DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and mtm

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	211/560 - (37%)
Similarity:	323/560 - (57%)	Gaps:	57/560 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KNPTVGTLYLTATHLIFVE-PDSNKETWI-----LHMHVASIEKLPLSTTGSP----LLIRCKTF 147
            :.|..|.|.:|...|.|.. |..::|..:     |.: :|.:||:..:|:...    :.|.||..
  Fly    69 RGPVFGALTITNYRLYFRSLPLRDQEPPVVVDVPLGV-IARVEKIGGATSRGENSYGIEIFCKDM 132

  Fly   148 LSVTFVIPKDSEC-HDVYTSLLKLFQPVSIN-KLYCFNYQPNKDDFPKNAGWD---YFKLEAEFK 207
            .::.|...:.:.. ..|:..|.....|:|.: :|:.|.:.. .:....|.|||   .::..||.:
  Fly   133 RNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAA-ANSVNGNGGWDGWAVYEPLAELR 196

  Fly   208 HMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASI 271
            .:.|||:.|....:||.|.:||:||....|||.|:...|...::|||:.|||||:::: ..:|:|
  Fly   197 RLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATI 261

  Fly   272 CRCSQPLSGFSA-RCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENI 335
            .||||||.|.|. |..:||..|..|.:.|:.:|.:.::|.||..||:||:|.|.|||:|..|:|:
  Fly   262 TRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNV 326

  Fly   336 KFHFLGIENIHVQRASLQKVLEACEQKSPTM--SAFINALESSGWLKHIRSILDTSSFIANAVD- 397
            :.:||.|.||||.|.||:||.|||   .||.  |.:..|::::.||||||.||..:..|.:.|:
  Fly   327 EINFLDIHNIHVMRESLRKVKEAC---FPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVET 388

  Fly   398 KGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGH---IQTD 459
            ...|||||||||||||||:.:|:.|:|:|:|||::||:.||||:||:|||||.:|.||   ..:|
  Fly   389 MSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSD 453

  Fly   460 AREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERT 524
            | :.||:|.||:|..||:..|.:.||||||.||:.:.||::||:||||:.|.|.:|:...|..:|
  Fly   454 A-DRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKT 517

  Fly   525 FSLWGYMANHLNEYINPLYKPNVDEAIKANLAP----QCIKFWRGMYSRFESGI--------HPR 577
            .|||.::.:.|::|:|||: |:.....:..|.|    :.::.|:|:|.|:..|:        ..|
  Fly   518 TSLWTHINSSLDQYLNPLF-PSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGCQRTR 581

  Fly   578 EPL----------GDVLLDSKEHCNSLEDHVQHLTKRIAS 607
            |.|          .::.|.|....||::     .|.|:||
  Fly   582 ELLSKQDQLFKLVNELRLKSNNRSNSMQ-----TTTRLAS 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	19/90 (21%)
		Myotub-related	179..514	CDD:284109	160/345 (46%)
		FYVE_MTMR_unchar	693..753	CDD:277277
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	19/90 (21%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	155/328 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462314
Domainoid	1	1.000	268	1.000	Domainoid score	I445
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I854
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D18864at33392
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		mtm1152
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1956
SonicParanoid	1	1.000	-	-		X213
	10	10.030