DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and mtmr1b

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001014352.1	Gene:	mtmr1b / 541517	ZFINID:	ZDB-GENE-050327-48	Length:	649	Species:	Danio rerio

Alignment Length:	656	Identity:	223/656 - (33%)
Similarity:	349/656 - (53%)	Gaps:	91/656 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDITRFMNKFNEIERQLSPTSALRLSFDNISPETEEPPDGNKRLWGVPVPPFVSEKVVSWIEEEF 65
            |::..|:  .:...:|.:|:||||              :|||                   :.:.
Zfish    56 MEVKGFL--LDSDPQQTAPSSALR--------------EGNK-------------------QAQM 85

  Fly    66 NEAPVFYNGNSVLKKVENVRMIDRYNTKNPTVGTLYLTATHLIF--VEPDSNKETWILHMH---V 125
            .|||.. .|.::...|::|..|..::  ....|||.:|...|.|  :..||   .::|.::   |
Zfish    86 EEAPRI-PGETIKAIVKDVMYICPFS--GVIRGTLTITDFKLYFKSLTRDS---PFVLDVNLGAV 144

  Fly   126 ASIEKLPLSTTGSP---LLIRCKTFLSVTFVIPKDSECH-DVYTSLLKLFQPVSIN-KLYCFNYQ 185
            :.:|.:.:.:.|..   |.|.||...:..|...|:.:.: :::..|.|...|:|.| .|:.|.|
Zfish   145 SRLESIAVQSHGDDTQGLEIVCKDLRTPRFAYKKEGQSNLEMFKILSKYAFPLSHNLPLFAFKY- 208

  Fly   186 PNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSS 250
              ::.||:: ||..:...||:|...:|||:|.:..:|..||:|:|||..:.:|...|...|...:
Zfish   209 --RETFPED-GWKIYDPVAEYKRQGLPNESWIISKVNSGYEVCETYPALLVLPSNVTEDELKRVA 270

  Fly   251 RFRSKGRLPVLTYLH-NNKASICRCSQPLSGFS-ARCLEDEQMLEAIRKTNSNTDYMYVVDTRPR 313
            .||:|.|.|||:::| .::|:|.||.||..|.| .||.|||:.|:.|...|:.:..:.:.|.|..
Zfish   271 AFRAKRRFPVLSWIHPESQAAIVRCGQPQVGPSDRRCREDERYLQTILDANAQSHKLCIFDARQS 335

  Fly   314 INAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGW 378
            ..|..|:|...|||||:||.|::.:||.|.||||.|.||:|:.|...........|.| ::::.|
Zfish   336 TVADTNKAKDGGYENESFYINVELNFLEIPNIHVMRESLRKLKEVVYPAIDQQHWFSN-VDATHW 399

  Fly   379 LKHIRSILDTSSFIANAVDKG-VSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDW 442
            |:::|.:|..:..||:.::.| .|||||||||||||||:.|||.|||:.:||::||||.|:||:|
Zfish   400 LEYVRLLLAGAVRIADRIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDAHYRSLKGFQVLLEKEW 464

  Fly   443 LAFGHKFSERCGHIQTDAR----EVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQ 503
            |:|||:|:.|.||  .|..    |.||:|.||:||.||:..|...||||||.||:.:.||:.||.
Zfish   465 LSFGHRFASRVGH--GDGNHANSERSPLFVQFIDCVWQMTRQFPSAFEFNELFLITVLDHLFSCL 527

  Fly   504 FGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYKPNVDEAIKANLAP-QCIKFWRGMY 567
            ||||:.|.|::|:..::..:|.|||.|:.:.:.|:.|||| .|.:..:...:|. :.::.|...|
Zfish   528 FGTFLYNSEQERVSKEVYNKTVSLWSYVNSQIEEFTNPLY-VNYEHHVLYPIASLRHLELWVSYY 591

  Fly   568 SRFESGIHPREPLGDVLLDSKEHCNSLEDHVQHLTKRIASFKNYISKSAKKL-QDATSAPGKVNK 631
            .|:...:.|:.|:...|                  |.:...|:.:.|..:.| |||.|     :.
Zfish   592 VRWNPRMRPQVPIHQSL------------------KELLVLKSELQKRVEDLKQDAAS-----SN 633

  Fly   632 ELSSNE 637
            .|||:|
Zfish   634 SLSSSE 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	23/103 (22%)
		Myotub-related	179..514	CDD:284109	151/341 (44%)
		FYVE_MTMR_unchar	693..753	CDD:277277
mtmr1b	NP_001014352.1	PH-like	97..196	CDD:302622	23/103 (22%)
		Myotub-related	203..538	CDD:284109	151/341 (44%)
		3-PAP	<572..628	CDD:289355	11/73 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850