DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3530 and Mtmr12

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_006232108.1	Gene:	Mtmr12 / 310155	RGDID:	1307902	Length:	748	Species:	Rattus norvegicus

Alignment Length:	672	Identity:	162/672 - (24%)
Similarity:	269/672 - (40%)	Gaps:	148/672 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PVPPFVS----------EKVVSWIEE-EFNEAPVFYNGNSVLKKVENV-RMIDRYNTKNPTVGTL 100
            |.|.|||          ||.|:..|| ..:..|    |..:|.:...| :.:...:.:....|.|
  Rat    16 PKPSFVSYVRPEEIHTNEKEVTEKEEVTLHLLP----GEQLLCEASTVLKYVQEDSCQLGICGRL 76

  Fly   101 YLTATHLIFV-----EPDSNKETWILHMHVASIEKLPLSTTG---------------------SP 139
            ..|...:.|:     ..|:..||...: .:..:..:||....                     ..
  Rat    77 VCTDFRISFLGDEGSAVDNGAETHFKN-KIIGVNDIPLHCVDQIYGVFDEKKKPLFGQLKKYPEK 140

  Fly   140 LLIRCKTFLSVTFVI--PKDSECHDVYTSLLKLFQ-PVSINKLYCFNY---------QPNK---- 188
            |:|.||....:.|.:  .|:.|...:.:.::...| |..:.:|:.|:|         .|..
  Rat   141 LVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTAADPRNCTVM 205

  Fly   189 DDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFR 253
            .|.||:..|:..:.:...|:..|        |:||.|.:||..|....||   |.|:.....||:
  Rat   206 FDTPKDWCWELERTKGSVKYKTV--------SVNEGYRVCDRLPAYFVVP---TPLLEDDVKRFQ 259

  Fly   254 SKGRLPVLTYLHNNKASICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMA 318
            .:| :|:..:..:|.:::.:.|         .|..||...|::...|..|.:|....||....:.
  Rat   260 GRG-IPIWCWSCHNGSALLKMS---------ALPKEQDDSALQIQKSFLDGIYKTIHRPPYEMVK 314

  Fly   319 NRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQK--VLEACEQKSPTMSAFINALESSGWLKH 381
            .             |::..:||.::.|.......::  ::::..:...|...:.:.|||||||..
  Rat   315 T-------------EDLSSNFLSLQEIQSSYCKFKQLFLIDSSSEFWDTDVKWFSLLESSGWLDI 366

  Fly   382 IRSILDTSSFIANAVD-KGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAF 445
            ||..|..:..|...:: :.::|::...:..|....:.||.|:|::.:.||..|||:||:|:|:..
  Rat   367 IRRCLKRAIEIIECLEAQNMNVLLLEENASDLCCLLSSLVQVMMDAHCRTWTGFQSLIQKEWVMG 431

  Fly   446 GHKFSERCGHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGN 510
            ||.|.:||.|:....:|..|:|..||||.|||:.|...||||.|.:|.:|.|.::...|.||..|
  Rat   432 GHSFLDRCNHLHQSDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFN 496

  Fly   511 C--EKD----RLDLKLAERTFSL-----WGYMANHLNEYI--NPLY--KPNVDEAIKANLAPQCI 560
            .  :||    |..|....:..:|     |........:.:  ||||  ||.:|:..:..
  Rat   497 SPHQKDTNMGRESLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDKGQRKG------ 555

  Fly   561 KFWRGMYSRFESGIHPREPLGDVLLDSKEHCNS--LEDHVQHLTKRIASFKNYISKSAKKLQDAT 623
                   |||:   |.|: |...|..||.....  ..:...||      .||.:.|...||
  Rat   556 -------SRFK---HQRQ-LSLPLTQSKSSPKRGFFREETDHL------IKNLLGKRISKL---- 599

  Fly   624 SAPGKVNKELSSNEINDNKYNY 645
                 :|   ||:::.||...:
  Rat   600 -----IN---SSDDLQDNSREF 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	19/124 (15%)
		Myotub-related	179..514	CDD:284109	96/352 (27%)
		FYVE_MTMR_unchar	693..753	CDD:277277
Mtmr12	XP_006232108.1	PH-like	26..192	CDD:302622	30/170 (18%)
		PTPc	211..497	CDD:304379	88/319 (28%)
		3-PAP	562..686	CDD:289355	17/71 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349479
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740