	564	Identity:	184/564 - (32%)
Similarity:	297/564 - (52%)	Gaps:	48/564 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KVENVRMIDRYNTKNPTV-GTLYLTATHLIFVEPDSNKETW---ILHMHVASIEKLPLSTTGSP- 139
            |..||..:......:|.: |||.:|:.||:|.: ..::.:|   ||..::.:|||...:..|.|
Zfish     9 KTANVEDVTLRRPFHPALRGTLCVTSHHLLFSD-RKDEASWQLLILLKNIDAIEKSVENLFGYPR 72

  Fly   140 --------LLIRCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAG 196
                    :.|:||..|.:...||...||.::.:|:..|....|:.::|.|.|:|:  ....:..
Zfish    73 AVGQSSGTITIKCKDLLVLQLEIPGMEECLNIASSIEALSSLESVTEMYPFFYRPS--HLALHGP 135

  Fly   197 WDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVL 261
            |.....|..:|......:.|.:.::|..|.:|.:||..:.||:|.....|:.|:|||...|.|||
Zfish   136 WGLSSTEQYYKQTERLWDKWRVSTVNSDYSVCPSYPSAVIVPREVDDDKLVRSARFRQGSRFPVL 200

  Fly   262 TYLHN-NKASICRCSQPLSGFS-ARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGK 324
            :|.|: |:..|.|.||||:|.: .||.|||.:|:|:   ...::..|::|.|....|...|..|.
Zfish   201 SYCHHRNRMVIMRSSQPLTGANRKRCREDELVLQAV---IDGSEMGYIIDLRSAQQAQQARMTGG 262

  Fly   325 GYENEAFYENIKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTS 389
            |:|:::.|.|.|......|...|.:.||.|::|||..:|.::..:::.||:|.||.|:.|.|.|:
Zfish   263 GFESKSSYNNWKRIHRHHERGKVLQESLIKLVEACGDQSHSVDRWLSKLENSKWLSHVHSALSTA 327

  Fly   390 SFIANAVDKGV-SVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERC 453
            ..:|..|::.. ||:||.|:|.|.|..|.|||||:|:|..|::.||..|:|:||:..||.|..||
Zfish   328 GLVAECVERDAHSVLVHGSEGTDNTLLVSSLAQLILDPASRSLSGFLCLLERDWIQAGHPFQLRC 392

  Fly   454 GH-IQTDAR--EVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDR 515
            .| ..:.||  :..|.|...|||.||:..|...|.||:|..||.|...|::..:|||:.|.|::|
Zfish   393 VHSAYSHARLKQECPTFLLLLDCVWQVWRQFPLAMEFSEALLLRLAQDVYASDYGTFLCNSEQER 457

  Fly   516 LDLKLAERTFSLW-GYMANHLNE-YINPLYKPNVDEAIKANLAPQCIKFWRGMYSRF----ESGI 574
            ....:.|:|..|: ..:...::| |:||||:| .|.||..::.||.::.|.|::.|:    ::..
Zfish   458 YAAGVKEKTHCLFQALLKPDIDEQYLNPLYEP-TDLAIWPSVHPQSLQLWTGLFLRWTEYAQNME 521

  Fly   575 HPREPLGDVLLDSKE-------------HCNSL---EDHVQHLT 602
            ..||.:..::.:.||             ||::|   |:.:..||
Zfish   522 EAREEVWSIVKEHKERAGSDRTNNNTSTHCDTLTPFENLMDELT 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	29/105 (28%)
		Myotub-related	179..514	CDD:284109	125/340 (37%)
		FYVE_MTMR_unchar	693..753	CDD:277277
zgc:154055	NP_001070610.1	PH-GRAM_MTMR9	1..109	CDD:275398	28/100 (28%)
zgc:154055	NP_001070610.1	Myotub-related	120..456	CDD:284109	125/340 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590750
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192248at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850