Protein Alignment Mtmr6 and Mtmr12

DIOPT Version :10

• Sequence 1: NP_726322.1
• Gene: Mtmr6 / 37707
• FlyBaseID: FBgn0028497
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001401964.1
• Gene: Mtmr12 / 310155
• RGDID: 1307902
• Length: 748
• Species: Rattus norvegicus
• Alignment Length: 672
• Identity: 162/672 - (24%)
• Similarity: 269/672 - (40%)
• Gaps: 148/672 - (22%)

  Fly    48 PVPPFVS----------EKVVSWIEE-EFNEAPVFYNGNSVLKKVENV-RMIDRYNTKNPTVGTL 100
            |.|.|||          ||.|:..|| ..:..|    |..:|.:...| :.:...:.:....|.|
  Rat    16 PKPSFVSYVRPEEIHTNEKEVTEKEEVTLHLLP----GEQLLCEASTVLKYVQEDSCQLGICGRL 76

  Fly   101 YLTATHLIFV-----EPDSNKETWILHMHVASIEKLPLSTTG---------------------SP 139
            ..|...:.|:     ..|:..||...: .:..:..:||....                     ..
  Rat    77 VCTDFRISFLGDEGSAVDNGAETHFKN-KIIGVNDIPLHCVDQIYGVFDEKKKPLFGQLKKYPEK 140

  Fly   140 LLIRCKTFLSVTFVI--PKDSECHDVYTSLLKLFQ-PVSINKLYCFNY---------QPNK---- 188
            |:|.||....:.|.:  .|:.|...:.:.::...| |..:.:|:.|:|         .|..
  Rat   141 LVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTAADPRNCTVM 205

  Fly   189 DDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFR 253
            .|.||:..|:..:.:...|:..|        |:||.|.:||..|....||   |.|:.....||:
  Rat   206 FDTPKDWCWELERTKGSVKYKTV--------SVNEGYRVCDRLPAYFVVP---TPLLEDDVKRFQ 259

  Fly   254 SKGRLPVLTYLHNNKASICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMA 318
            .:| :|:..:..:|.:::.:.|         .|..||...|::...|..|.:|....||....:.
  Rat   260 GRG-IPIWCWSCHNGSALLKMS---------ALPKEQDDSALQIQKSFLDGIYKTIHRPPYEMVK 314

  Fly   319 NRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQK--VLEACEQKSPTMSAFINALESSGWLKH 381
            .             |::..:||.::.|.......::  ::::..:...|...:.:.|||||||..
  Rat   315 T-------------EDLSSNFLSLQEIQSSYCKFKQLFLIDSSSEFWDTDVKWFSLLESSGWLDI 366

  Fly   382 IRSILDTSSFIANAVD-KGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAF 445
            ||..|..:..|...:: :.::|::...:..|....:.||.|:|::.:.||..|||:||:|:|:..
  Rat   367 IRRCLKRAIEIIECLEAQNMNVLLLEENASDLCCLLSSLVQVMMDAHCRTWTGFQSLIQKEWVMG 431

  Fly   446 GHKFSERCGHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGN 510
            ||.|.:||.|:....:|..|:|..||||.|||:.|...||||.|.:|.:|.|.::...|.||..|
  Rat   432 GHSFLDRCNHLHQSDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFN 496

  Fly   511 C--EKD----RLDLKLAERTFSL-----WGYMANHLNEYI--NPLY--KPNVDEAIKANLAPQCI 560
            .  :||    |..|....:..:|     |........:.:  ||||  ||.:|:..:..
  Rat   497 SPHQKDTNMGRESLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDKGQRKG------ 555

  Fly   561 KFWRGMYSRFESGIHPREPLGDVLLDSKEHCNS--LEDHVQHLTKRIASFKNYISKSAKKLQDAT 623
                   |||:   |.|: |...|..||.....  ..:...||      .||.:.|...||
  Rat   556 -------SRFK---HQRQ-LSLPLTQSKSSPKRGFFREETDHL------IKNLLGKRISKL---- 599

  Fly   624 SAPGKVNKELSSNEINDNKYNY 645
                 :|   ||:::.||...:
  Rat   600 -----IN---SSDDLQDNSREF 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtmr6	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	19/124 (15%)
		PTP-MTMR6-like	202..501	CDD:350380	84/301 (28%)
		FYVE_MTMR_unchar	693..753	CDD:277277
Mtmr12	NP_001401964.1	PH-like	26..192	CDD:473070	30/170 (18%)
		PTP-MTMR12	261..463	CDD:350442	58/224 (26%)
		Interaction with MTM1. /evidence=ECO:0000250	450..559		37/121 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..576		10/43 (23%)
		3-PAP	560..686	CDD:463634	18/73 (25%)