DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and sbf2

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_009301876.1	Gene:	sbf2 / 378456	ZFINID:	ZDB-GENE-030911-10	Length:	1898	Species:	Danio rerio

Alignment Length:	897	Identity:	201/897 - (22%)
Similarity:	324/897 - (36%)	Gaps:	270/897 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GVPVPPFVSEKVVSWIEEEFNEAPVFYNGNSVLKKVENVRMIDRYNTKNPTVGTLYLTAT----H 106
            |.|..|.|.|:.|      ....||     |.|.|.:.: .|.....:|...|....:|:    .
Zfish   936 GTPHDPLVGEQAV------IRSFPV-----STLTKEKKI-TIQNQLQQNMQEGLQLRSASFQLIK 988

  Fly   107 LIFVEPDSNKETWILHMHVASIEKLPLSTTGSPLLIRCKTFLSVTFVIPKDSECHDVYTSLLKLF 171
            :.|.|..|::...|...||..| :.|.|...:......:|  :...::||..|.:..:.:|.|..
Zfish   989 VAFDEEVSSEMVEIFRKHVQRI-RYPSSIFSTFAFAAGQT--APQLILPKQKERNTGFRTLSKTI 1050

  Fly   172 -----------------------------------------QPVSINKLYCFNYQPNKDDFPKNA 195
                                                     :|.|.|.|........:....:..
Zfish  1051 VKGAIKAGKITMGRQSTLKKNEKGSRMTWHEDDDISISDDGEPPSSNTLKASEKSTMEQLVERAC 1115

  Fly   196 GWDYFKLE----AEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKG 256
            ..||.:|.    :.....|...|.:.:.::|..|.||.:||..:.:|.......|...||.....
Zfish  1116 FRDYQRLGLGTISANSTRLKSGEQFRVTAVNRLYSLCRSYPGLLVIPHTVQDSSLQKVSRCYRHN 1180

  Fly   257 RLPVLTYLH-NNKASICR-------------------CSQPLSGFSARCLEDEQMLEAI------ 295
            ||||:.:.| ..||.:.|                   .:.|.|..::..||.|:.|:||
Zfish  1181 RLPVVCWKHPRTKAVLLRSGGFHSKSVVGLFKSQNPSSAAPTSSDTSSSLEQEKYLQAILSSIPI 1245

  Fly   296 --RKTNSNT--------------------------------------------DYMYVVDTR--- 311
              :...|||                                            |.::....:
Zfish  1246 YFKPNGSNTLTNRSLIGLSPASERRASRIPKMAPVHLDISFTNSFTRGVLGYRDKLFTHSNQKAS 1310

  Fly   312 -----------------------PRINAMANRAAGKGYENEAFYENI----------------KF 337
                                   |.:..:..|.|||........||:                |.
Zfish  1311 AKGRIHNQGVWASLRSSSRFIQHPAVGDVGARLAGKDLAPPTGIENLQAQLLKHQAALYIFGEKS 1375

  Fly   338 HFLGI--------ENIHVQ-------RASLQKVLEAC---EQKSPTMSAFINALESSGWLKHIRS 384
            ||.|:        |.:.|:       :||.:|:|.||   ...|.|..:|:.|||.|.|:..|..
Zfish  1376 HFRGLKLDPALNCELVPVEFADTRQVKASFKKLLRACAPSAMSSDTEDSFLKALEESEWMLQIHK 1440

  Fly   385 ILDTSSFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKF 449
            :|..:......:|.|.||:|...:|||.|.||.||.|::.:|:|||::|||.|:||:||:|||||
Zfish  1441 LLQLAVVAVELLDSGSSVLVSLEEGWDITTQVVSLTQVLSDPFYRTLEGFQVLLEKEWLSFGHKF 1505

  Fly   450 SERCGHIQTDAR--EVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCE 512
            |:| |::..:::  ..:|||.|||||..|:.:|....||||:.:|..|..|..|.:|..|:.:.:
Zfish  1506 SQR-GNLNPNSQGSGFTPIFLQFLDCVHQVHNQYPLEFEFNQYYLKFLAYHYVSNRFKNFLLDSD 1569

  Fly   513 KDRLD---------LKLAERTFSLWGYMANHLNE----YINPLYKPNVDE-AIKANLAPQCIKFW 563
            .:||:         .|.::|...:|..: |.::.    :.|.||.|:..| .:|..::...:..|
Zfish  1570 YERLEHGTLFEDKGEKQSKRGICIWECI-NRMHRKGPLFFNYLYSPSETEPVLKPLISIPNLTTW 1633

  Fly   564 RGMYSRFESGIHPREPLG----------DVLLDSKEHCNSLEDHVQHLTKRIASFKNYISKSAKK 618
                 .|.:|    |.|.          .|...|.|..:::.     .|||...:..|.|.|
Zfish  1634 -----EFYTG----ETLSTGPSYDWCMLTVRSQSMEESDTIA-----TTKRRIVWPCYSSVS--- 1681

  Fly   619 LQDATSAPGKVNKELSSNEINDNKYNYDKK--LSELSAADD--------DHPLKASNMSFASL-- 671
                .:.|..::|.|:..|..:.:.....:  .:.|..|.|        :..|:..::|.:.|
Zfish  1682 ----RAQPDAISKLLADIEKLEGEQGQHSEPWHTTLEKAIDGIQEDLKQEGNLRKQSLSISGLVP 1742

  Fly   672 --SLSAEQSS-----PPQALPEEINSVAVDWKPMRNVTTCSCSTPFDQFSKK 716
              :|.|.|..     |...|.|:.:..||:....|      .:|.::||:.|
Zfish  1743 TSNLQAYQRRSMLHLPDGGLGEDNSPAAVNGVHRR------AATLYNQFTPK 1788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	21/139 (15%)
		Myotub-related	179..514	CDD:284109	119/472 (25%)
		FYVE_MTMR_unchar	693..753	CDD:277277	6/24 (25%)
sbf2	XP_009301876.1	uDENN	1..85	CDD:214824
		DENN	121..302	CDD:214823
		dDENN	356..424	CDD:129037
		SBF2	535..761	CDD:289132
		PH-GRAM_MTMR13	889..1007	CDD:275416	19/82 (23%)
		Myotub-related	1117..1571	CDD:284109	118/454 (26%)
		PH_Sbf1_hMTMR5	1792..1896	CDD:269941
		PH	1796..1896	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930