DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3530 and MTMR12

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001035536.1	Gene:	MTMR12 / 54545	HGNCID:	18191	Length:	747	Species:	Homo sapiens

Alignment Length:	749	Identity:	185/749 - (24%)
Similarity:	300/749 - (40%)	Gaps:	192/749 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PVPPFVS----------EKVVSWIEEEFNEAP---VFYNGNSVLKKVEN--------VRMI---- 87
            |.|.|||          ||.|:..|...:..|   :....::|||.|:.        .|::
Human    16 PKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDF 80

  Fly    88 --------------DRYNTKNPTVG--TLYLTATHLIFVEPDSNKETWILHMHVASIEKLPLSTT 136
                          |....||..:|  .:.|.....|:...|..|:|..     ..::|.|
Human    81 KIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKTLF-----GQLKKYP---- 136

  Fly   137 GSPLLIRCKTFLSVTFVI--PKDSECHDVYTSLLKLFQ-PVSINKLYCFNY----QPNKDDFPKN 194
             ..|:|.||......|.:  .|:.|...:.:.::...| |..:.:|:.|:|    |.|....|||
Human   137 -EKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKN 200

  Fly   195 AG----------WDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISS 249
            ..          |:..:.:...|:..|        |:||.|::|:..|....||   |.|...:.
Human   201 HTVMFDTLKDWCWELERTKGNMKYKAV--------SVNEGYKVCERLPAYFVVP---TPLPEENV 254

  Fly   250 SRFRSKGRLPVLTY-LHNNKASICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPR 313
            .||:..| :|:..: .||..|.:...:.|..       :|:.:|: |:|  |..|.:|....||.
Human   255 QRFQGHG-IPIWCWSCHNGSALLKMSALPKE-------QDDGILQ-IQK--SFLDGIYKTIHRPP 308

  Fly   314 INAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQK--VLEACEQKSPTMSAFINALESS 376
            ...:..             |::..:||.::.|....:..::  :::...:...|...:.:.||||
Human   309 YEIVKT-------------EDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESS 360

  Fly   377 GWLKHIRSILDTSSFIANAVD-KGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEK 440
            .||..||..|..:..|...:: :.::|::...:..|....:.||.|||::|:.||..|||:||:|
Human   361 SWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQK 425

  Fly   441 DWLAFGHKFSERCGHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFG 505
            :|:..||.|.:||.|::.:.:|..|:|..||||.|||:.|...||||.|.:|.:|.|.::...|.
Human   426 EWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFS 490

  Fly   506 TFVGNC--EKDRLDLKLAERT-------FSLWGY------MANHLNEYINPLY--KPNVDEAIKA 553
            ||..|.  :||....:..:.|       .::|.:      .|..|.:  ||||  ||.:|:..:
Human   491 TFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLK--NPLYVEKPKLDKGQR- 552

  Fly   554 NLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNS--LEDHVQHLTKRIASFKNYISKSA 616
                      :||  ||:   |.|: |...|..||.....  ..:...||      .||.:.|..
Human   553 ----------KGM--RFK---HQRQ-LSLPLTQSKSSPKRGFFREETDHL------IKNLLGKRI 595

  Fly   617 KKLQDATSAPGKVNKELSSNEINDN-KYNYDKKLSELSAADDDHPLKASNM-------------- 666
            .||         :|   ||:|:.|| :..||   |..|.:.|.|.|...::
Human   596 SKL---------IN---SSDELQDNFREFYD---SWHSKSTDYHGLLLPHIEGPEIKVWAQRYLR 645

  Fly   667 -----------SFASLSLSAEQSSPPQALPEEIN 689
                       ..|:||...|.....|:|.|:|:
Human   646 WIPEAQILGGGQVATLSKLLEMMEEVQSLQEKID 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	23/125 (18%)
		Myotub-related	179..514	CDD:284109	99/354 (28%)
		FYVE_MTMR_unchar	693..753	CDD:277277
MTMR12	NP_001035536.1	PH-like	26..202	CDD:327399	38/185 (21%)
		PTPc	228..496	CDD:328744	87/294 (30%)
		Interaction with MTM1. /evidence=ECO:0000269\|PubMed:12847286	449..558		38/123 (31%)
		3-PAP	563..686	CDD:315286	32/138 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740