Protein Alignment Mtmr6 and Mtmr6

DIOPT Version :10

• Sequence 1: NP_726322.1
• Gene: Mtmr6 / 37707
• FlyBaseID: FBgn0028497
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001381640.1
• Gene: Mtmr6 / 305935
• RGDID: 1305378
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 636
• Identity: 303/636 - (47%)
• Similarity: 418/636 - (65%)
• Gaps: 61/636 - (9%)

  Fly    80 KVENVRMIDRYNTKNPTV-GTLYLTATHLIFVEPDSNKETWILHMHVASIEKLPLSTTGSPLLIR 143
            |||.|:::||::|.|.:: ||||||||||:|::. ..|||||||.|:||:|||.|:|:|.||:|:
  Rat     8 KVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDA-HQKETWILHHHIASVEKLALTTSGCPLVIQ 71

  Fly   144 CKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAGWDYFKLEAEFKH 208
            ||.|..|.|::|::.:|||:|.|||:|.:......||.|:|.|.::|..:..||....|.||::.
  Rat    72 CKNFRIVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDTERLNGWQLIDLAAEYER 136

  Fly   209 MLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYL-HNNKASIC 272
            |.|||..|.|...|.:|::|:||||::|||:.|:..:::.||.||||||||||:|. ...:|:||
  Rat   137 MGVPNANWQLSDANREYKVCETYPRELYVPRTASRPVIVGSSNFRSKGRLPVLSYCQQGTEAAIC 201

  Fly   273 RCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRP------------------------- 312
            |||||||||||||||||.:|:||.|.|....|||||||||
  Rat   202 RCSQPLSGFSARCLEDEHLLQAISKANPGNRYMYVVDTRPKLRMQSWWDTQKDIGRIIVRISSKI 266

  Fly   313 -------------RINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEACEQKSP 364
                         |:|||||||||||||||..|.||:|.|:|||||||.|:||||:||....|..
  Rat   267 WNDEKIRESDEKKRLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGSKGL 331

  Fly   365 TMSAFINALESSGWLKHIRSILDTSSFIANA-VDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYY 428
            :::.|.:.|||||||:||:::||.:.|:|.| |.:..||:||||||||||:|||||..|:|:.||
  Rat   332 SVNDFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCSLGSLLLDSYY 396

  Fly   429 RTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLL 493
            ||:|||..||||||::|||||||||||:..|.:||||:|||||:|.|.|..|..:||||||.|||
  Rat   397 RTMKGFMVLIEKDWISFGHKFSERCGHLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFNEAFLL 461

  Fly   494 ILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYKPNVDE--AIKANLA 556
            .:|:|:||||||.|:|||:|:|.:|:|.|:|:|||.::.....:|:||||......  .::.|.|
  Rat   462 QIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLADKKKYLNPLYSSKSQRLTVLEPNTA 526

  Fly   557 PQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNSLEDHVQHLTKRIASFKNYI--------- 612
            ....||||.||.:|:..:|||:.:.:::::..|....||:.|:.|..:|...|:.|
  Rat   527 SFNFKFWRNMYHQFDRTLHPRQSVLNIIMNMNEQNKQLEEDVKDLEAKIKQCKSGILTKDLLHAV 591

  Fly   613 ---SKSAKK---LQDATSAPGK-VNKELSSNEINDNKY-NYDKKLSELSAA 655
               |.|.|.   |::.:..|.| ..:.:..:...||:| :|.::.|:...|
  Rat   592 HPESPSLKTSLCLKEQSLLPVKDTLRAVEGSSPADNRYCDYTEEFSKSEPA 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtmr6	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	52/93 (56%)
		PTP-MTMR6-like	202..501	CDD:350380	187/338 (55%)
		FYVE_MTMR_unchar	693..753	CDD:277277
Mtmr6	NP_001381640.1	PH-GRAM_MTMR6	1..101	CDD:270151	52/93 (56%)
		Interaction with RAB1B. /evidence=ECO:0000250|UniProtKB:Q8VE11	2..141		65/133 (49%)
		PTP_DSP_cys	130..469	CDD:475123	207/378 (55%)