DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3530 and mtmr10

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_005168938.1	Gene:	mtmr10 / 555239	ZFINID:	ZDB-GENE-061103-52	Length:	765	Species:	Danio rerio

Alignment Length:	698	Identity:	151/698 - (21%)
Similarity:	272/698 - (38%)	Gaps:	165/698 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 VASIEKLPLSTTGSPLLIRCKTFLSVTFVI----PKDSECHDVYTSLLKLFQPVSINKLYCFNY- 184
            :.|.:||..:.|  .|::.||.|..:.|..    |:.::  .|..::.....|.....|:.|.|
Zfish   120 LGSNQKLKFNPT--ELILYCKDFRIIRFRFDEAGPESAK--KVCLAIAHYSHPADPQLLFGFEYV 180

  Fly   185 ----------QPNKDD---------FPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDT 230
                      :.|..|         |..::.||     .|.|.  .....|.:|::|:.|.:..:
Zfish   181 GKRYHGSAGERVNGVDPGGGLQTPLFDCSSDWD-----REIKR--TGASEWRVCTINQGYFISPS 238

  Fly   231 YPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHNNKASICRCSQPLSGFSARCLEDEQMLEAI 295
            .|....||.......|...:......|:|:..:.|...:::.|.|.         :.|.|....:
Zfish   239 LPEFFVVPVSLADQDLKQYACCFYSQRIPLWCWNHPCGSALVRMSN---------ISDPQQQRKV 294

  Fly   296 RKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEAC- 359
            .:..|:.    :..:.|             ..::.|..::..:...|::|   :|:|.|:.:.|
Zfish   295 EQRISSA----ITKSHP-------------LRSDVFKSDLDKNLPNIQDI---QAALLKLRQICV 339

  Fly   360 -EQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVD-------KGVSVVVHCSDGWDRTAQV 416
             |....:...::::||||.|::::|      :|:.:||:       :.|||::...:..|.:..:
Zfish   340 IESFEESEEKWLSSLESSRWMEYVR------TFLRHAVEVVYMLESRHVSVILLEKEDRDLSCVI 398

  Fly   417 CSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREVSPIFTQFLDCTWQLMSQR 481
            .||.|||.:|:.|::.||||||:|:|:..||:|.:||.|::...:|.||:|..||||.|||.:|.
Zfish   399 SSLVQLMCDPHCRSLHGFQALIQKEWVMAGHRFLDRCNHLKKSDKEESPLFLLFLDCVWQLWNQY 463

  Fly   482 SEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNE--------- 537
            ..||||.|.:|.:|.|.:....|.||:.||.:.|     ||.:.......:.||.:
Zfish   464 PAAFEFTEVYLTVLGDSMWVPVFSTFLFNCPRQR-----AEHSRDFASSKSIHLGQDQALRFPPV 523

  Fly   538 --------------YINPLYKPNVDEAI-------------KANLAPQCIKFWRGMYSRFESG-I 574
                          :.||||...:...:             |.|.:...    ||:.|...:| :
Zfish   524 WDWSQQFSLKDQTLFNNPLYVGKIATCLQNGTVKTFTHRRSKKNYSSTV----RGLPSLMRNGSL 584

  Fly   575 HPREPL---GDVLLDSKEHCNSLEDH------------------------VQHLTKRIASFKNYI 612
            .|.:.|   ..::|..:...:.:.:.                        .|.|...::.:|.|.
Zfish   585 GPNDTLTRRNSLVLRLRSDLSQVREQPETPSERFVRDFFSRAVDLQGLLLPQLLPSHLSVWKLYF 649

  Fly   613 SKSAKKLQDATSAPGKVNKELS--SNEINDNKYNYDKKLSELSAADDDHPLKASNMSFASLSLSA 675
            .:...:.|.....|.....:||  ::||...:....:.......|:..| .:.|.|.|.:.|...
Zfish   650 LRWVPEAQIPHGGPVTAFHKLSVLTDEIEMLQNQLRQYKGAAGTANTSH-AEHSKMYFKATSTPQ 713

  Fly   676 EQSSPPQALPEEINSVAVDWKPMRNVTTCS---CSTPFDQFSKKTHCW 720
            :..:||:.|     |.:..:.|:.|:  |.   ..||..:|......|
Zfish   714 QCPAPPEYL-----SSSFPFSPVGNL--CRPGILGTPLSKFLNGAKIW 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	11/51 (22%)
		Myotub-related	179..514	CDD:284109	94/363 (26%)
		FYVE_MTMR_unchar	693..753	CDD:277277	7/31 (23%)
mtmr10	XP_005168938.1	PH-GRAM_MTMR10	20..196	CDD:270154	16/79 (20%)
		PTPc	208..496	CDD:304379	88/329 (27%)
		3-PAP	566..689	CDD:289355	18/126 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740